For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
14
views
29
references
 Top references
cited by
12
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      343
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Upregulation of lncRNA ZFAS1 promotes lung adenocarcinoma progression by sponging miR‐1271‐5p and upregulating FRS2

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          Nowadays, the important roles of long non‐coding RNAs (LncRNAs) in lung adenocarcinoma (LAD) is being increasingly recognized. The purpose of this study was to explore the regulatory mechanism of lncRNA ZFAS1 in LAD.

          Methods

          The expression and function of lncRNA ZFAS1 were assessed by RT‐qPCR, CCK‐8, transwell and dual luciferase reporter assays.

          Results

          Upregulation of lncRNA ZFAS1 was found in LAD tissues and cells. Knockdown of lncRNA ZFAS1 restrained cell proliferation, migration and invasion in LAD cells. In addition, we determined that lncRNA ZFAS1 could directly bind to miR‐1271‐5p. MiR‐1271‐5p functioned as a tumor suppressor in LAD, and lncRNA ZFAS1 promoted LAD development by downregulating miR‐1271‐5p. Furthermore, FRS2 was a direct target of miR‐1271‐5p. FRS2 promoted progression of LAD by mediating lncRNA ZFAS1/miR‐1271‐5p axis.

          Conclusions

          LncRNA ZFAS1 promotes cell proliferation, migration and invasion in LAD by downregulating miR‐1271‐5p or upregulating FRS2.

          Related collections

          Most cited references29

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Long non-coding RNA: a new player in cancer

          Hua Zhang, Zhenhua Chen, Xinxin Wang … (2013)
          Emerging evidence showed that long non-coding RNAs (lncRNAs) play important roles in a wide range of biological processes and dysregulated lncRNAs are involved in many complex human diseases, including cancer. Although a few lncRNAs’ functions in cancer have been characterized, the detailed regulatory mechanisms of majority of lncRNAs in cancer initiation and progression remain largely unknown. In this review, we summarized recent progress on the mechanisms and functions of lncRNAs in cancer, especially focusing on the oncogenic and tumor suppressive roles of the newly identified lncRNAs, and the pathways these novel molecules might be involved in. Their potentials as biomarkers for diagnosis and prognosis in cancer are also discussed in this paper.
          Article 0 comments Cited 224 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found
            Is Open Access

            Exosomal lncRNA ZFAS1 regulates esophageal squamous cell carcinoma cell proliferation, invasion, migration and apoptosis via microRNA-124/STAT3 axis

            Zhirong Li, Xuebo Qin, Wei Bian … (2019)
            Background In recent years, long non-coding RNAs (lncRNAs) are of great importance in development of different types of tumors, while the function of lncRNA ZFAS1 is rarely discussed in esophageal squamous cell carcinoma (ESCC). Therefore, we performed this study to explore the expression of exosomal lncRNA ZFAS1 and its molecular mechanism on ESCC progression. Methods Expression of ZFAS1 and miR-124 in ESCC tissues was detected. LncRNA ZFAS1 was silenced to detect its function in the biological functions of ESCC cells. A stable donor and recipient culture model was established. Eca109 cells transfected with overexpressed and low expressed ZFAS1 plasmid and miR-124 inhibitor labeled by Cy3 were the donor cells, and then co-cultured with recipient cells to observe the transmission of Cy3-ZFAS1 between donor cells and recipient cells. The changes of cell proliferation, apoptosis, invasion, and migration in recipient cells were detected. The in vivo experiment was conducted for verifying the in vitro results. Results LncRNA ZFAS1 was upregulated and miR-124 was down-regulated in ESCC tissues. Silencing of ZFAS1 contributed to suppressed proliferation, migration, invasion and tumor growth in vitro and induced apoptosis of ESCC cells. LncRNA ZFAS1 was considered to be a competing endogenous RNA to regulate miR-124, thereby elevating STAT3 expression. Exosomes shuttled ZFAS1 stimulated proliferation, migration and invasion of ESCC cells and restricted their apoptosis with increased STAT3 and declined miR-124. Furthermore, in vivo experiment suggested that elevated ZFAS1-exo promoted tumor growth in nude mice. Conclusion This study highlights that exosomal ZFAS1 promotes the proliferation, migration and invasion of ESCC cells and inhibits their apoptosis by upregulating STAT3 and downregulating miR-124, thereby resulting in the development of tumorigenesis of ESCC.
            Article 0 comments Cited 96 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development

              Michael J Herriges, Daniel T. Swarr, Michael P. Morley … (2014)
              Long noncoding RNAs (lncRNAs) are thought to play important roles in regulating gene transcription, yet few have known biological functions. Using a conservative pipeline, Herriges et al. identify lncRNAs with key functions during mammalian development. Loss-of-function analyses show that two lncRNAs play distinct roles in endoderm development by controlling the expression of critical transcription factors and pathways, including retinoic acid signaling. The data demonstrate that lncRNAs regulate multiple aspects of gene transcription during foregut and lung endoderm development.
              Article 0 comments Cited 66 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Fulu Chu:
                ORCID: https://orcid.org/0000-0003-4324-3523
                cus62e@163.com
                Journal
                Journal ID (nlm-ta): Thorac Cancer
                Journal ID (iso-abbrev): Thorac Cancer
                Journal ID (doi): 10.1111/(ISSN)1759-7714
                Journal ID (publisher-id): TCA
                Title: Thoracic Cancer
                Publisher: John Wiley & Sons Australia, Ltd (Melbourne )
                ISSN (Print): 1759-7706
                ISSN (Electronic): 1759-7714
                Publication date (Electronic): 08 June 2020
                Publication date (Print): August 2020
                Volume: 11
                Issue: 8 ( doiID: 10.1111/tca.v11.8 )
                Pages: 2178-2187
                Affiliations
                [ 1 ] Department of Clinical Laboratory Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan China
                [ 2 ] Department of Clinical Laboratory Shandong Maternal and Child Health Care Hospital Jinan China
                Author notes
                [*] [* ] Correspondence

                Fulu Chu, Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwuweiqi Road, Huaiying District, Jinan, Shandong Province, 250021, China.

                Tel: +86 0531‐87938911

                Fax: +86 0531‐87938911

                Email: cus62e@ 123456163.com

                Author information
                https://orcid.org/0000-0003-4324-3523
                Article
                Publisher ID: TCA13525
                DOI: 10.1111/1759-7714.13525
                PMC ID: 7396366
                PubMed ID: 32515146
                SO-VID: af187d2c-db43-44b9-8f0f-a513b01609fe
                Copyright © © 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd
                License:

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 26 April 2020
                Date revision received : 10 May 2020
                Date accepted : 14 May 2020
                Page count
                Figures: 5, Tables: 1, Pages: 10, Words: 4725
                Categories
                Subject: Original Article
                Subject: Original Articles
                Custom metadata
                source-schema-version-number 2.0
                cover-date August 2020
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.6 mode:remove_FC converted:02.08.2020

                Keywords: frs2,lncrna zfas1,lung adenocarcinoma,mir‐1271‐5p
                Data availability:
                Keywords: frs2, lncrna zfas1, lung adenocarcinoma, mir‐1271‐5p

                Comments

                Comment on this article

                scite_

                Similar content343

                See all similar

                Cited by12

                See all cited by

                Most referenced authors457

                See all reference authors