Identification and validation of HOXD3 and UNC5C as molecular signatures in keloid based on weighted gene co-expression network analysis.

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Abstract

Keloid is a benign proliferative disease characterized by excessive deposition of extracellular matrix collagen during skin wound healing. The mechanisms of keloid formation have not been fully elucidated, and the current treatment methods are not effective for all keloid patients. Therefore, there is an urgent need to find more effective therapies, and our research focused on identifying characteristic molecular signatures of keloid to explore potential therapeutic targets.

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Author and article information

Journal

Journal ID (iso-abbrev): Genomics

Title: Genomics

Publisher: Elsevier BV

ISSN (Electronic): 1089-8646

ISSN (Print): 0888-7543

Publication date (Electronic): Jul 2022

Volume: 114

Issue: 4

Affiliations

[1 ] Department of Burn Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, People's Republic of China. Electronic address: wanghw56@mail.sysu.edu.cn.

[2 ] Department of Burn Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, People's Republic of China. Electronic address: zhouzih2@mail2.sysu.edu.cn.

[3 ] Department of Burn Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, People's Republic of China.

[4 ] Department of Burn Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, People's Republic of China. Electronic address: wangp276@mail.sysu.edu.cn.

[5 ] Department of Burn Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, People's Republic of China. Electronic address: chenlei8@mail.sysu.edu.cn.

[6 ] Department of Burn Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, People's Republic of China. Electronic address: xiejulin@mail.sysu.edu.cn.

[7 ] Department of Burn Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, People's Republic of China. Electronic address: tangjinm@mail.sysu.edu.cn.

Article

Publisher Item ID: S0888-7543(22)00148-3

DOI: 10.1016/j.ygeno.2022.110403

PubMed ID: 35709926

SO-VID: a574457d-6e9f-481f-864e-2ae395e1585f

History

Keywords: Keloid,WGCNA,LASSO,Immune infiltration,Characteristic genes

Data availability:

Keywords: Keloid, WGCNA, LASSO, Immune infiltration, Characteristic genes

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