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      Factors associated with SARS-CoV-2 infection in unvaccinated children and young adults

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          Abstract

          Background and objectives

          Pediatric COVID-19 cases are often mild or asymptomatic, which has complicated estimations of disease burden using existing testing practices. We aimed to determine the age-specific population seropositivity and risk factors of SARS-CoV-2 seropositivity among children and young adults during the pandemic in British Columbia (BC).

          Methods

          We conducted two cross-sectional serosurveys: phase 1 enrolled children and adults < 25 years between November 2020-May 2021 and phase 2 enrolled children < 10 years between June 2021-May 2022 in BC. Participants completed electronic surveys and self-collected finger-prick dried blood spot (DBS) samples. Samples were tested for immunoglobulin G antibodies against ancestral spike protein (S). Descriptive statistics from survey data were reported and two multivariable analyses were conducted to evaluate factors associated with seropositivity.

          Results

          A total of 2864 participants were enrolled, of which 95/2167 (4.4%) participants were S-seropositive in phase 1 across all ages, and 61/697 (8.8%) unvaccinated children aged under ten years were S-seropositive in phase 2. Overall, South Asian participants had a higher seropositivity than other ethnicities (13.5% vs. 5.2%). Of 156 seropositive participants in both phases, 120 had no prior positive SARS-CoV-2 test. Young infants and young adults had the highest reported seropositivity rates (7.0% and 7.2% respectively vs. 3.0-5.6% across other age groups).

          Conclusions

          SARS-CoV-2 seropositivity among unvaccinated children and young adults was low in May 2022, and South Asians were disproportionately infected. This work demonstrates the need for improved diagnostics and reporting strategies that account for age-specific differences in pandemic dynamics and acceptability of testing mechanisms.

          Supplementary Information

          The online version contains supplementary material available at 10.1186/s12879-023-08950-1.

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          Most cited references20

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          Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.

          Research electronic data capture (REDCap) is a novel workflow methodology and software solution designed for rapid development and deployment of electronic data capture tools to support clinical and translational research. We present: (1) a brief description of the REDCap metadata-driven software toolset; (2) detail concerning the capture and use of study-related metadata from scientific research teams; (3) measures of impact for REDCap; (4) details concerning a consortium network of domestic and international institutions collaborating on the project; and (5) strengths and limitations of the REDCap system. REDCap is currently supporting 286 translational research projects in a growing collaborative network including 27 active partner institutions.
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            Seroprevalence of SARS-CoV-2 antibodies in children: a prospective multicentre cohort study

            Background Studies based on molecular testing of oral/nasal swabs underestimate SARS-CoV-2 infection due to issues with test sensitivity, test timing and selection bias. The objective of this study was to report the presence of SARS-CoV-2 antibodies, consistent with previous infection. Design This multicentre observational cohort study, conducted between 16 April to 3 July 2020 at 5 UK sites, recruited children of healthcare workers, aged 2–15 years. Participants provided blood samples for SARS-CoV-2 antibody testing and data were gathered regarding unwell contacts and symptoms. Results 1007 participants were enrolled, and 992 were included in the final analysis. The median age of participants was 10·1 years. There were 68 (6.9%) participants with positive SARS-CoV-2 antibody tests indicative of previous SARS-CoV-2 infection. Of these, 34/68 (50%) reported no symptoms prior to testing. The presence of antibodies and the mean antibody titre was not influenced by age. Following multivariable analysis four independent variables were identified as significantly associated with SARS-CoV-2 seropositivity: known infected household contact OR=10.9 (95% CI 6.1 to 19.6); fatigue OR=16.8 (95% CI 5.5 to 51.9); gastrointestinal symptoms OR=6.6 (95% CI 3.0 to 13.8); and changes in sense of smell or taste OR=10.0 (95% CI 2.4 to 11.4). Discussion Children demonstrated similar antibody titres in response to SARS-CoV-2 irrespective of age. Fatigue, gastrointestinal symptoms and changes in sense of smell or taste were the symptoms most strongly associated with SARS-CoV-1 antibody positivity. Trial registration number https://www.clinicaltrials.gov (trial registration: NCT0434740) on the 15 April 2020.
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              Association of Children’s Mode of School Instruction with Child and Parent Experiences and Well-Being During the COVID-19 Pandemic — COVID Experiences Survey, United States, October 8–November 13, 2020

              In March 2020, efforts to slow transmission of SARS-CoV-2, the virus that causes COVID-19, resulted in widespread closures of school buildings, shifts to virtual educational models, modifications to school-based services, and disruptions in the educational experiences of school-aged children. Changes in modes of instruction have presented psychosocial stressors to children and parents that can increase risks to mental health and well-being and might exacerbate educational and health disparities ( 1 , 2 ). CDC examined differences in child and parent experiences and indicators of well-being according to children’s mode of school instruction (i.e., in-person only [in-person], virtual-only [virtual], or combined virtual and in-person [combined]) using data from the COVID Experiences nationwide survey. During October 8–November 13, 2020, parents or legal guardians (parents) of children aged 5–12 years were surveyed using the NORC at the University of Chicago AmeriSpeak panel,* a probability-based panel designed to be representative of the U.S. household population. Among 1,290 respondents with a child enrolled in public or private school, 45.7% reported that their child received virtual instruction, 30.9% in-person instruction, and 23.4% combined instruction. For 11 of 17 stress and well-being indicators concerning child mental health and physical activity and parental emotional distress, findings were worse for parents of children receiving virtual or combined instruction than were those for parents of children receiving in-person instruction. Children not receiving in-person instruction and their parents might experience increased risk for negative mental, emotional, or physical health outcomes and might need additional support to mitigate pandemic effects. Community-wide actions to reduce COVID-19 incidence and support mitigation strategies in schools are critically important to support students’ return to in-person learning. The COVID Experiences nationwide survey was administered online or via telephone during October 8–November 13, 2020 to parents of children aged 5–12 years (1,561) using NORC’s AmeriSpeak panel ( 3 ). † A sample of adults in the AmeriSpeak panel identified as potential respondents was selected using sampling strata based on age, race/ethnicity, education, and sex of the adult. Parents with multiple children were asked to report on their child aged 5–12 years with the most recent birthday. Analyses were limited to parents of children attending a public or private school during the 2020–21 school year. § On the basis of parent responses about the mode of school instruction, ¶ three unweighted categories were constructed: in-person (434), virtual (530), and combined (326). Parents who did not select one of the prespecified modes of instruction categories or did not report their child attended a public or private school (271) were excluded from analyses. The final sample included 1,290 parents of children, 1,169 (92.9%) of whom were enrolled in public school and 121 (7.1%) enrolled in private school. Parents reported on children’s experiences and well-being, including changes since the pandemic began in physical activity and time spent outside; physical, mental, and emotional health status before and during the pandemic; and measures of current anxiety and depression.** In addition, parents reported on their own well-being and experiences, including job stability, child care challenges, and emotional distress. Unweighted frequencies or weighted prevalence estimates and 95% confidence intervals of demographic characteristics, experiences, and well-being indicators by school instruction mode were calculated. Chi-square tests identified differences by demographic characteristics. Controlling for child’s age and parent’s race/ethnicity, sex, and household income, the study calculated adjusted prevalence ratios using predicted margins in logistic regression, comparing experiences and well-being indicators by mode of instruction. P-values <0.05 were considered statistically significant. The complex sample design was accounted for using SAS-callable SUDAAN (version 11.0; RTI International). This activity was reviewed by CDC and was conducted consistent with applicable federal law and CDC policy; the study was also reviewed and approved by the Institutional Review Board of NORC at the University of Chicago. †† Approximately one half of parents (45.7%) reported that their child received virtual instruction, 30.9% reported in-person instruction, and 23.4% reported combined instruction (Table 1). Parents of children enrolled in public school more commonly reported that their children received virtual instruction (47.6%) compared with parents of children enrolled in private school (20.3%). Virtual instruction was also more commonly reported by Hispanic parents (65.9%), non-Hispanic other/multiracial parents (64.0%), and non-Hispanic Black parents (54.9%) than by non-Hispanic White parents (31.9%). TABLE 1 Respondent, child and household characteristics, by mode of child’s school instruction* — COVID Experiences Survey, † United States, October 8–November 13, 2020 Characteristic Mode of child’s§ school instruction,¶ no., % (95% CI) p-value†† Overall In-person only Virtual only Combined** Total 1,290 100.0 434 30.9 (26.3–35.9) 530 45.7 (40.0–51.5) 326 23.4 (19.9–27.4) Child characteristic Sex §§ 0.23 Male 519 51.7 (47.1–56.3) 180 29.5 (23.9–35.7) 201 45.4 (39.2–51.8) 138 25.1 (20.2–30.7) Female 455 48.3 (43.7–52.9) 151 30.6 (24.0–38.1) 201 50.3 (41.1–59.4) 103 19.2 (15.1–24.0) Age group, yrs 0.03 5–8 550 41.5 (38.3–44.9) 206 35.4 (29.3–42.0) 214 45.2 (39.1–51.4) 130 19.4 (15.0–24.7) 9–12 739 58.5 (55.1–61.7) 228 27.8 (22.7–33.4) 315 45.9 (38.8–53.1) 196 26.4 (21.5–31.9) Existing emotional, mental, developmental, or behavioral condition ¶¶ 0.56 Yes 255 18.9 (16.0–22.1) 81 30.6 (23.3–39.1) 112 49.2 (38.8–59.7) 62 20.2 (14.8–27.0) No 1,032 81.1 (77.9–84.0) 352 31.0 (26.2–36.3) 417 45.0 (39.5–50.6) 263 24.0 (20.2–28.4) Child’s school type <0.01 Public 1,169 92.9 (91.3–94.3) 352 28.3 (23.6–33.4) 507 47.6 (41.6–53.7) 310 24.1 (20.5–28.2) Private 121 7.1 (5.7–8.7) 82 65.6 (54.5–75.2) 23 20.3 (13.0–30.2) 16 14.2 (9.0–21.5) Child receives free or reduced cost lunch*** 0.85 Yes 746 59.7 (56.7–62.7) 245 30.7 (26.3–35.4) 310 46.5 (40.1–53.0) 191 22.8 (18.3–28.0) No 541 40.3 (37.3–43.3) 189 31.4 (25.3–38.3) 218 44.6 (37.6–51.7) 134 24.0 (19.9–28.7) Parent and household characteristic Sex 0.81 Male 427 44.5 (40.8–48.3) 155 32.2 (26.2–38.9) 166 44.5 (37.3–52.0) 106 23.3 (17.6–30.1) Female 863 55.5 (51.7–59.2) 279 29.8 (24.4–35.9) 364 46.6 (40.1–53.2) 220 23.6 (20.4–27.0) Race/Ethnicity <0.01 White, non-Hispanic 870 55.8 (51.3–60.3) 352 39.5 (33.6–45.7) 271 31.9 (26.4–38.0) 247 28.6 (23.7–34.0) Black, non-Hispanic 132 9.4 (7.3–12.1) 31 30.7 (19.8–44.1) 80 54.9 (44.9–64.5) 21 14.5 (7.3–26.6) Hispanic 163 23.8 (19.2–29.0) 28 17.5 (9.6–29.5) 106 65.9 (55.2–75.2) 29 16.6 (10.5–25.3) Other, non-Hispanic††† 125 11.0 (8.9–13.5) 23 16.4 (9.9–25.9) 73 64.0 (48.3–77.2) 29 19.6 (11.0–32.5) Marital status 0.39 Married or living with partner 1,050 82.5 (79.7–85.0) 366 30.9 (26.1–36.3) 429 46.6 (40.3–53.0) 255 22.5 (18.7–26.8) Never married, divorced, widowed, or separated 240 17.5 (15.0–20.3) 68 30.6 (24.2–37.8) 101 41.5 (33.7–49.7) 71 27.9 (21.1–35.9) Parental education 0.29 Less than high school or high school graduate 203 31.2 (27.0–35.8) 71 33.6 (25.8–42.4) 82 45.9 (35.5–56.6) 50 20.5 (14.4–28.5) Some college or technical school or associate degree 493 26.3 (23.6–29.2) 166 31.8 (25.2–39.2) 201 43.1 (36.9–49.4) 126 25.2 (19.9–31.3) Bachelor’s degree or higher 594 42.5 (38.7–46.3) 197 28.3 (23.3–33.9) 247 47.2 (41.1–53.3) 150 24.5 (20.7–28.8) Annual household income 0.56 ≤$34,999 279 26.3 (22.9–30.0) 82 33.0 (25.2–41.9) 123 48.5 (38.4–58.6) 74 18.5 (13.4–25.1) $35,000–$49,999 157 13.6 (11.2–16.3) 51 27.2 (18.1–38.7) 64 50.1 (37.3–62.9) 42 22.7 (14.4–33.8) $50,000–$74,999 266 17.4 (15.2–19.9) 89 32.8 (26.5–39.8) 110 42.2 (32.9–52.0) 67 25.0 (18.4–33.1) $75,000–$99,999 228 14.6 (12.4–17.1) 87 31.4 (24.5–39.3) 90 42.5 (34.9–50.5) 51 26.1 (18.0–36.2) ≥$100,000 360 28.2 (24.7–31.8) 125 29.2 (22.7–36.7) 143 44.8 (37.0–52.8) 92 26.0 (20.9–31.9) Abbreviation: CI = confidence interval. * Table shows unweighted frequencies, weighted overall and row percentages, and weighted 95% CIs. † https://amerispeak.norc.org/Documents/Research/AmeriSpeak%20Technical%20Overview%202019%2002%2018.pdf § Sampled parents with multiple children were asked to report on their child aged 5–12 years with the most recent birthday. ¶ Among those who responded that their child attended a public or private school in the 2020–21 school year, mode of instruction categories are based on response to the question “During the current school year (2020/21), how has [the child] attended school? Select all that apply.” Possible responses were “in-person full time,” “virtual/online full-time,” “in-person part-time and virtual part-time (meaning in school several days a week or several weeks each month, and virtual learning the other days/weeks),” or “other, please specify.” Three mutually exclusive categories were based on the selection of: 1) only in-person full time; 2) only virtual/online full-time; or 3) combination of in-person full time, virtual/online full-time, or in-person part-time and virtual part-time. ** Indicates a combination of in-person and virtual instruction. †† Chi-square test was used to identify overall differences in child and parent demographics and household characteristics by mode of school instruction. §§ First name-based imputation was used to impute sex for 148 children who were missing information on sex. After imputation, child’s sex remained missing for 316 records (24.5%). ¶¶ Any emotional, mental, developmental, or behavioral condition for which the child needed or received treatment, therapy, or counseling. Examples include anxiety, depression, attention deficit disorder or attention deficit hyperactivity disorder, autism spectrum disorder, or intellectual disability. *** Question assessed whether child ever received free or reduced-cost school meals (i.e., breakfast, lunch, or both). ††† Includes other non-Hispanic races and non-Hispanic multiracial persons. Parents of children receiving virtual instruction were more likely than were parents of children receiving in-person instruction to report that their children experienced decreased physical activity (62.9% versus 30.3%), time spent outside (58.0% versus 27.4%), in-person time with friends (86.2% versus 69.5%), virtual time with friends (24.3% versus 12.6%), and worsened mental or emotional health (24.9% versus 15.9%) (Table 2). Parents of children receiving combined instruction were also more likely than were those of children receiving in-person instruction to report that their children experienced decreased physical activity (52.1% versus 30.3%), time spent outside (42.4% versus 27.4%), in-person time with friends (84.1% versus 69.5%), and worsened mental or emotional health (24.7% versus 15.9%). Parents of children receiving virtual instruction were more likely than were parents of children receiving combined instruction to report that their children experienced decreased physical activity (62.9% versus 52.1%) and time spent outside (58.0% versus 42.4%). TABLE 2 Weighted prevalence (%) and adjusted prevalence ratios (aPRs) of parent report of child experiences and well-being indicators, by mode of child’s school instruction* — COVID Experiences Survey, † United States, October 8–November 13, 2020 Characteristic Mode of child’s§ school instruction,¶ % (95% CI) Adjusted comparisons for child experiences and well-being by mode of child’s school instruction, aPR** (95% CI) Overall (N = 1,290) In-person only (n = 434) Virtual only (n = 530) Combined†† (n = 326) Virtual only versus in-person only Combined versus in-person only Virtual only versus combined Child experience Change in physical activity §§ Decreased 50.3 (46.5–54.0) 30.3 (25.1–36.1) 62.9 (58.1–67.4) 52.1 (45.8–58.3) 1.9 (1.6–2.3)¶¶ 1.6 (1.3–1.9)¶¶ 1.2 (1.0–1.4)¶¶ No impact or increased 49.7 (46.0–53.5) 69.7 (63.9–74.9) 37.1 (32.6–41.9) 47.9 (41.7–54.2) — — — Change in spending time outside §§ Decreased 44.9 (40.9–48.9) 27.4 (21.9–33.8) 58.0 (52.2–63.5) 42.4 (36.1–49.0) 1.8 (1.4–2.2)¶¶ 1.4 (1.1–1.8)¶¶ 1.3 (1.1–1.6)¶¶ No impact or increased 55.1 (51.1–59.1) 72.6 (66.2–78.1) 42.0 (36.5–47.8) 57.6 (51.0–63.9) — — — Change in spending time with friends in-person §§ Decreased 80.5 (76.9–83.7) 69.5 (62.7–75.5) 86.2 (81.4–89.9) 84.1 (76.3–89.6) 1.2 (1.1–1.3)¶¶ 1.2 (1.1–1.3)¶¶ 1.1 (0.9–1.2) No impact or increased 19.5 (16.3–23.1) 30.5 (24.5–37.3) 13.8 (10.1–18.6) 15.9 (10.4–23.7) — — — Change in spending time with friends virtually for non-educational purposes §§ Decreased 18.6 (15.6–22.0) 12.6 (8.6–18.2) 24.3 (19.1–30.4) 15.3 (10.6–21.5) 1.7 (1.1–2.7)¶¶ 1.2 (0.8–2.0) 1.4 (0.9–2.1) No impact or increased 81.4 (78.0–84.4) 87.4 (81.8–91.4) 75.7 (69.6–80.9) 84.7 (78.5–89.4) — — — Child well-being Change in physical health*** Worse 12.6 (10.2–15.6) 9.3 (6.2–13.6) 14.7 (10.3–20.5) 13.0 (9.4–17.8) 1.4 (0.8–2.3) 1.3 (0.8–2.2) 1.1 (0.7–1.7) Better or no change 87.4 (84.4–89.8) 90.7 (86.4–93.8) 85.3 (79.5–89.7) 87.0 (82.2–90.6) — — — Change in mental or emotional health ††† Worse 22.1 (19.8–24.7) 15.9 (12.5–20.1) 24.9 (21.4–28.8) 24.7 (20.4–29.5) 1.6 (1.2–2.2)¶¶ 1.5 (1.1–2.0)¶¶ 1.1 (0.9–1.4) Better or no change 77.9 (75.3–80.2) 84.1 (79.9–87.5) 75.1 (71.2–78.6) 75.3 (70.5–79.6) — — — Depression §§§ With elevated symptoms 4.4 (2.8–6.9) 3.6 (1.9–6.9) 5.3 (2.7–10.3) 3.7 (1.8–7.3) 1.4 (0.6–3.1) 1.0 (0.4–2.5) 1.4 (0.6–3.3) Without elevated symptoms 95.6 (93.1–97.2) 96.4 (93.1–98.1) 94.7 (89.7–97.3) 96.3 (92.7–98.2) — — — Anxiety §§§ With elevated symptoms 6.3 (5.0–7.8) 6.7 (4.4–10.1) 7.0 (5.1–9.5) 4.4 (2.5–7.6) 1.1 (0.6–2.0) 0.7 (0.3–1.4) 1.6 (0.8–3.2) Without elevated symptoms 93.7 (92.2–95.0) 93.3 (89.9–95.6) 93.0 (90.5–94.9) 95.6 (92.4–97.5) — — — Psychological stress §§§ With elevated symptoms 9.2 (7.3–11.5) 9.5 (6.7–13.4) 9.2 (6.2–13.3) 8.7 (6.2–12.0) 1.0 (0.6–1.7) 0.9 (0.6–1.4) 1.2 (0.7–1.9) Without elevated symptoms 90.8 (88.5–92.7) 90.5 (86.6–93.3) 90.8 (86.7–93.8) 91.3 (88.0–93.8) — — — Abbreviation: CI = confidence interval. * Table shows weighted overall and column percentages and corresponding 95% CIs, and adjusted prevalence ratios and 95% CIs. † https://amerispeak.norc.org/Documents/Research/AmeriSpeak%20Technical%20Overview%202019%2002%2018.pdf § Sampled parents with multiple children were asked to report on their child aged 5–12 years with the most recent birthday. ¶ Among those who responded that their child attended a public or private school in the 2020–21 school year, mode of instruction categories are based on response to the question “During the current school year (2020/21), how has [the child] attended school? Select all that apply.” Possible responses were “in-person full time,” “virtual/online full-time,” “in-person part-time and virtual part-time (meaning in school several days a week or several weeks each month, and virtual learning the other days/weeks),” or “other, please specify.” Three mutually exclusive categories were based on the selection of: 1) only in-person full time; 2) only virtual/online full-time; or 3) combination of in-person full time, virtual/online full-time, or in-person part-time and virtual part-time. ** aPR adjusted for parent’s race/ethnicity and sex, household income, and child’s age. aPR was not adjusted for all child characteristics (sex; existing emotional, mental, developmental, or behavioral condition; school type; receipt of free or reduced-cost lunch) and parent characteristics (marital status or education). †† Indicates a combination of in-person and virtual instruction. §§ Question assessed how the COVID-19 pandemic has affected each behavior or experience. ¶¶ p-values <0.05 were considered statistically significant. Some 95% CIs include 1.0 because of rounding. *** Question items asked parents to rate child’s physical health (very good, good, fair, or poor) before the COVID-19 pandemic (February 2020) and current physical health. Any decline in physical health was categorized as “worse” and any improvement or no change in physical health was categorized as “better or no change.” ††† Question items asked parents to rate the child’s mental and emotional health (very good, good, fair, or poor) before the COVID-19 pandemic (February 2020) and current mental or emotional health. Any decline in mental or emotional health was categorized as “worse” and any improvement or no change in mental or emotional health was categorized as “better or no change.” §§§ Patient Reported Outcomes Measurement Information System (http://www.healthmeasures.net/) parent proxy report scales short forms, depressive symptoms, anxiety symptoms, and psychological stress. Raw scores are converted to T-scores, with a mean of 50 and standard deviation (SD) of 10 referenced to a healthy cohort. High scores indicate more of the concept measured. Elevated symptoms of depression (moderately severe/severe), anxiety (moderately severe/severe), and psychological stress (moderately high/very high) include those with T-scores≥65, 1.5 SDs higher than the mean of the reference population. Automated scoring was provided through Northwestern University, HealthMeasures. https://www.assessmentcenter.net/ac_scoringservice Parents of children receiving virtual instruction were also more likely than were parents of children receiving in-person instruction to report loss of work §§ (42.7% versus 30.6%), job stability concerns (26.6% versus 15.2%), child care challenges (13.5% versus 6.8%), conflict between working and providing child care (14.6% versus 8.3%), emotional distress (54.0% versus 38.4%), and difficulty sleeping (21.6% versus 12.9%) (Table 3). Parents of children receiving combined instruction were more likely than were those of children receiving in-person instruction to report loss of work (40.1% versus 30.6%) and conflict between working and providing child care (14.2% versus 8.3%). Parents of children receiving virtual instruction were more likely than were parents of children receiving combined instruction to report experiencing emotional distress (54.0% versus 42.9%). TABLE 3 Weighted prevalence (%) and adjusted prevalence ratios (aPRs) of parent experiences and well-being indicators, by mode of child’s school instruction* — COVID Experiences Survey, † United States, October 8–November 13, 2020 Characteristic Mode of child’s school instruction,§ % (95% CI) Adjusted comparisons for parent experiences and well-being by mode of child’s school instruction, aPR¶ (95% CI) Overall (N = 1,290) In-person only (n = 434) Virtual only (n = 530) Combined** (n = 326) Virtual only versus in-person only Combined** versus in-person only Virtual only versus combined** Parent experience Loss of work†† Yes 38.3 (34.5–42.3) 30.6 (25.4–36.3) 42.7 (36.5–49.1) 40.1 (31.9–48.8) 1.4 (1.1–1.8)§§ 1.4 (1.0–1.8)§§ 1.0 (0.8–1.3) No 61.7 (57.7–65.5) 69.4 (63.7–74.6) 57.3 (50.9–63.5) 59.9 (51.2–68.1) — — — Concern about job stability ¶¶ Often 21.5 (18.2–25.1) 15.2 (12.0–19.2) 26.6 (21.5–32.4) 19.6 (14.1–26.5) 1.6 (1.3–2.1)§§ 1.3 (0.9–1.9) 1.2 (0.8–1.8) Sometimes or never 78.5 (74.9–81.8) 84.8 (80.8–88.0) 73.4 (67.6–78.5) 80.4 (73.5–85.9) — — — Child care challenges ¶¶ Often 10.5 (8.6–12.7) 6.8 (4.5–10.3) 13.5 (10.3–17.4) 9.5 (6.5–13.7) 1.7 (1.1–2.7)§§ 1.4 (0.9–2.2) 1.2 (0.7–2.0) Sometimes or never 89.5 (87.3–91.4) 93.2 (89.7–95.5) 86.5 (82.6–89.7) 90.5 (86.3–93.5) — — — Conflict between working and providing child care ¶¶ Often 12.6 (10.5–14.9) 8.3 (5.9–11.5) 14.6 (11.7–18.1) 14.2 (10.0–19.7) 1.5 (1.0–2.3)§§ 1.7 (1.1–2.5)§§ 0.9 (0.6–1.5) Sometimes or never 87.4 (85.1–89.5) 91.7 (88.5–94.1) 85.4 (81.9–88.3) 85.8 (80.3–90.0) — — — Increased substance use*** Yes 16.5 (13.8–19.6) 13.7 (10.5–17.8) 16.4 (12.0–21.9) 20.5 (15.1–27.1) 1.2 (0.8–1.7) 1.5 (1.0–2.3) 0.8 (0.5–1.1) No 83.5 (80.4–86.2) 86.3 (82.2–89.5) 83.6 (78.1–88.0) 79.5 (72.9–84.9) — — — Parent well-being Emotional Distress ††† A lot or moderate 46.6 (43.3–49.9) 38.4 (32.7–44.5) 54.0 (48.8–59.1) 42.9 (35.9–50.1) 1.4 (1.2–1.6)§§ 1.1 (0.9–1.4) 1.2 (1.1–1.5)§§ Little or no 53.4 (50.1–56.7) 61.6 (55.5–67.3) 46.0 (40.9–51.2) 57.1 (49.9–64.1) — — — Difficulty managing emotions ¶¶ Often 13.5 (11.1–16.3) 11.0 (7.8–15.2) 14.3 (11.0–18.5) 15.2 (10.5–21.5) 1.1 (0.7–1.7) 1.4 (0.9–2.0) 0.8 (0.5–1.2) Sometimes or never 86.5 (83.7–88.9) 89.0 (84.8–92.2) 85.7 (81.5–89.0) 84.8 (78.5–89.5) — — — Difficulty sleeping or insomnia ¶¶ Often 17.7 (15.3–20.5) 12.9 (9.8–16.8) 21.6 (17.8–26.1) 16.4 (11.8–22.5) 1.6 (1.2–2.2)§§ 1.2 (0.9–1.7) 1.3 (0.9–1.8) Sometimes or never 82.3 (79.5–84.7) 87.1 (83.2–90.2) 78.4 (73.9–82.2) 83.6 (77.5–88.2) — — — Abbreviation: CI = confidence interval. * Table shows weighted overall and column percentages and corresponding 95% CIs, and adjusted prevalence ratios and 95% confidence intervals. † https://amerispeak.norc.org/Documents/Research/AmeriSpeak%20Technical%20Overview%202019%2002%2018.pdf § Among those who responded that their child attended a public or private school in the 2020–21 school year, mode of instruction categories are based on response to the question “During the current school year (2020/21), how has [the child] attended school? Select all that apply.” Possible responses were “in-person full time,” “virtual/online full-time,” “in-person part-time and virtual part-time (meaning in school several days a week and virtual learning the other days/weeks),” or “other, please specify.” Three mutually exclusive categories were based on the selection of: 1) only in-person full time; 2) only virtual/online full-time; or 3) combination of in-person full time, virtual/online full-time, or in-person part-time and virtual part-time. ¶ aPR adjusted for parent’s race/ethnicity and sex, household income, and child’s age. aPR was not adjusted for all child characteristics (sex; existing emotional, mental, developmental, or behavioral condition; school type; receipt of free or reduced-cost lunch) and parent characteristics (marital status or education). ** Indicates a combination of in-person and virtual instruction. †† Question assessed whether the respondent experienced or was experiencing any of the following as a result of the pandemic: loss of work, decreased hours or wages, furloughed, or laid off. §§ p-values <0.05 were considered statistically significant. Some 95% CIs include 1.0 because of rounding. ¶¶ Question assessed how frequently the respondent experienced the following since the COVID-19 pandemic began: concern about job stability, child care challenges, conflict between working and providing child care, difficulty managing emotions, difficulty sleeping, or insomnia. *** Question assessed whether the respondent started or increased using substances to help cope with stress or emotions during the COVID-19 pandemic. Substance use includes alcohol, legal or illegal drugs, or prescription drugs that are taken in a way not recommended by a doctor. ††† Question assessed how much emotional distress such as increased sadness, anxiety, and worry the respondent experienced related to the COVID-19 pandemic. Discussion Findings from this survey of parents of children aged 5–12 years indicate that parents whose children received virtual or combined instruction were more likely to report higher prevalence of risk on 11 of 17 indicators of child and parental well-being than were parents whose children received in-person instruction. Among nine examined indicators of children’s well-being, five differed significantly by the instruction mode that children received. These differences reflected higher prevalences of negative indicators of well-being for children receiving virtual or combined instruction than for children receiving in-person instruction. Parents of children receiving virtual or combined instruction more frequently reported that their child’s mental or emotional health worsened during the pandemic and that their time spent outside, in-person with friends, and engaged in physical activity decreased. Regular physical activity is associated with children’s improved cardiorespiratory fitness, increased muscle and bone strength, and reduced risk for depression, anxiety, and chronic health conditions (e.g., diabetes); therefore, these differences in physical activity are concerning ( 4 , 5 ). Likewise, isolation and limited physical and outside activity can adversely affect children’s mental health ( 6 ). Among the eight examined indicators of parental well-being, six differed significantly by mode of instruction received by the children. Parents of children receiving virtual instruction more frequently reported their own emotional distress, difficulty sleeping, loss of work, concern about job stability, child care challenges, and conflict between working and providing child care than did parents whose children were receiving in-person instruction. Parents of children receiving combined instruction also reported conflict between working and providing child care and loss of work more often than did parents of children receiving in-person instruction. Chronic stress can negatively affect physical and mental health of both children and parents, especially without social and economic supports, and could contribute to widening of educational and health disparities ( 2 , 3 , 7 , 8 ). In this study, Black, Hispanic, and non-Hispanic other or multiracial parents were more likely than White parents to report children receiving virtual instruction. Further research is needed to understand whether virtual instruction has disproportionately negative impacts on child and parent health outcomes among racial and ethnic minorities and communities disproportionately affected by COVID-19. The role of other contextual and interpersonal factors on experiences of stress and risks to well-being in relation to the pandemic needs further exploration. Schools are central to supporting children and families, providing not only education, but also opportunities to engage in activities to support healthy development and access to social, mental health, and physical health services, which can buffer stress and mitigate negative outcomes. However, the pandemic is disrupting many school-based services, increasing parental responsibilities and stress, and potentially affecting long-term health outcomes for parents and children alike, especially among families at risk for negative health outcomes from social and environmental factors ( 2 , 7 , 9 , 10 ). These findings suggest that virtual instruction might present more risks than does in-person instruction related to child and parental mental and emotional health and some health-supporting behaviors, such as engaging in physical activity, with combined instruction falling between. The findings in this report are subject to at least six limitations. First, responses from this incentivized, English-language survey might not represent the broader U.S. population, and the limited sample size and response rate might affect generalizability. Second, although survey responses were weighted to approximate representativeness of U.S. household demographics, findings might not be representative of all U.S. students and children aged 5–12 years. Third, parent self-reports and proxy reports for children are subject to social desirability, proxy-response, and recall biases. Fourth, parents of children receiving combined instruction did not provide details on how often children received in-person or virtual instruction; additional variation within this category might exist. Fifth, the study did not adjust for all potential confounders such as community COVID-19 transmission levels and some household and individual characteristics (e.g., urbanicity or rurality, or number of children in the household). Finally, causality between instruction mode and examined indicators of well-being cannot be inferred from this cross-sectional study. Parents of children receiving in-person instruction reported the lowest prevalence of negative indicators of child and parental well-being. Children receiving virtual or combined instruction and their parents might need additional support to mitigate stress, including linkage to social and mental health services and opportunities to engage in safe physical activity to reduce risks associated with chronic health conditions. Culturally applicable support programming and resources might be warranted to meet community needs, ensure equitable access to services, and address health or educational inequities for families from racial and ethnic minority groups. These findings highlight the importance of in-person learning for children’s physical and mental well-being and for parents’ emotional well-being. Community-wide actions ¶¶ to reduce COVID-19 incidence and support mitigation strategies in schools*** are critically important to support students’ return to in-person learning. Summary What is already known about the topic? COVID-19–associated schooling changes present stressors to children and parents that might increase risks to mental health and well-being. What is added by this report? In a probability-based survey of parents of children aged 5–12 years, 45.7% reported that their children received virtual instruction only, 30.9% in-person only, and 23.4% combined virtual and in-person instruction. Findings suggest that virtual instruction might present more risks than does in-person instruction related to child and parental mental and emotional health and some health-supporting behaviors. What are the implications for public health practice? Children not receiving full-time, in-person instruction and their parents might need additional supports to mitigate pandemic impacts.
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                Author and article information

                Contributors
                msadarangani@bcchr.ubc.ca
                Journal
                BMC Infect Dis
                BMC Infect Dis
                BMC Infectious Diseases
                BioMed Central (London )
                1471-2334
                15 January 2024
                15 January 2024
                2024
                : 24
                : 91
                Affiliations
                [1 ]Vaccine Evaluation Center, BC Children’s Hospital Research Institute, ( https://ror.org/00gmyvv50) 950 West 28th Ave Vancouver, V5Z 4H4 Vancouver, BC Canada
                [2 ]Division of Infectious Diseases, Department of Pediatrics, University of Toronto, ( https://ror.org/03dbr7087) Toronto, ON Canada
                [3 ]Department of Pediatrics, University of British Columbia, ( https://ror.org/03rmrcq20) Vancouver, BC Canada
                [4 ]Experimental Medicine Program, Department of Medicine, University of British Columbia, ( https://ror.org/03rmrcq20) Vancouver, BC Canada
                [5 ]Public Health Laboratory, BC Centre for Disease Control, ( https://ror.org/05jyzx602) Vancouver, BC Canada
                [6 ]Department of Mathematics, University of British Columbia, ( https://ror.org/03rmrcq20) Vancouver, BC Canada
                [7 ]GRID grid.411418.9, ISNI 0000 0001 2173 6322, Centre de Recherche du CHU Sainte-Justine, ; Montreal, QC Canada
                [8 ]Department of Pathology and Laboratory Medicine, University of British Columbia, ( https://ror.org/03rmrcq20) Vancouver, BC Canada
                Article
                8950
                10.1186/s12879-023-08950-1
                10790408
                38225625
                b117aaa8-8bf1-4918-a76f-fadf444cfe80
                © The Author(s) 2024

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                History
                : 8 October 2023
                : 24 December 2023
                Funding
                Funded by: Canadian Immunization Research Network
                Funded by: Michael Smith Health Research BC
                Award ID: COV-2020-1033
                Funded by: Public Health Agency of Canada
                Award ID: 2021-HQ-000079
                Funded by: BC Children’s Hospital Foundation
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                Research
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                © BioMed Central Ltd., part of Springer Nature 2024

                Infectious disease & Microbiology
                sars-cov-2,infection,pediatric
                Infectious disease & Microbiology
                sars-cov-2, infection, pediatric

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