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      Impact of Blockchain-Digital Twin Technology on Precision Health, Pharmaceutical Industry, and Life Sciences: Conference Proceedings, Conv2X 2023

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          Abstract

          The convergence of Digital Twin technologies with precision health, the pharmaceutical industry, and life sciences has garnered substantial recent attention. As we advance toward personalized medicine and precision health, the fusion of Digital Twin and blockchain technologies is poised to enhance healthcare outcomes fundamentally. This conference discussion highlighted pivotal drivers accelerating the adoption of Digital Twin-enabled blockchain solutions, encompassing the shift to a decentralized World Wide Web (Web 3.0), the establishment of a global interconnected health ecosystem, and the distinct advantages offered by converging frontier technologies in optimizing healthcare, pharmaceutical industry, and life sciences. Yet, the effective deployment of blockchain-powered Digital Twins in precision health necessitates robust cyber safety measures, proactive ethical frameworks, data validation, provenance assurance, streamlined supply chain management, and heightened interoperability. These proceedings underscored blockchain-powered Digital Twins’ pivotal role in reshaping health data management, security, sharing, ownership, and monetization and in revolutionizing pharmaceutical supply chain management and novel drugs and therapeutics development within the precision health domain.

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          Internet of Things (IoT)—blockchain-enabled pharmaceutical supply chain resilience in the post-pandemic era

          Xiaohong Chen, Caicai He, Yan Chen … (2022)
          During the COVID-19 pandemic, the current operating environment of pharmaceutical supply chain (PSC) has rapidly changed and faced increasing risks of disruption. The Internet of Things (IoT) and blockchain not only help enhance the efficiency of PSC operations in the information technology domain but also address complex related issues and improve the visibility, flexibility, and transparency of these operations. Although IoT and blockchain have been widely examined in the areas of supply chain and logistics management, further work on PSC is expected by the public to enhance its resilience. To respond to this call, this paper combines a literature review with semi-structured interviews to investigate the characteristics of PSC, the key aspects affecting PSC, and the challenges faced by PSC in the post-pandemic era. An IoT—blockchain-integrated hospital-side oriented PSC management model is also developed. This paper highlights how IoT and blockchain technology can enhance supply chain resilience and provides a reference on how PSC members can cope with the associated risks.
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            Digital Twins: The New Frontier for Personalized Medicine?

            Michaela Cellina, Maurizio Cè, Marco Alì … (2023)
            Digital twins are virtual replicas of physical objects or systems. This new technology is increasingly being adopted in industry to improve the monitoring and efficiency of products and organizations. In healthcare, digital human twins (DHTs) represent virtual copies of patients, including tissues, organs, and physiological processes. Their application has the potential to transform patient care in the direction of increasingly personalized data-driven medicine. The use of DHTs can be integrated with digital twins of healthcare institutions to improve organizational management processes and resource allocation. By modeling the complex multi-omics interactions between genetic and environmental factors, DHTs help monitor disease progression and optimize treatment plans. Through digital simulation, DHT models enable the selection of the most appropriate molecular therapy and accurate 3D representation for precision surgical planning, together with augmented reality tools. Furthermore, they allow for the development of tailored early diagnosis protocols and new targeted drugs. Furthermore, digital twins can facilitate medical training and education. By creating virtual anatomy and physiology models, medical students can practice procedures, enhance their skills, and improve their understanding of the human body. Overall, digital twins have immense potential to revolutionize healthcare, improving patient care and outcomes, reducing costs, and enhancing medical research and education. However, challenges such as data security, data quality, and data interoperability must be addressed before the widespread adoption of digital twins in healthcare. We aim to propose a narrative review on this hot topic to provide an overview of the potential applications of digital twins to improve treatment and diagnostics, but also of the challenges related to their development and widespread diffusion.
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              A Review on: Metaverse in Health Care and Pharma

              Athmaja Shetty, Gururaj S Kulkarni, Rakesh Babu SN … (2022)
              The metaverse can be seen as the immersive follow-up to the text-and-picture-based Internet of today, where people stare at a screen, ignoring physical reality. The metaverse offers online experiences that are more immersive and engaging than those of the past, a seamless blending of the physical and digital worlds, by taking advantage of modern technologies like artificial intelligence (AI), augmented reality (AR), virtual reality (VR), and ever-increasing connection (like 5G networks). The metaverse has the potential to influence healthcare because of the convergence of three current main technical trends. (a) telepresence, (b) digital twinning, and (c) blockchain. These three ideas could be used to provide whole new methods of providing treatment, potentially reducing costs, and significantly improving patient outcomes. Finally, while advancements in digital healthcare are to be commended for facilitating easier access to care for a larger spectrum of people, it is crucial to take into account the ethical issues that they raise.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Blockchain Healthc Today
                Journal ID (iso-abbrev): Blockchain Healthc Today
                Journal ID (publisher-id): BHTY
                Title: Blockchain in Healthcare Today
                Publisher: Partners in Digital Health
                ISSN (Electronic): 2573-8240
                Publication date (Electronic): 07 November 2023
                Publication date Collection: 2023
                Volume: 6
                Electronic Location Identifier: 10.30953/bhty.v6.281
                Affiliations
                [1 ]University of Miami, Coral Gables, Florida, USA
                [2 ]The Metaverse Institute, London, UK
                [3 ]Supply Excellence, Innovation and Digital Strategy at MSD, Kenilworth, New Jersey, USA
                Author notes
                [* ]Corresponding Author: Ingrid Vasiliu-Feltes. Email: ivfeltes@ 123456miami.edu
                Author information
                https://orcid.org/0000-0001-7276-354X
                https://orcid.org/0009-0009-5717-3416
                https://orcid.org/0009-0008-3462-3245
                Article
                Publisher ID: 281
                DOI: 10.30953/bhty.v6.281
                PMC ID: 10770801
                PubMed ID: 38187956
                SO-VID: a16ee5de-de83-4cca-a580-d885f179d867
                Copyright © © 2023 The Authors.
                License:

                This is an open access article distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, adapt, enhance this work noncommercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

                History
                Date received : 04 September 2023
                Date accepted : 17 October 2023
                Funding
                Funding Statement No funding was received.
                Categories
                Subject: Narrative/Systematic Reviews/Meta-Analysis

                Keywords: blockchain,clinical trials,cybersecurity,digital twins,ethics,healthcare,outcomes,pharmaceutical industry,supply chain
                Data availability:
                Keywords: blockchain, clinical trials, cybersecurity, digital twins, ethics, healthcare, outcomes, pharmaceutical industry, supply chain

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