Berberine and its derivatives in collagen matrices as antimicrobial agents

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Abstract

The combination of collagen with natural plant compounds confers anti-inflammatory, antimicrobial, and antiviral activities to the polymeric material. These favorable properties enable broad-spectrum application of traditional, natural polymers in biomedicine. In the present study, natural fish collagen was combined with commercially available berberine (BBR) and naturally occurring protoberberine alkaloids obtained from the medicinal herb Chelidonium majus L (BBR-F). The incorporation of plant constituents into collagen matrices was confirmed by Raman spectroscopy. The antimicrobial properties of the plant-polymeric composites were assessed against typical pathogenic microorganisms ( Staphylococcus aureus, Escherichia coli, Candida albicans). The plant-based collagen matrices inhibited the growth of all the studied pathogens.

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The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

Anna Sorushanova, Luis Delgado, Zhuning Wu … (2019)

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Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives

Chanjuan Dong, Yonggang Lv (2016)

Collagen is the main structural protein of most hard and soft tissues in animals and the human body, which plays an important role in maintaining the biological and structural integrity of the extracellular matrix (ECM) and provides physical support to tissues. Collagen can be extracted and purified from a variety of sources and offers low immunogenicity, a porous structure, good permeability, biocompatibility and biodegradability. Collagen scaffolds have been widely used in tissue engineering due to these excellent properties. However, the poor mechanical property of collagen scaffolds limits their applications to some extent. To overcome this shortcoming, collagen scaffolds can be cross-linked by chemical or physical methods or modified with natural/synthetic polymers or inorganic materials. Biochemical factors can also be introduced to the scaffold to further improve its biological activity. This review will summarize the structure and biological characteristics of collagen and introduce the preparation methods and modification strategies of collagen scaffolds. The typical application of a collagen scaffold in tissue engineering (including nerve, bone, cartilage, tendon, ligament, blood vessel and skin) will be further provided. The prospects and challenges about their future research and application will also be pointed out.