Introduction
Common cutaneous warts caused by human papillomavirus (HPV) strains 1, 2, and 4, can
be challenging to treat. Immunosuppressed patients are especially vulnerable to this
infection, and the warts may cause physical and psychologic distress. There are currently
3 commercially available vaccines in the United States that target HPV strains commonly
associated with the development of anogenital warts, cervical dysplasia, and cervical,
vulvar, vaginal, and anal cancers. We report a case of an immunosuppressed adult with
eruptive cutaneous warts who responded well to treatment with the nonavalent HPV vaccine
(targeted against HPV 6, 11, 16, 18, 31, 33, 45, 52 and 58).
1
Case report
A 77 year-old white man with a long-term history of immunosuppression presented with
a 6-month history of pruritic and eruptive white papules on the trunk and extremities.
His medical history was significant for ulcerative colitis treated with long-term
6-mercaptopurine, 75 mg daily, and mesalamine, up to 800 mg 3 times daily, and a history
of occasional cutaneous warts, totaling less than 7 at any time at previous dermatologic
visits in the preceding 5 years. His warts had been treated with liquid nitrogen and
salicylic acid and occasionally shave removal. The patient had no risk factors for
HIV.
On examination recently, the patient had more than 70 inflamed thick, scaly white
plaques ranging in size from 2 to 20 mm on the trunk and extremities clinically consistent
with warts (Fig 1, A and B). Initial management included shave removal of 6 larger,
more cumbersome lesions and freezing of more than 20 smaller areas with liquid nitrogen.
Pathology findings for each sample were consistent with verruca. HPV typing was not
performed because of cost.
Fig 1
A and B, Lower legs at baseline highlighting many inflamed warts.
At follow-up 2 weeks later, the patient complained of continuing to develop new itchy
white bumps. Different alternative treatments were discussed including the possibility
of administering the HPV vaccine, based on several case reports of successful treatment
of recalcitrant cutaneous warts.2, 3, 4, 5 The patient elected to try the nonavalent
HPV vaccine and it was given at baseline and 2 and 6 months later. No additional treatments
were performed during the vaccine period. The patient noticed a decrease in his warts
and his level of pruritus within the first 3 weeks. Photos were obtained with the
patient's permission at baseline and 6 months. The number of cutaneous warts dramatically
decreased from the time of the initial vaccine administration to the 6-month time
point (Fig 2, A and B). The warts did not fully clear, but the number of warts decreased
over time without a change in his immunosuppressive medications, down to a low of
3 warts 15 months after the initial vaccine dose.
Fig 2
A and B, Lower legs 6 months after the HPV vaccine series was initiated (seen at his
appointment for the third and final vaccine administration).
Discussion
Routine vaccination against HPV has been available in most industrialized countries
since 2006. First available as bivalent and quadrivalent vaccines, the nonavalent
vaccine has been available since 2015.
6
It is targeted against HPV 6, 11, 16, 18, 31, 33, 45, 52, and 58 and for those older
than 15 years, the recommended dosing schedule is at zero, 2, and 6 months.
6
It has been shown to produce a robust immune response with seroconversion rates approaching
100%.
1
Studies on HPV vaccine administration in immunosuppressed populations are sparse,
but a multicenter trial did show adequate immunogenic response to quadrivalent vaccine
administration in immunosuppressed children regardless of age or cause of immunosuppression.
7
Recalcitrant common warts, especially in the immunosuppressed population, can prove
to be difficult to treat. Although many therapeutic options for warts exist, there
is no definitive cure. Several case reports have described the successful use of quadrivalent
HPV vaccine in treating recalcitrant warts.2, 3, 4, 5 Within the body of literature
surrounding HPV vaccines, there is some indication for a cross-protection effect against
HPV strains other than those targeted by the individual vaccine administered.8, 9,
10 Although the HPV strains that cause common warts may be less genetically related
to those implicated in cervical, vulvar, and anal cancer, the possibility of cross-over
effects with vaccines has been postulated previously.2, 3, 4 Interestingly, one case
series reported success in treating children less than 14 years old with the quadrivalent
vaccine, but less improvement was noted in teenagers (3 of 6 patients cleared) and
in adults (1 of 4 patients cleared), perhaps indicating a more robust response to
the vaccine in children.
4
Our patient quickly experienced both a decrease in the number of warts and decreased
irritation by the warts after the initial administration of the nonavalent HPV vaccine.
His warts did not fully clear by 6 months, as has been reported when previously describing
good responses to HPV vaccine.2, 3, 4, 5 This finding may indicate a cross-protection
effect for certain but not all of his HPV strains. We did not perform HPV typing in
this case because of patient cost; however, HPV status has been previously examined
in a case report showing clearance of cutaneous warts negative for HPV 6, 11, 16,
and 18 but positive for a general probe for HPV.
3
Warts can spontaneously regress, and we cannot be certain that the vaccine played
a role in the clearance of our patient's warts or in the previously reported cases.
However, our patient saw a dramatic improvement in quality of life after administration
of this vaccine. HPV vaccine administration should be considered a potential treatment
alternative for recalcitrant warts in the immunosuppressed population. More specifically,
our case provides evidence that the nonavalent vaccine may help decrease the morbidity
associated with recalcitrant warts in this population.