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      Bisphenol A in Selected South African Water Sources: A Critical Review

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          Abstract

          Bisphenol A (BPA) is a pollutant that has gained the attention of scientists globally because of its ubiquity in environmental matrices as well as its toxicity in the environment. It is listed as a priority pollutant in South Africa, capable of health risk impacts, which, according to the European Union, should not exceed 2.5 μg/L in water. In South Africa, historical data on its environmental occurrence is sparingly available, although research on BPA and other endocrine disruptors is currently gaining momentum. Surface, ground, and wastewater constitute the major proportion of the water sources that are prone to contamination by emerging pollutants such as BPA. In order to gain a holistic perspective of this chemical, a detailed review was carried out using over five hundred peer-reviewed articles that investigated the occurrence of BPA in South African aquatic systems. This study shows that Gauteng and Western Cape are the Provinces with the highest reported number of BPA occurrences in water. The data also shows that surface water constitutes 41% of all BPA articles while matrices like ponds and lagoons have no recorded studies. Its presence was attributed to anthropogenic activities such as the generation of domestic, agricultural, and industrial waste. Local application of removal techniques such as adsorption and photocatalysis on laboratory and field samples has shown good prospects (especially photocatalysis) in mitigating current challenges related to the occurrence of BPA. However, there is room for more innovative initiatives. Although there is a ban on the use of BPA for making baby bottles, additional regulations can be put in place regarding the use of BPA in making plastics or other packaging materials from which BPA can leach.

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          Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes

          Background Increasing concern over bisphenol A (BPA) as an endocrine-disrupting chemical and its possible effects on human health have prompted the removal of BPA from consumer products, often labeled “BPA-free.” Some of the chemical replacements, however, are also bisphenols and may have similar physiological effects in organisms. Bisphenol S (BPS) and bisphenol F (BPF) are two such BPA substitutes. Objectives This review was carried out to evaluate the physiological effects and endocrine activities of the BPA substitutes BPS and BPF. Further, we compared the hormonal potency of BPS and BPF to that of BPA. Methods We conducted a systematic review based on the Office of Health Assessment and Translation (OHAT) protocol. Results We identified the body of literature to date, consisting of 32 studies (25 in vitro only, and 7 in vivo). The majority of these studies examined the hormonal activities of BPS and BPF and found their potency to be in the same order of magnitude and of similar action as BPA (estrogenic, antiestrogenic, androgenic, and antiandrogenic) in vitro and in vivo. BPS also has potencies similar to that of estradiol in membrane-mediated pathways, which are important for cellular actions such as proliferation, differentiation, and death. BPS and BPF also showed other effects in vitro and in vivo, such as altered organ weights, reproductive end points, and enzyme expression. Conclusions Based on the current literature, BPS and BPF are as hormonally active as BPA, and they have endocrine-disrupting effects. Citation Rochester JR, Bolden AL. 2015. Bisphenol S and F: a systematic review and comparison of the hormonal activity of bisphenol A substitutes. Environ Health Perspect 123:643–650; http://dx.doi.org/10.1289/ehp.1408989
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            The adverse health effects of bisphenol A and related toxicity mechanisms

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              The fate of pharmaceuticals and personal care products (PPCPs), endocrine disrupting contaminants (EDCs), metabolites and illicit drugs in a WWTW and environmental waters.

              A large number of emerging contaminants (ECs) are known to persist in surface waters, and create pressure on wastewater treatment works (WWTW) for their effective removal. Although a large database for the levels of these pollutants in water systems exist globally, there is still a lack in the correlation of the levels of these pollutants with possible long-term adverse health effects in wildlife and humans, such as endocrine disruption. The current study detected a total of 55 ECs in WWTW influent surface water, 41 ECs in effluent, and 40 ECs in environmental waters located upstream and downstream of the plant. A list of ECs persisted through the WWTW process, with 28% of all detected ECs removed by less than 50%, and 18% of all ECs were removed by less than 25%. Negative mass balances of some pharmaceuticals and metabolites were observed within the WWTW, suggesting possible back-transformation of ECs during wastewater treatment. Three parental illicit drug compounds were detected within the influent of the WWTW, with concentrations ranging between 27.6 and 147.0 ng L(-1) for cocaine, 35.6-120.6 ng L(-1) for mephedrone, and 270.9-450.2 ng L(-1) for methamphetamine. The related environmental risks are also discussed for some ECs, with particular reference to their ability to disrupt endocrine systems. The current study propose the potential of the pharmaceuticals carbamazepine, naproxen, diclofenac and ibuprofen to be regarded as priority ECs for environmental monitoring due to their regular detection and persistence in environmental waters and their possible contribution towards adverse health effects in humans and wildlife.
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                Author and article information

                Journal
                ACS Omega
                ACS Omega
                ao
                acsodf
                ACS Omega
                American Chemical Society
                2470-1343
                16 February 2025
                25 February 2025
                : 10
                : 7
                : 6279-6293
                Affiliations
                []Department of Geography and Environmental Sciences, University of Venda , Thohoyandou 0950, South Africa
                []College of Science, Engineering and Technology, Institute for Nanotechnology and Water Sustainability, Florida Science Campus, University of South Africa , 1709 Johannesburg, South Africa
                [§ ]Department of Science Laboratory Technology (Chemistry Unit), Yaba College of Technology , P.M.B. 2011, Yaba, Lagos 101212, Nigeria
                Author notes
                Author information
                https://orcid.org/0000-0002-9846-2953
                Article
                10.1021/acsomega.4c01686
                11866014
                a9cb3f3d-cca9-4194-b41b-79c19908fe25
                © 2025 The Authors. Published by American Chemical Society

                Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works ( https://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 21 February 2024
                : 31 December 2024
                : 23 December 2024
                Funding
                Funded by: University of Venda, doi 10.13039/501100008976;
                Award ID: NA
                Categories
                Review
                Custom metadata
                ao4c01686
                ao4c01686

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