The Association of rs4753426 Polymorphism in the Melatonin Receptor 1B (MTNR1B) Gene and Susceptibility to Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-analysis.

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Abstract

Adolescent idiopathic scoliosis (AIS) is a tridimensional structural deformity of the spine that may deteriorate progressively, leading to significant functional limitations and pain problems. Several previous studies have implicated the rs4753426 single nucleotide polymorphism in the melatonin receptor 1B (MTNR1B) gene in the etiology of AIS. However the sample sizes were limited and the findings of those studies were inconsistent. An overall assessment of the evidence supporting this association has not been previously conducted.

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Journal

Journal ID (iso-abbrev): Pain Physician

Title: Pain physician

ISSN (Electronic): 2150-1149

ISSN (Print): 1533-3159

Publication date (Electronic): October 3 2015

Volume: 18

Issue: 5

Affiliations

[1 ] Department of Orthopaedic Surgery The First Affiliated Hospital of Soochow University 188 Shizi Street, Suzhou, Jiangsu, China.

Article

PubMed ID: 26431121

SO-VID: a5c93d0d-04ac-4d31-ab55-bd3a29603398

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