Ethanol extracts of Rehmannia complex (Di Huang) containing no Corni fructus improve early diabetic nephropathy by combining suppression on the ET-ROS axis with modulate hypoglycemic effect in rats.

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Abstract

Liuwei Dihuang (Rehmannia complex, RC) decoction, a classic prescription of Traditional Chinese Medicine (TCM), has been used in treating diabetic nephropathy (DN). Among the 6 crude medicines which contains Corni fructus is recognized as the active fraction for its effectiveness. We aimed to investigate, first, if without Corni fructus a modified RC could be still effective, second, if the ethanol extracts could be better than that of water extract and third, the beneficial effect is mainly stemmed from suppressing the endothelin (ET-1) pathway associated with a moderate hypoglycemic effect.

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Journal

Journal ID (iso-abbrev): J Ethnopharmacol

Title: Journal of ethnopharmacology

Publisher: Elsevier BV

ISSN: 0378-8741

ISSN (Print): 0378-8741

Publication date (Electronic): Aug 13 2008

Volume: 118

Issue: 3

Affiliations

[1 ] Research Division of Pharmacology, China Pharmaceutical University, Nanjing, China.

Article

Publisher Item ID: S0378-8741(08)00274-2

DOI: 10.1016/j.jep.2008.05.015

PubMed ID: 18585879

SO-VID: ac16b696-b1ad-4228-bbc6-1abc1aec2c14

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