Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study.

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Abstract

Until now, polymyxin resistance has involved chromosomal mutations but has never been reported via horizontal gene transfer. During a routine surveillance project on antimicrobial resistance in commensal Escherichia coli from food animals in China, a major increase of colistin resistance was observed. When an E coli strain, SHP45, possessing colistin resistance that could be transferred to another strain, was isolated from a pig, we conducted further analysis of possible plasmid-mediated polymyxin resistance. Herein, we report the emergence of the first plasmid-mediated polymyxin resistance mechanism, MCR-1, in Enterobacteriaceae.

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Journal

Journal ID (iso-abbrev): Lancet Infect Dis

Title: The Lancet. Infectious diseases

Publisher: Elsevier BV

ISSN (Electronic): 1474-4457

ISSN (Print): 1473-3099

Publication date (Electronic): Feb 2016

Volume: 16

Issue: 2

Affiliations

[1 ] College of Veterinary Medicine, National Risk Assessment Laboratory for Antimicrobial Resistance of Microorganisms in Animals, South China Agricultural University, Guangzhou, China.

[2 ] Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China.

[3 ] Department of Medical Microbiology and Infectious Disease, Institute of Infection & Immunity, Heath Park Hospital, Cardiff, UK.

[4 ] The Second Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, China.

[5 ] School of Cellular and Molecular Medicine, University of Bristol, Biomedical Sciences Building, Bristol, UK.

[6 ] Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

[7 ] Sun Yat-sen University Zhongshan School of Medicine, Guangzhou, China.

[8 ] College of Veterinary Medicine, National Risk Assessment Laboratory for Antimicrobial Resistance of Microorganisms in Animals, South China Agricultural University, Guangzhou, China. Electronic address: jhliu@scau.edu.cn.

[9 ] Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China. Electronic address: sjz@cau.edu.cn.

Article

Publisher Item ID: S1473-3099(15)00424-7

DOI: 10.1016/S1473-3099(15)00424-7

PubMed ID: 26603172

SO-VID: b2a7ceab-d863-4091-b2bc-325c6db3c17b

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