Tracking inter-institutional spread of NDM and identification of a novel NDM-positive plasmid, pSg1-NDM, using next-generation sequencing approaches.

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Abstract

Owing to gene transposition and plasmid conjugation, New Delhi metallo-β-lactamase (NDM) is typically identified among varied Enterobacteriaceae species and STs. We used WGS to characterize the chromosomal and plasmid molecular epidemiology of NDM transmission involving four institutions in Singapore.

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Journal

Journal ID (iso-abbrev): J. Antimicrob. Chemother.

Title: The Journal of antimicrobial chemotherapy

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1460-2091

ISSN (Print): 0305-7453

Publication date (Electronic): Nov 2016

Volume: 71

Issue: 11

Affiliations

[1 ] Institute of Infectious Disease and Epidemiology, Communicable Disease Centre, 11 Jalan Tan Tock Seng, 308433, Singapore.

[2 ] Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd 119228, NUHS Tower Block, Level 11, 117597, Singapore.

[3 ] National University Hospital, 5 Lower Kent Ridge Rd, 119074, Singapore.

[4 ] Singapore Centre on Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore.

[5 ] NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Centre for Life Sciences (CeLS), #05-01Medical Drive, 117456, Singapore.

[6 ] Centre for Infectious Disease Epidemiology and Research, Saw Swee Hock School of Public Health, National University of Singapore, 12 Science Drive 2, #10-01, 117549, Singapore.

[7 ] Singapore General Hospital, Outram Road, 169608, Singapore.

[8 ] Ng Teng Fong General Hospital, 1 Jurong East Street 21, 609606, Singapore.

[9 ] Khoo Teck Puat Hospital, 90 Yishun Central, 768828, Singapore.

[10 ] Mount Elizabeth Hospital, 3 Mount Elizabeth, 228510, Singapore.

[11 ] Changi General Hospital, 2 Simei Street 3, 529889, Singapore.

[12 ] National Public Health Laboratory, College of Medicine Building, 16 College Road, 169854, Singapore.

[13 ] Singapore Polytechnic, 500 Dover Road, 139651, Singapore.

[14 ] Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore.

[15 ] Pacbio Singapore Pte Ltd, 8 Boon Lay Way, 609964, Singapore.

[16 ] Division of Microbiology, 1829 Ranchlands Blvd NW, Calgary, AB T3G 2A7, Canada.

[17 ] Departments of Pathology and Laboratory Medicine, Microbiology Immunology and Infectious Diseases, University of Calgary, 2500 University Dr NW, Calgary, AB T2N 1N4, Canada.

[18 ] Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa.

[19 ] Department of Statistics & Applied Probability, Block S16, Level 7, 6 Science Drive 2, Faculty of Science, National University of Singapore, 117546, Singapore.

[20 ] Life Sciences Institute, National University of Singapore, Centre for Life 42 Sciences, #05-02, 28 Medical Drive, 117456, Singapore.

[21 ] Genome Institute of Singapore, 60 Biopolis St, #02-01, 138672, Singapore.

[22 ] Institute of Infectious Disease and Epidemiology, Communicable Disease Centre, 11 Jalan Tan Tock Seng, 308433, Singapore oon_tek_ng@ttsh.com.sg.

Article

Publisher Item ID: dkw277

DOI: 10.1093/jac/dkw277

PubMed ID: 27494913

SO-VID: a02485b6-aa64-4fe2-8f90-e196b8b40f7b

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