Compensatory Hippocampal Recruitment Supports Preserved Episodic Memory in Autism Spectrum Disorder

Abstract

The degree to which individuals with autism spectrum disorder (ASD) evidence impairments in episodic memory relative to their typically developing (TD) counterparts remains unclear. According to a prominent view, ASD is associated with deficits in encoding associations between items and recollecting precise context details. Here, we evaluated behavioral and neural evidence for this impaired relational binding hypothesis using a task involving relational encoding and recollection during fMRI. Adolescents and young adults ( N ASD =47; N TD =60) performed the Relational and Item-Specific Encoding (RiSE) task during fMRI, including item and associative recognition testing. We modelled functional recruitment within the medial temporal lobes (MTL), and connectivity between MTL and the posterior medial (PM) network thought to underlie relational memory. The impaired relational binding model would predict a behavioral deficit driven by aberrant recruitment and connectivity of MTL and the PM network. The ASD and TD groups showed indistinguishable item and associative recognition performance. During relational encoding, the ASD group demonstrated increased hippocampal recruitment, and decreased connectivity between MTL and PM regions relative to TD. Within ASD, hippocampal recruitment and MTL-PM connectivity were inversely correlated. The lack of a behavioral deficit in ASD does not support the impaired relational binding hypothesis. Instead, the current data suggest that increased recruitment of the hippocampus compensates for decreased MTL-PM connectivity to support preserved episodic memory in ASD. These findings suggest a compensatory neurodevelopmental mechanism that may support preserved cognitive domains in ASD: local hyper-recruitment may offset connectivity aberrations in individuals with ASD relative to TD.