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      The vagus nerve and the inflammatory reflex--linking immunity and metabolism.

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          Abstract

          The vagus nerve has an important role in regulation of metabolic homeostasis, and efferent vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory responses via the inflammatory reflex. Dysregulation of metabolism and immune function in obesity are associated with chronic inflammation, a critical step in the pathogenesis of insulin resistance and type 2 diabetes mellitus. Cholinergic mechanisms within the inflammatory reflex have, in the past 2 years, been implicated in attenuating obesity-related inflammation and metabolic complications. This knowledge has led to the exploration of novel therapeutic approaches in the treatment of obesity-related disorders.

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          Author and article information

          Journal
          Nat Rev Endocrinol
          Nature reviews. Endocrinology
          Springer Science and Business Media LLC
          1759-5037
          1759-5029
          Dec 2012
          : 8
          : 12
          Affiliations
          [1 ] Center for Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA. vpavlov@nshs.edu
          Article
          nrendo.2012.189 NIHMS488460
          10.1038/nrendo.2012.189
          4082307
          23169440
          ab8eca1b-9379-4ed6-bdd0-1d622b97385b
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