For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
26
views
28
references
 Top references
cited by
26
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      890
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Risk Factors and Biomarkers of Ischemic Stroke in Cancer Patients

      research-article
      Author(s): ,
      Publication date (Electronic):
      Journal: Journal of Stroke
      Publisher: Korean Stroke Society
      Keywords: Biomarker, Cancer, Ischemic stroke, Risk factor

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background and Purpose

          Stroke is common among cancer patients. However, risk factors and biomarkers of stroke in cancer patients are not well established. This study aimed to investigate risk factors and biomarkers as well as etiology of ischemic stroke in cancer patients.

          Methods

          A retrospective review was conducted in cancer patients with ischemic stroke who were admitted to a general hospital in Busan, Korea, between January 2003 and December 2012. The risk factors and biomarkers for stroke and stroke subtypes in cancer patients were compared with age- and sex-matched noncancer patients with ischemic stroke who were admitted to the same hospital during the same period.

          Results

          One hundred fifty-six cancer patients with ischemic stroke were identified. Cancer patients with ischemic stroke were found to have a significantly lower proportion of hypertension, atrial fibrillation, hyperlipidemia, and ischemic heart disease than noncancer patients with ischemic stroke. However, stroke biomarkers, such as erythrocyte sedimentation rate and high-sensitivity C-reactive protein, fibrinogen, pro-brain natriuretic peptide, and D-dimer levels, were significantly increased in cancer patients with ischemic stroke than in noncancer patients. Large-artery atherosclerosis and stroke of undetermined cause were more common in cancer patients with ischemic stroke than in noncancer patients with ischemic stroke.

          Conclusions

          Cancer patients with ischemic stroke showed different risk factors, stroke biomarkers, and stroke etiology compared with noncancer patients with ischemic stroke.

          Related collections

          Most cited references28

          • Record: found
          • Abstract: found
          • Article: not found

          Direct proinflammatory effect of C-reactive protein on human endothelial cells.

          V Pasceri, J T Willerson, E Yeh (2000)
          The acute-phase reactant C-reactive protein (CRP) is an important risk factor for coronary heart disease. However, the possible effects of CRP on vascular cells are not known. We tested the effects of CRP on expression of adhesion molecules in both human umbilical vein and coronary artery endothelial cells. Expression of vascular cell adhesion molecule (VCAM-1), intercellular adhesion molecule (ICAM-1), and E-selectin was assessed by flow cytometry. Incubation with recombinant human CRP (10 microg/mL) for 24 hours induced an approximately 10-fold increase in expression of ICAM-1 and a significant expression of VCAM-1, whereas a 6-hour incubation induced significant E-selectin expression. Adhesion molecule induction was similar to that observed in endothelial cells activated with interleukin-1beta. In coronary artery endothelial cells, induction of ICAM-1 and VCAM-1 was already present at 5 microg/mL and reached a maximum at 50 microg/mL, at which point a substantial increase in expression of E-selectin was also evident. The CRP effect was dependent on presence of human serum in the culture medium, because no effect was seen in cells cultured with serum-free medium. In contrast, interleukin-1beta was able to induce adhesion molecule expression in the absence of human serum. CRP induces adhesion molecule expression in human endothelial cells in the presence of serum. These findings support the hypothesis that CRP may play a direct role in promoting the inflammatory component of atherosclerosis and present a potential target for the treatment of atherosclerosis.
          Article 0 comments Cited 258 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Stroke and cancer: the importance of cancer-associated hypercoagulation as a possible stroke etiology.

            Christopher Schwarzbach, Anke Schaefer, Anne D. Ebert … (2012)
            The importance of cancer-associated hypercoagulability as a possible stroke etiology in patients with cancer has received relatively little attention to date. A recent study has suggested that cancer-associated hypercoagulation may be of special importance in the absence of conventional stroke mechanisms.
            Article 0 comments Cited 95 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Stroke in patients with cancer: incidence and etiology.

              Donald L DeAngelis, Z Segal, Stevan M Weine … (2004)
              To assess the incidence and type of strokes in patients with cancer at Memorial Sloan-Kettering Cancer Center. Retrospective review of all ischemic strokes diagnosed by a neurologist and confirmed by neuroimaging between February 1997 and April 2001 was conducted. Age, gender, cancer diagnosis and stage, and vascular risk factors were recorded. NIH Stroke Scale and modified Rankin Scale scores were calculated retrospectively. Stroke etiology was assigned independently by two neurologists using the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. Ninety-six patients with a confirmed stroke were identified. The median age was 67, and 61.5% were men. The distribution of vascular risk factors was comparable with that seen in large stroke trials. Lung cancer (30%) was the most common primary tumor followed by brain and prostate cancer (9% each). Strokes were embolic in 52 (54%) and nonembolic in 44 (46%). Eleven of 12 tested patients had an elevated D-dimer level, but in only 3 patients could a definitive diagnosis of nonbacterial thrombotic endocarditis be made. The median survival was 4.5 months (95% CI 2.8 to 9.5) from the diagnosis of stroke; 25% of patients died within 30 days. Treatment had no effect on survival. Embolic strokes are the commonest cause of stroke in patients with cancer, due partially to hypercoagulability, whereas atherosclerosis accounted for only 22% of stroke in this population. Outcome was primarily determined by the underlying malignancy and the patient's neurologic condition.
              Article 0 comments Cited 88 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): J Stroke
                Journal ID (iso-abbrev): J Stroke
                Journal ID (publisher-id): JOS
                Title: Journal of Stroke
                Publisher: Korean Stroke Society
                ISSN (Print): 2287-6391
                ISSN (Electronic): 2287-6405
                Publication date (Print): May 2014
                Publication date (Electronic): 30 May 2014
                Volume: 16
                Issue: 2
                Pages: 91-96
                Affiliations
                Department of Neurology, Kosin University College of Medicine, Busan, Korea.
                Author notes
                Correspondence: Kwangsoo Kim. Department of Neurology, Kosin University College of Medicine, 262 Gamcheon-ro, Seo-gu, Busan 602-703, Korea. Tel: +82-51-990-6274, Fax: +82-51-990-3077, nekim@ 123456ns.kosinmed.or.kr
                Article
                DOI: 10.5853/jos.2014.16.2.91
                PMC ID: 4060273
                PubMed ID: 24949315
                SO-VID: aeeb6e9a-a660-495d-846e-cd895e2baf85
                Copyright © Copyright © 2014 Korean Stroke Society
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 02 September 2013
                Date revision received : 01 November 2013
                Date accepted : 01 November 2013
                Categories
                Subject: Original Article

                Keywords: biomarker,cancer,ischemic stroke,risk factor
                Data availability:
                Keywords: biomarker, cancer, ischemic stroke, risk factor

                Comments

                Comment on this article

                scite_

                Similar content890

                See all similar

                Cited by26

                See all cited by

                Most referenced authors309

                See all reference authors