Pedobarography: a novel approach to test the efficacy of treatments for lameness; an experience with mavacoxib in dogs with elbow osteoarthritis

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Abstract

Background

Pedobarographic analyses detect pressure redistribution among limbs and within limbs in humans, equids and dogs. The main objective of this study was to assess the usefulness of a set of pedobarographic parameters for the detection of lameness, as well as for its suitability for assessing the effects of therapies against osteoarthritis in dogs. With this purpose, eleven large-breed lame dogs with unilateral osteoarthritis due to elbow dysplasia were evaluated using a pressure platform prior to (D0) and after 3 months (D90) of treatment with mavacoxib, a COX-2 selective NSAID. The obtained parameters were: pressure distribution between lame and sound limbs, as well as paw area, mean pressure, and peak pressure of both lame and sound limbs.

Results

The results showed statistical differences in all these parameters between lame and sound limbs at D0; however, at D90, differences were significantly decreased as result of the treatment, indicating a substantial functional recovery under the study design conditions.

Conclusions

The provided data prove the suitability of this novel technique in canine models for the quantitative and objective assessment of lameness, but also for the evaluation of treatments for lameness caused by articular pain.

Electronic supplementary material

The online version of this article (10.1186/s12917-019-1946-1) contains supplementary material, which is available to authorized users.

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Most cited references 30

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Assessing repeatability and validity of a visual analogue scale questionnaire for use in assessing pain and lameness in dogs.

Sharon Kerwin, L. Taylor, M. Slater … (2004)

To develop a visual analogue scale (VAS) questionnaire that is repeatable and valid for use in assessing pain and lameness in dogs. 48 client-owned dogs with mild to moderate lameness. The dogs were from 3 studies conducted during a 3-year period. Of the 48 dogs, 19 were used in repeatability assessment, 48 were used in principal component analysis, and 44 were used in model selection procedures and validity testing. A test-retest measure of repeatability was conducted on dogs with a change of 0.6. Model selection procedures resulted in 3 overlapping subsets of questions that were considered valid representations of the forces measured (vertical peak, vertical impulse, and propulsion peak). Each reduced model fit the data as well as the full model. The VAS questionnaire was repeatable and valid for use in assessing the degree of mild to moderate lameness in dogs.

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Evaluation of agreement between numerical rating scales, visual analogue scoring scales, and force plate gait analysis in dogs.

Maria Faria, Yan Lu, Andrew Quinn … (2007)

To evaluate the accuracy of numerical rating (NRS) and visual analogue (VAS) scoring scales compared with force plate gait analysis and agreement between observers for each scoring scale. Experimental study. Mixed breed dogs (n=21) with a right limb tibial osteotomy repaired with an external fixator. Three small-animal veterinarians with orthopedic training scored lameness using NRS and VAS before surgery, and at 4 and 8 weeks after surgery. Peak force and impulse were determined at the same time points using a force plate. Agreement between observers and with force plate data was assessed. Significance was set at P< or =.05. Agreement was generally low among observers for both NRS and VAS scores. When evaluated at each time point, an acceptable level of agreement was present only at 4 weeks after surgery. Only impulse had a significant relationship with some of the observers' subjective scores. No significant relationships between any observer's scores and force plate data existed if very lame dogs were omitted. Subjective scoring scales do not replace force plate gait analysis. Agreement is low unless lameness is severe, and each observer uses an individually unique scale. Subjective scoring scales most accurately reflect force plate gait analysis when lameness is severe. Subjective lameness scoring scales may not accurately reflect lameness and do not replace force plate gait analysis. Observers must stay the same during the duration of a study for accurate analyses.

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Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis.

Lori Dodd, T Allen, K Roush … (2010)

To evaluate the effects of a food supplemented with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis. Randomized, double-blinded, controlled clinical trial. 38 client-owned dogs with osteoarthritis examined at 2 university veterinary clinics. Dogs were randomly assigned to receive a typical commercial food (n = 16) or a test food (22) containing 3.5% fish oil omega-3 fatty acids. On day 0 (before the trial began) and days 45 and 90 after the trial began, investigators conducted orthopedic evaluations and force-plate analyses of the most severely affected limb of each dog, and owners completed questionnaires to characterize their dogs' arthritis signs. The change in mean peak vertical force between days 90 and 0 was significant for the test-food group (5.6%) but not for the control-food group (0.4%). Improvement in peak vertical force values was evident in 82% of the dogs in the test-food group, compared with 38% of the dogs in the control-food group. In addition, according to investigators' subjective evaluations, dogs fed the test food had significant improvements in lameness and weight bearing on day 90, compared with measurements obtained on day 0. At least in the short term, dietary supplementation with fish oil omega-3 fatty acids resulted in an improvement in weight bearing in dogs with osteoarthritis.

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Author and article information

Contributors

Sergio López: sergiolopezbarbeta@gmail.com

José M. Vilar:

ORCID: http://orcid.org/0000-0002-2060-2274

+34-928457244 , jose.vilar@ulpgc.es

Mónica Rubio: mrubio@uchceu.es

Joaquín J. Sopena: jsopena@uchceu.es

Angelo Santana: angelo@dma.ulpgc.es

Oliver Rodríguez: oliver.rodriguez@ulpgc.es

José A. Rodríguez-Altonaga: jarodma@unileon.es

José M. Carrillo: jcarrillo@uchceu.es

Journal

Journal ID (nlm-ta): BMC Vet Res

Journal ID (iso-abbrev): BMC Vet. Res

Title: BMC Veterinary Research

Publisher: BioMed Central (London )

ISSN (Electronic): 1746-6148

Publication date (Electronic): 11 June 2019

Publication date PMC-release: 11 June 2019

Publication date Collection: 2019

Volume: 15

Electronic Location Identifier: 193

Affiliations

[1 ]ISNI 0000 0004 1769 9380, GRID grid.4521.2, Departamento de Patología Animal, , Universidad de las Palmas de Gran Canaria, ; Arucas, Las Palmas, Spain

[2 ]ISNI 0000 0004 1769 9380, GRID grid.4521.2, Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Universidad de las Palmas de Gran Canaria, ; Arucas, Las Palmas, Spain

[3 ]ISNI 0000 0004 1769 4352, GRID grid.412878.0, Departamento Medicina y Cirugía Animal, , Cátedra García Cugat, Universidad CEU Cardenal Herrera, ; Valencia, Spain

[4 ]ISNI 0000 0004 1769 9380, GRID grid.4521.2, Departamento de Matemáticas, , Universidad de las Palmas de Gran Canaria, ; Las Palmas, Spain

[5 ]ISNI 0000 0001 2187 3167, GRID grid.4807.b, Departamento de Medicina, Cirugía y Anatomía Veterinaria, , Universidad de León, ; León, Spain

Author information

José M. Vilar http://orcid.org/0000-0002-2060-2274

Article

Publisher ID: 1946

DOI: 10.1186/s12917-019-1946-1

PMC ID: 6560748

PubMed ID: 31186043

SO-VID: adcd28f8-78bb-4762-bbd3-f842bc79eef2

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

History

Date received : 21 May 2018

Date accepted : 4 June 2019

Custom metadata

ScienceOpen disciplines: Veterinary medicine

Keywords: balance,pedobarography,dog,mean pressure,peak pressure,paw,lameness, cop (center of pressure)

Data availability:

ScienceOpen disciplines: Veterinary medicine

Keywords: balance, pedobarography, dog, mean pressure, peak pressure, paw, lameness, cop (center of pressure)

Pedobarography: a novel approach to test the efficacy of treatments for lameness; an experience with mavacoxib in dogs with elbow osteoarthritis

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Horses and Humans Research Foundation

Most cited references 30

Assessing repeatability and validity of a visual analogue scale questionnaire for use in assessing pain and lameness in dogs.

Evaluation of agreement between numerical rating scales, visual analogue scoring scales, and force plate gait analysis in dogs.

Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis.

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