Nodal Metastasis Count and Oncologic Outcomes in Head and Neck Cancer: A Secondary Analysis of NRG/RTOG 9501, NRG/RTOG 0234, and EORTC 22931.

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Abstract

A better understanding of the relationship between the spread of head and neck squamous cell carcinoma (HNSCC) to regional lymph nodes (LNs) and the frequency and manner of treatment failure should help design better treatment intensification strategies. In this study, we evaluated the relationship between recurrence patterns, mortality, and number of pathologically positive (+) LNs in HNSCC in 3 prospective randomized controlled trials.

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Journal

Journal ID (iso-abbrev): Int J Radiat Oncol Biol Phys

Title: International journal of radiation oncology, biology, physics

Publisher: Elsevier BV

ISSN (Electronic): 1879-355X

ISSN (Print): 0360-3016

Publication date (Electronic): Jul 15 2022

Volume: 113

Issue: 4

Affiliations

[1 ] Department of Radiation Oncology; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center.

[2 ] Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center; Department of Biostatistics and Bioinformatics, Cedars-Sinai Medical Center, Los Angeles, California.

[3 ] Genolier Innovation Network, Genolier, Switzerland; European Organisation for Research and Treatment of Cancer, Brussels, Belgium.

[4 ] NRG Oncology, Philadelphia, Pennsylvania.

[5 ] Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Wisconsin.

[6 ] NRG Oncology Statistical and Data Management Center, American College of Radiology, Philadelphia, Pennsylvania.

[7 ] Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California.

[8 ] Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center; Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California.

[9 ] Department of Radiation Oncology; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center. Electronic address: zachary.zumsteg@cshs.org.

Article

Mid ID: NIHMS1810684 Publisher Item ID: S0360-3016(22)00279-6

DOI: 10.1016/j.ijrobp.2022.03.033

PMC ID: 9583684

PubMed ID: 35395358

SO-VID: a3539306-1acd-44a9-9d84-7e93cc761e14

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