Up-regulation of tension-related proteins in keloids: knockdown of Hsp27, α2β1-integrin, and PAI-2 shows convincing reduction of extracellular matrix production.

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Abstract

Keloid disease is a fibroproliferative disorder, with an ill-defined treatment that is characterized by excessive extracellular matrix deposition. Mechanical tension promotes deposition of extracellular matrix and overexpression of tension-related proteins, which is associated with keloid disease. The aim of this study was to investigate the effect of tension-related proteins on extracellular matrix steady-state synthesis in primary keloid fibroblasts.

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Journal

Journal ID (iso-abbrev): Plast Reconstr Surg

Title: Plastic and reconstructive surgery

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1529-4242

ISSN (Print): 0032-1052

Publication date (Electronic): Feb 2013

Volume: 131

Issue: 2

Affiliations

[1 ] Manchester, United Kingdom From Plastic and Reconstructive Surgery Research, School of Translational Medicine, Manchester Institute of Biotechnology, and the Bioengineering Group, School of Mechanical, Aerospace, and Civil Engineering, University of Manchester, and the University Hospital of South Manchester NHS Foundation Trust, Faculty of Medical and Human Sciences, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre.

Article

Publisher Item ID: 00006534-201302000-00008

DOI: 10.1097/PRS.0b013e3182789b2b

PubMed ID: 23358011

SO-VID: 06aa1be8-3dc7-4901-8bec-70f89b4f4423

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