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Abstract

Treatment with intralesional triamcinolone/betamethasone is recommended for infantile sight-threatening periocular haemangiomas. This study investigates the endocrine and weight changes in 15 infants undergoing therapy over 12 years. 15 infants, median age 19 weeks (range 10-56) receiving intra/perilesional triamcinolone/betamethasone underwent serial measurement of weight, early morning serum cortisol and adrenocorticotropic hormone (ACTH) before and after injection. Cortisol fell from a median (range) of 383 (112-594) to 28 (<10-506) nmol/l (p=0.005) and ACTH from 26 (14-134) to 9 (5-20) ng/l (p=0.05) from before injection to 4 weeks after treatment. Prolonged adrenal suppression occurred in 13 out of 15 cases with time to recovery being 19.5 (4-65) weeks. Failure to gain weight appropriately was observed in 14 infants but recovered once normal adrenal function was re-established. Prolonged adrenal suppression following triamcinolone/betamethasone injection for periocular haemangiomas is common and associated with faltering weight gain.

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PubMed ID:: 21321258

DOI:: 10.1136/adc.2010.204859

ScienceOpen disciplines: Chemistry

Keywords: Adrenal Insufficiency,blood,chemically induced,Adrenocorticotropic Hormone,Betamethasone,administration & dosage,adverse effects,Child, Preschool,Drug Combinations,Eyelid Neoplasms,drug therapy,Female,Glucocorticoids,Hemangioma,Humans,Hydrocortisone,Infant,Injections, Intralesional,Male,Retrospective Studies,Triamcinolone,Weight Gain,drug effects

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ScienceOpen disciplines: Chemistry

Keywords: Adrenal Insufficiency, blood, chemically induced, Adrenocorticotropic Hormone, Betamethasone, administration & dosage, adverse effects, Child, Preschool, Drug Combinations, Eyelid Neoplasms, drug therapy, Female, Glucocorticoids, Hemangioma, Humans, Hydrocortisone, Infant, Injections, Intralesional, Male, Retrospective Studies, Triamcinolone, Weight Gain, drug effects

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