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Anthracene-Polyamine Conjugates Inhibit In Vitro Proliferation of Intraerythrocytic Plasmodium falciparum Parasites
J. Niemand ,
P. Burger ,
B. K. Verlinden ,
J. Reader ,
A. M. Joubert ,
A. Kaiser ,
A. I. Louw ,
K. Kirk ,
O. Phanstiel ,
L.-M. Birkholtz
May 14 2013
April 01 2013
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Abstract
Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic
human malaria parasite Plasmodium falciparum, with 50% inhibitory concentrations (IC50s)
in the nM to μM range. The compounds are taken up into the intraerythrocytic parasite,
where they arrest the parasite cell cycle. Both the anthracene and polyamine components
of the conjugates play a role in their antiplasmodial effect.