Effects of cold or warm ischemia and ex-vivo lung perfusion on the release of damage associated molecular patterns and inflammatory cytokines in experimental lung transplantation.

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Abstract

Lung transplantation (LTx) is associated with sterile inflammation, possibly related to the release of damage associated molecular patterns (DAMPs) by injured allograft cells. We have measured cellular damage and the release of DAMPs and cytokines in an experimental model of LTx after cold or warm ischemia and examined the effect of pretreatment with ex-vivo lung perfusion (EVLP).

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Journal

Journal ID (iso-abbrev): J Heart Lung Transplant

Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Publisher: Elsevier BV

ISSN (Electronic): 1557-3117

ISSN (Print): 1053-2498

Publication date (Electronic): September 2021

Volume: 40

Issue: 9

Affiliations

[1 ] Service of Thoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland.

[2 ] Service of Thoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland; Service of Thoracic Surgery and Department of Adult Intensive Care Medicine, Lausanne University Hospital, Lausanne, Switzerland.

[3 ] Service of Thoracic Surgery and Department of Adult Intensive Care Medicine, Lausanne University Hospital, Lausanne, Switzerland.

[4 ] Department of Adult Intensive Care Medicine, Lausanne University Hospital, Lausanne, Switzerland.

[5 ] Department of Pharmacology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.

[6 ] Department of Adult Intensive Care Medicine, Lausanne University Hospital, Lausanne, Switzerland. Electronic address: lucas.liaudet@chuv.ch.

Article

Publisher Item ID: S1053-2498(21)02330-5

DOI: 10.1016/j.healun.2021.05.015

PubMed ID: 34193360

SO-VID: a964e7bc-4e7c-44fe-aae0-1ca697f0ae24

History

Keywords: Lung Transplantation,Animal model,Ex-vivo lung perfusion,Inflammation,Innate immunity

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Keywords: Lung Transplantation, Animal model, Ex-vivo lung perfusion, Inflammation, Innate immunity

Effects of cold or warm ischemia and ex-vivo lung perfusion on the release of damage associated molecular patterns and inflammatory cytokines in experimental lung transplantation.

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Abstract

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Biomarkers for Inflammatory Lung Disease

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