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      The vagus nerve and the inflammatory reflex--linking immunity and metabolism.

      Nature reviews. Endocrinology
      Animals, Diabetes Mellitus, Type 2, immunology, metabolism, Homeostasis, physiology, Humans, Inflammation, Metabolic Networks and Pathways, Obesity, Reflex, Signal Transduction, Vagus Nerve

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          Abstract

          The vagus nerve has an important role in regulation of metabolic homeostasis, and efferent vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory responses via the inflammatory reflex. Dysregulation of metabolism and immune function in obesity are associated with chronic inflammation, a critical step in the pathogenesis of insulin resistance and type 2 diabetes mellitus. Cholinergic mechanisms within the inflammatory reflex have, in the past 2 years, been implicated in attenuating obesity-related inflammation and metabolic complications. This knowledge has led to the exploration of novel therapeutic approaches in the treatment of obesity-related disorders.

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          Journal
          23169440
          4082307
          10.1038/nrendo.2012.189

          Chemistry
          Animals,Diabetes Mellitus, Type 2,immunology,metabolism,Homeostasis,physiology,Humans,Inflammation,Metabolic Networks and Pathways,Obesity,Reflex,Signal Transduction,Vagus Nerve

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