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      Mycobacterium mageritense Prosthetic Joint Infection

      case-report
      ,
      Case Reports in Infectious Diseases
      Hindawi

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          Abstract

          Prosthetic joint infections (PJI) complicate up to 2% of arthroplasties and are usually caused by typical bacterial agents (e.g., staphylococci and streptococci). Although an infrequent cause of PJI, mycobacterial species are difficult to eradicate, as they adhere to hardware, form biofilms, and have high rates of antimicrobial resistance. Mycobacterium mageritense is a rapidly growing Mycobacterium that has been infrequently described as a cause of surgical and device-related infections. We herein described a case of prosthetic knee infection due to M. mageritense. The patient was treated with removal of hardware, antimicrobials, and prosthetic knee reimplantation with a good outcome. To our knowledge, M. mageritense has not been previously described as a cause of PJI in the medical literature.

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          Most cited references11

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          Periprosthetic Joint Infection Is the Main Cause of Failure for Modern Knee Arthroplasty: An Analysis of 11,134 Knees.

          Although large series from national joint registries may accurately reflect indications for revision TKAs, they may lack the granularity to detect the true incidence and relative importance of such indications, especially periprosthetic joint infections (PJI).
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            Nontuberculous Mycobacteria: Skin and Soft Tissue Infections.

            Skin and soft tissue infections caused by nontuberculous mycobacteria are increasing in incidence. The nontuberculous mycobacteria are environmental, acid-fast bacilli that cause cutaneous infections primarily after trauma, surgery and cosmetic procedures. Skin findings include abscesses, sporotrichoid nodules or ulcers, but also less distinctive signs. Important species include Mycobacterium marinum and the rapidly growing mycobacterium: M. fortuitum, M. abscessus and M. chelonae. Obtaining tissue for mycobacterial culture and histopathology aids diagnosis. Optimal therapy is not well-established, but is species-dependent and generally dictated by susceptibility studies. Management often includes use of multiple antibiotics for several months and potential use of adjunctive surgery.
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              Rapidly Growing Mycobacteria.

              Rapidly growing mycobacteria (RGM) compose approximately one-half of the currently validated mycobacterial species and are divided into six major groups, including the Mycobacterium fortuitum group, M. chelonae/M. abscessus complex, M. smegmatis group, M. mucogenicum group, M. mageritense/M. wolinskyi, and the pigmented RGM. This review discusses each group and highlights the major types of infections associated with each group. Additionally, phenotypic and molecular laboratory identification methods, including gene sequencing, mass spectrometry, and the newly emerging whole-genome sequencing, are detailed, along with a discussion of the current antimicrobial susceptibility methods and patterns of the most common pathogenic species.
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                Author and article information

                Contributors
                Journal
                Case Rep Infect Dis
                Case Rep Infect Dis
                CRIID
                Case Reports in Infectious Diseases
                Hindawi
                2090-6625
                2090-6633
                2020
                11 July 2020
                : 2020
                : 8845430
                Affiliations
                Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550-0435, USA
                Author notes

                Academic Editor: Larry M. Bush

                Author information
                https://orcid.org/0000-0002-4653-2323
                Article
                10.1155/2020/8845430
                7369673
                32733720
                a4cd2347-9a9f-4534-bfc8-c55c8b1b6a5a
                Copyright © 2020 Maria A. Caravedo Martinez and Lucas S. Blanton.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 6 May 2020
                : 12 June 2020
                : 16 June 2020
                Categories
                Case Report

                Infectious disease & Microbiology
                Infectious disease & Microbiology

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