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      Factors influencing the utilization of Traditional Chinese Medicine in cancer treatment: a qualitative meta-synthesis of patient and healthcare professional perspectives

      systematic-review

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          Abstract

          Background

          The complementary role of Traditional Chinese Medicine (TCM) in cancer management has been widely acknowledged. However, its implementation continues to face numerous challenges. Identifying and elucidating the factors that influence the integration of TCM into cancer therapy is essential. Developing effective implementation strategies is crucial to transitioning from theoretical evidence to practical application.

          Methods

          A total of nine databases were systematically searched from their inception until 1 October 2023. The review includes qualitative and mixed-method studies examining the attitudes and perceptions of patients and healthcare providers toward the use of TCM in cancer treatment. The studies included were evaluated using a quality assessment tool. An appropriate model or framework was to identify potential facilitators and impediments affecting TCM implementation. Based on the identified barriers, potential behavior change interventions were subsequently developed.

          Results

          A total of 39 studies are included in the review, comprising 31 qualitative and eight mixed-methods studies. The quality of these studies is acceptable. Key barriers to the implementation of TCM were identified as follows: insufficient knowledge and experience in TCM, neglect of details in doctor-patient communication, limited number of specialists, lack of funding, and absence of a multidisciplinary collaborative atmosphere. In response to these barriers, we recommend improving structured referral pathways, developing a structured communication manual, and other targeted interventions to enhance the integration of TCM in cancer care.

          Conclusion

          This study identifies 48 factors that influence the implementation of TCM and tentatively proposes a series of intervention strategies. Future research should focus on localized empirical studies of factors and strategies in different healthcare settings.

          Systematic review registration

          https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=421822, identifier CRD42023421822.

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          Most cited references91

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          The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

          The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement, published in 2009, was designed to help systematic reviewers transparently report why the review was done, what the authors did, and what they found. Over the past decade, advances in systematic review methodology and terminology have necessitated an update to the guideline. The PRISMA 2020 statement replaces the 2009 statement and includes new reporting guidance that reflects advances in methods to identify, select, appraise, and synthesise studies. The structure and presentation of the items have been modified to facilitate implementation. In this article, we present the PRISMA 2020 27-item checklist, an expanded checklist that details reporting recommendations for each item, the PRISMA 2020 abstract checklist, and the revised flow diagrams for original and updated reviews.
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            The behaviour change wheel: A new method for characterising and designing behaviour change interventions

            Background Improving the design and implementation of evidence-based practice depends on successful behaviour change interventions. This requires an appropriate method for characterising interventions and linking them to an analysis of the targeted behaviour. There exists a plethora of frameworks of behaviour change interventions, but it is not clear how well they serve this purpose. This paper evaluates these frameworks, and develops and evaluates a new framework aimed at overcoming their limitations. Methods A systematic search of electronic databases and consultation with behaviour change experts were used to identify frameworks of behaviour change interventions. These were evaluated according to three criteria: comprehensiveness, coherence, and a clear link to an overarching model of behaviour. A new framework was developed to meet these criteria. The reliability with which it could be applied was examined in two domains of behaviour change: tobacco control and obesity. Results Nineteen frameworks were identified covering nine intervention functions and seven policy categories that could enable those interventions. None of the frameworks reviewed covered the full range of intervention functions or policies, and only a minority met the criteria of coherence or linkage to a model of behaviour. At the centre of a proposed new framework is a 'behaviour system' involving three essential conditions: capability, opportunity, and motivation (what we term the 'COM-B system'). This forms the hub of a 'behaviour change wheel' (BCW) around which are positioned the nine intervention functions aimed at addressing deficits in one or more of these conditions; around this are placed seven categories of policy that could enable those interventions to occur. The BCW was used reliably to characterise interventions within the English Department of Health's 2010 tobacco control strategy and the National Institute of Health and Clinical Excellence's guidance on reducing obesity. Conclusions Interventions and policies to change behaviour can be usefully characterised by means of a BCW comprising: a 'behaviour system' at the hub, encircled by intervention functions and then by policy categories. Research is needed to establish how far the BCW can lead to more efficient design of effective interventions.
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              The behavior change technique taxonomy (v1) of 93 hierarchically clustered techniques: building an international consensus for the reporting of behavior change interventions.

              CONSORT guidelines call for precise reporting of behavior change interventions: we need rigorous methods of characterizing active content of interventions with precision and specificity. The objective of this study is to develop an extensive, consensually agreed hierarchically structured taxonomy of techniques [behavior change techniques (BCTs)] used in behavior change interventions. In a Delphi-type exercise, 14 experts rated labels and definitions of 124 BCTs from six published classification systems. Another 18 experts grouped BCTs according to similarity of active ingredients in an open-sort task. Inter-rater agreement amongst six researchers coding 85 intervention descriptions by BCTs was assessed. This resulted in 93 BCTs clustered into 16 groups. Of the 26 BCTs occurring at least five times, 23 had adjusted kappas of 0.60 or above. "BCT taxonomy v1," an extensive taxonomy of 93 consensually agreed, distinct BCTs, offers a step change as a method for specifying interventions, but we anticipate further development and evaluation based on international, interdisciplinary consensus.
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                Author and article information

                Contributors
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                URI : http://loop.frontiersin.org/people/2180114/overviewRole: Role: Role: Role: Role: Role:
                URI : http://loop.frontiersin.org/people/2852811/overviewRole: Role: Role: Role: Role:
                Journal
                Front Med (Lausanne)
                Front Med (Lausanne)
                Front. Med.
                Frontiers in Medicine
                Frontiers Media S.A.
                2296-858X
                05 March 2025
                2025
                : 12
                : 1501918
                Affiliations
                [1] 1Department of Hematology and Oncology, Dongzhimen Hospital, Beijing University of Chinese Medicine , Beijing, China
                [2] 2Xuanwu Hospital, Capital Medical University , Beijing, China
                [3] 3Girton College, University of Cambridge , Cambridge, United Kingdom
                [4] 4Department of Pulmonary Medicine, FangShan Hospital, Beijing University of Chinese Medicine , Beijing, China
                [5] 5Department of Tuina and Pain Management, Dongzhimen Hospital, Beijing University of Chinese Medicine , Beijing, China
                [6] 6School of Life Sciences, Beijing University of Chinese Medicine , Beijing, China
                Author notes

                Edited by: Christian S. Kessler, Immanuel Hospital Berlin, Germany

                Reviewed by: Carolyn Ee, Western Sydney University, Australia

                Radhwan Hussein, Ninevah University, Iraq

                *Correspondence: Changhe Yu, yakno2@ 123456163.com

                These authors have contributed equally to this work and share first authorship

                Article
                10.3389/fmed.2025.1501918
                11920129
                40109719
                a44f8d05-de32-4c5d-a350-f1c4fc3ee1e3
                Copyright © 2025 Xu, Sun, Liu, Pan, Han, Zhang, Zhao, Li, Wu, Yu and Jiang.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 02 October 2024
                : 10 February 2025
                Page count
                Figures: 3, Tables: 3, Equations: 0, References: 93, Pages: 15, Words: 10434
                Funding
                Funded by: Beijing University of Chinese Medicine, doi 10.13039/501100004846;
                Award ID: 2022-JYB-JBZR-022
                The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by the National Natural Science Foundation of China (82374617), the National Natural Science Foundation of China for Young Scientists (81803956), the 2024 Beijing University of Chinese Medicine Double First-Class Discipline Project, the Capital Health Development Scientific Research Special Project (2020-4-4195). Additional support was provided by the Beijing University of Chinese Medicine Special Funding for Basic Research Operating Costs of Central Universities (No. 2022-JYB-JBZR-022).
                Categories
                Medicine
                Systematic Review
                Custom metadata
                Family Medicine and Primary Care

                traditional chinese medicine,meta-synthesis,integrated oncology,implementation barriers,modifiable determinants

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