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TP53 mutations and survival in squamous-cell carcinoma of the head and neck.
M Luana Poeta
1 ,
Judith Manola ,
Meredith A Goldwasser ,
Arlene Forastiere ,
Nicole Benoit ,
Joseph A Califano ,
John A Ridge ,
Jarrard Goodwin ,
Daniel Kenady ,
John Saunders ,
William Westra ,
David Sidransky ,
Wayne M Koch
Dec 20 2007
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Abstract
The abrogation of function of the tumor-suppressor protein p53 as a result of mutation of its gene, TP53, is one of the most common genetic alterations in cancer cells. We evaluated TP53 mutations and survival in patients with squamous-cell carcinoma of the head and neck.