The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation.

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Abstract

This study characterized the kynurenine pathway (KP) in human obesity by evaluating circulating levels of kynurenines and the expression of KP enzymes in adipose tissue.

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Journal

Journal ID (iso-abbrev): Obesity (Silver Spring)

Title: Obesity (Silver Spring, Md.)

ISSN (Electronic): 1930-739X

ISSN (Print): 1930-7381

Publication date (Electronic): Oct 2015

Volume: 23

Issue: 10

Affiliations

[1 ] CNRS UMR 8199, Lille, France.

[2 ] University of Lille, Lille, France.

[3 ] Institut Pasteur De Lille, Lille, France.

[4 ] European Genomic Institute for Diabetes (EGID), Lille, France.

[5 ] CHRU De Lille, Lille, France.

[6 ] EA4483, Lille, France.

[7 ] INSERM UMR 1190, Lille, France.

[8 ] Qatar Biomedical Research Institute, Qatar Foundation, Doha, Qatar.

[9 ] INSERM U872, Paris, France.

[10 ] Immusmol, Pessac, France.

[11 ] Neuroinflammation Group, Macquarie University, Sydney, New South Wales, Australia.

[12 ] INSERM UMR 1011, Lille, France.

[13 ] INSERM UMRS 1018, Villejuif, France.

[14 ] Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK.

Article

DOI: 10.1002/oby.21199

PubMed ID: 26347385

SO-VID: b4cc23e8-f59b-4e25-a53d-1d7c1f60d745

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