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      Toxic Metal Implications on Agricultural Soils, Plants, Animals, Aquatic life and Human Health

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          Abstract

          The problem of environmental pollution is a global concern as it affects the entire ecosystem. There is a cyclic revolution of pollutants from industrial waste or anthropogenic sources into the environment, farmlands, plants, livestock and subsequently humans through the food chain. Most of the toxic metal cases in Africa and other developing nations are a result of industrialization coupled with poor effluent disposal and management. Due to widespread mining activities in South Africa, pollution is a common site with devastating consequences on the health of animals and humans likewise. In recent years, talks on toxic metal pollution had taken center stage in most scientific symposiums as a serious health concern. Very high levels of toxic metals have been reported in most parts of South African soils, plants, animals and water bodies due to pollution. Toxic metals such as Zinc (Zn), Lead (Pb), Aluminium (Al), Cadmium (Cd), Nickel (Ni), Iron (Fe), Manganese (Mn) and Arsenic (As) are major mining effluents from tailings which contaminate both the surface and underground water, soil and food, thus affecting biological function, endocrine systems and growth. Environmental toxicity in livestock is traceable to pesticides, agrochemicals and toxic metals. In this review, concerted efforts were made to condense the information contained in literature regarding toxic metal pollution and its implications in soil, water, plants, animals, marine life and human health.

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          Most cited references175

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          Pathophysiology of acute kidney injury.

          Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated with high mortality rates. The primary causes of AKI include ischemia, hypoxia, or nephrotoxicity. An underlying feature is a rapid decline in glomerular filtration rate (GFR) usually associated with decreases in renal blood flow. Inflammation represents an important additional component of AKI leading to the extension phase of injury, which may be associated with insensitivity to vasodilator therapy. It is suggested that targeting the extension phase represents an area potential of treatment with the greatest possible impact. The underlying basis of renal injury appears to be impaired energetics of the highly metabolically active nephron segments (i.e., proximal tubules and thick ascending limb) in the renal outer medulla, which can trigger conversion from transient hypoxia to intrinsic renal failure. Injury to kidney cells can be lethal or sublethal. Sublethal injury represents an important component in AKI, as it may profoundly influence GFR and renal blood flow. The nature of the recovery response is mediated by the degree to which sublethal cells can restore normal function and promote regeneration. The successful recovery from AKI depends on the degree to which these repair processes ensue and these may be compromised in elderly or chronic kidney disease (CKD) patients. Recent data suggest that AKI represents a potential link to CKD in surviving patients. Finally, earlier diagnosis of AKI represents an important area in treating patients with AKI that has spawned increased awareness of the potential that biomarkers of AKI may play in the future. © 2012 American Physiological Society. Compr Physiol 2:1303-1353, 2012.
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            Accumulators and excluders ‐strategies in the response of plants to heavy metals

            A Baker (2008)
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              Microbial resistance to metals in the environment.

              Many microorganisms demonstrate resistance to metals in water, soil and industrial waste. Genes located on chromosomes, plasmids, or transposons encode specific resistance to a variety of metal ions. Some metals, such as cobalt, copper, nickel, serve as micronutrients and are used for redox processes, to stabilize molecules through electrostatic interactions, as components of various enzymes, and for regulation of osmotic pressure. Most metals are nonessential, have no nutrient value, and are potentially toxic to microorganisms. These toxic metals interact with essential cellular components through covalent and ionic bonding. At high levels, both essential and nonessential metals can damage cell membranes, alter enzyme specificity, disrupt cellular functions, and damage the structure of DNA. Microorganisms have adapted to the presence of both nutrient and nonessential metals by developing a variety of resistance mechanisms. Six metal resistance mechanisms exist: exclusion by permeability barrier, intra- and extra-cellular sequestration, active transport efflux pumps, enzymatic detoxification, and reduction in the sensitivity of cellular targets to metal ions. The understanding of how microorganisms resist metals can provide insight into strategies for their detoxification or removal from the environment. Copyright 2000 Academic Press.
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                Author and article information

                Journal
                Int J Environ Res Public Health
                Int J Environ Res Public Health
                ijerph
                International Journal of Environmental Research and Public Health
                MDPI
                1661-7827
                1660-4601
                25 March 2020
                April 2020
                : 17
                : 7
                : 2204
                Affiliations
                [1 ]Department of Metallurgy, School of Mining, Metallurgy and Chemical Engineering, Faculty of Engineering and the Built Environment, University of Johannesburg, Auckland Park 2006, South Africa; emakhatha@ 123456uj.ac.za
                [2 ]Department of Chemical Engineering, School of Mining, Metallurgy and Chemical Engineering, Faculty of Engineering and the Built Environment, University of Johannesburg, Auckland Park 2006, South Africa; lukhanyom@ 123456uj.ac.za
                [3 ]Department of Biotechnology & Food Technology, Faculty of Science, University of Johannesburg, Auckland Park 2006, South Africa; nucheokereafor@ 123456gmail.com (N.U.-O.); tendanisebola@ 123456rocketmail.com (T.S.)
                [4 ]South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Medicine and Health Sciences, Stellenbosch University, Stellenbosch 7600, South Africa; vuyom@ 123456sun.ac.za
                Author notes
                [* ]Correspondence: guokereafor@ 123456gmail.com ; Tel.: +27-7475-16904
                Author information
                https://orcid.org/0000-0001-5541-2449
                https://orcid.org/0000-0003-3069-4624
                https://orcid.org/0000-0003-4672-6176
                Article
                ijerph-17-02204
                10.3390/ijerph17072204
                7178168
                32218329
                a15acc83-4043-4fa9-8c21-efb47ff2230c
                © 2020 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 12 February 2020
                : 15 March 2020
                Categories
                Review

                Public health
                toxic metals,contamination,toxicity,human health
                Public health
                toxic metals, contamination, toxicity, human health

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