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      A minor tweak in transplant surgery protocols alters the cellular landscape of the arterial wall during transplant vasculopathy

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          Abstract

          Introduction

          Transplant vasculopathy (TV) is a major complication after solid organ transplantation, distinguished by an arterial intimal thickening that obstructs the vascular lumen and leads to organ rejection. To date, TV remains largely untreatable, mainly because the processes involved in its development remain unclear. Aortic transplantation in mice, used to mimic TV, relies on highly variable experimental protocols, particularly regarding the type of anastomosis used to connect the donor aorta to the recipient. While the amount of trauma undergone by a vessel can dramatically affect the resulting pathology, the impact of the type of anastomosis on TV in mice has not been investigated in detail.

          Methods

          In this study, we compare the cellular composition of aortic grafts from BALB/C donor mice transplanted into C57BL/6J recipient mice using two different anastomosis strategies: sleeve and cuff.

          Results

          While both models recapitulated some aspects of human TV, there were striking differences in the cellular composition of the grafts. Indeed, aortic grafts from the cuff group displayed a larger coverage of the neointimal area by vascular smooth muscle cells compared to the sleeve group. Aortic grafts from the sleeve group contained higher amounts of T cells, while the cuff group displayed larger B-cell infiltrates.

          Discussion

          Together, these data indicate that a seemingly minor technical difference in transplant surgery protocols can largely impact the cellular composition of the graft, and thus the mechanisms underlying TV after aortic transplantation in mice.

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          Most cited references49

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          MorphoLibJ: integrated library and plugins for mathematical morphology with ImageJ.

          Philippe Andrey, David Legland, Ignacio Arganda-Carreras (2016)
          Mathematical morphology (MM) provides many powerful operators for processing 2D and 3D images. However, most MM plugins currently implemented for the popular ImageJ/Fiji platform are limited to the processing of 2D images.
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            A 2018 Reference Guide to the Banff Classification of Renal Allograft Pathology

            Candice A. Roufosse, Naomi Simmonds, Marian C. Clahsen-van Groningen … (2018)
            Abstract The Banff Classification of Allograft Pathology is an international consensus classification for the reporting of biopsies from solid organ transplants. Since its initial conception in 1991 for renal transplants, it has undergone review every 2 years, with attendant updated publications. The rapid expansion of knowledge in the field has led to numerous revisions of the classification. The resultant dispersal of relevant content makes it difficult for novices and experienced pathologists to faithfully apply the classification in routine diagnostic work and in clinical trials. This review shall provide a complete and simple illustrated reference guide of the Banff Classification of Kidney Allograft Pathology based on all publications including the 2017 update. It is intended as a concise desktop reference for pathologists and clinicians, providing definitions, Banff Lesion Scores and Banff Diagnostic Categories. An online website reference guide hosted by the Banff Foundation for Allograft Pathology (www.banfffoundation.org) is being developed, which will be updated with future refinement of the Banff Classification from 2019 onward.
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              Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis Models

              Joel Chappell, Jennifer L. Harman, Vagheesh M. Narasimhan … (2016)
              Supplemental Digital Content is available in the text.
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                Author and article information

                Contributors
                Laura Mickiewicz: URI : https://loop.frontiersin.org/people/2611293/overviewRole: Role: Role: Role: Role: Role: Role: Role: Role:
                Rana Zahreddine: URI : https://loop.frontiersin.org/people/1482290/overviewRole: Role:
                Kévin Cormier: Role: Role:
                Sophie Peries: Role: Role:
                Arnaud Del Bello: URI : https://loop.frontiersin.org/people/803254/overviewRole: Role: Role: Role:
                Muriel Laffargue: URI : https://loop.frontiersin.org/people/776247/overviewRole: Role: Role: Role: Role: Role:
                Natalia F. Smirnova: URI : https://loop.frontiersin.org/people/2210160/overviewRole: Role: Role: Role: Role: Role: Role: Role: Role: Role:
                Journal
                Journal ID (nlm-ta): Front Transplant
                Journal ID (iso-abbrev): Front Transplant
                Journal ID (publisher-id): Front. Transplant.
                Title: Frontiers in Transplantation
                Publisher: Frontiers Media S.A.
                ISSN (Electronic): 2813-2440
                Publication date (Electronic): 29 April 2024
                Publication date Collection: 2024
                Volume: 3
                Electronic Location Identifier: 1260125
                Affiliations
                [ 1 ]Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut National de la Santé et de la Recherche Médicale (INSERM) U1297, University of Toulouse 3 , Toulouse, France
                [ 2 ]CREFRE-Anexplo, Services Phénotypage et Microchirurgie, UMS006, INSERM, Université de Toulouse, UT3, ENVT , Toulouse, France
                [ 3 ]Center for Biological Ressources (Centres de Ressources Biologiques, CRB), IUCT Oncopole, Toulouse University Hospital (CHU de Toulouse) , Toulouse, France
                [ 4 ]Department of Nephrology and Organ Transplantation, Toulouse University Hospital (CHU de Toulouse) , Toulouse, France
                Author notes

                Edited by: Alessandro Alessandrini, Massachusetts General Hospital and Harvard Medical School, United States

                Reviewed by: Jane O, Massachusetts General Hospital and Harvard Medical School, United States

                Johannes Wedel, Boston Children’s Hospital, United States

                [* ] Correspondence: Natalia F. Smirnova natalia.smirnova@ 123456inserm.fr
                Article
                DOI: 10.3389/frtra.2024.1260125
                PMC ID: 11235260
                PubMed ID: 38993774
                SO-VID: a797bf03-f612-4819-951c-8088080370fa
                Copyright © © 2024 Mickiewicz, Zahreddine, Cormier, Peries, Del Bello, Laffargue and Smirnova.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                Date received : 17 July 2023
                Date accepted : 02 April 2024
                Page count
                Figures: 5, Tables: 1, Equations: 0, References: 50, Pages: 0, Words: 0
                Funding
                Funded by: Agence Nationale de la Recherche
                Award ID: ANR-22-CE14-0012
                Funded by: Fondation pour la Recherche Médicale
                Award ID: PME202106013863
                The authors declare that financial support was received for the research, authorship, and/or publication of this article.
                This study was supported by funding from Agence Nationale de la Recherche (ANR-22-CD14-0012), Fondation pour la Recherche Médicale (PME202106013863) and INSERM.
                Categories
                Subject: Transplantation
                Subject: Original Research
                Custom metadata
                section-at-acceptance Transplantation Immunology

                Keywords: transplantation,surgery,anastomosis,vascular wall,transplant vasculopathy
                Data availability:
                Keywords: transplantation, surgery, anastomosis, vascular wall, transplant vasculopathy

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