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Abstract
The importance of sample size evaluation in clinical trials is reviewed and a general
method is presented from which specific equations are derived for sample size determination
or the analysis of power for a wide variety os statistical procedures. The method
is discussed and illustrated in relation to the t test, tests for proportions, tests
of survival time, and tests for correlations as they commonly occur in clinical trials.
Most of the specific equations reduce to a simple general form for which tables are
presented.