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      A bibliometric analysis of cardiomyocyte apoptosis from 2014 to 2023: A review

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          Abstract

          Cardiomyocyte apoptosis is an important factor in cardiac function decline observed in various cardiovascular diseases. To understand the progress in the field of cardiomyocyte apoptosis research, this paper uses bibliometrics to statistically analyze publications in this field. A total of 5939 articles were retrieved from the core Web of Science database, and then VOSviewer and Citespace were used to conduct a scientometric analysis of the authors, countries, institutions, references and keywords included in the articles to determine the cooperative relationships between researchers that study cardiomyocyte apoptosis. At present, the research hotspots in this field mainly include experimental research, molecular mechanisms, pathophysiology and cardiac regeneration of cardiomyocyte apoptosis-related diseases. NOD-like receptor thermal protein domain associated protein 3 inflammasome, circular RNA, and sepsis are the research frontiers in this field and are emerging as new areas of research focus. This work provides insight into research directions and the clinical application value for the continued advancement of cardiomyocyte apoptosis research.

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          Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

          Circulation, 135(10)
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            Mechanism and medical implications of mammalian autophagy

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              Ferroptosis as a target for protection against cardiomyopathy

              Significance Nonapoptotic cell death-induced tissue damage has been implicated in a variety of diseases, including neurodegenerative disorder, inflammation, and stroke. In this study, we demonstrate that ferroptosis, a newly defined iron-dependent cell death, mediates both chemotherapy- and ischemia/reperfusion-induced cardiomyopathy. RNA-sequencing analysis revealed up-regulation of heme oxygenase 1 by doxorubicin as a major mechanism of ferroptotic cardiomyopathy. As a result, heme oxygenase 1 degrades heme and releases free iron in cardiomyocytes, which in turn leads to generation of oxidized lipids in the mitochondria membrane. Most importantly, both iron chelation therapy and pharmacologically blocking ferroptosis could significantly alleviate cardiomyopathy in mice. These findings suggest targeting ferroptosis as a strategy for treating deadly heart disease.
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                Author and article information

                Contributors
                Journal
                Medicine (Baltimore)
                Medicine (Baltimore)
                MD
                Medicine
                Lippincott Williams & Wilkins (Hagerstown, MD )
                0025-7974
                1536-5964
                24 November 2023
                24 November 2023
                : 102
                : 47
                : e35958
                Affiliations
                [a ] Chengdu University of Traditional Chinese Medicine, Chengdu, China
                [b ] Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
                Author notes
                [* ]Correspondence: Wen Xie, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China (e-mail: 2489983684@ 123456qq.com ).
                Author information
                https://orcid.org/0009-0001-1914-0287
                Article
                00039
                10.1097/MD.0000000000035958
                10681623
                38013295
                b2406f77-142b-4d39-8970-52f6aff4191f
                Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

                This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 7 August 2023
                : 12 October 2023
                : 13 October 2023
                Categories
                3400
                Research Article
                Narrative Review
                Custom metadata
                TRUE

                bibliometric,cardiomyocyte apoptosis,citespace,visualization,vosviewer

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