Potential for pharmacokinetic interactions between Schisandra sphenanthera and bosutinib, but not imatinib: in vitro metabolism study combined with a physiologically-based pharmacokinetic modelling approach.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

This study aimed to investigate the potential interaction between Schisandra sphenanthera, imatinib and bosutinib combining in vitro and in silico methods.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Br J Clin Pharmacol

Title: British journal of clinical pharmacology

Publisher: Wiley

ISSN (Electronic): 1365-2125

ISSN (Print): 0306-5251

Publication date (Electronic): Oct 2020

Volume: 86

Issue: 10

Affiliations

[1 ] Sydney Pharmacy School, The University of Sydney, Sydney, NSW, Australia.

[2 ] School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia.

[3 ] University of South Australia Cancer Research Institute, University of South Australia, Adelaide, SA, Australia.

Article

DOI: 10.1111/bcp.14303

PMC ID: 7495297

PubMed ID: 32250458

SO-VID: 9de5a049-220a-45b8-b900-b136455e7879

History

Keywords: modelling and simulation,herb-drug interactions,physiologically-based pharmacokinetic (PBPK),drug metabolism

Data availability:

Keywords: modelling and simulation, herb-drug interactions, physiologically-based pharmacokinetic (PBPK), drug metabolism

Potential for pharmacokinetic interactions between Schisandra sphenanthera and bosutinib, but not imatinib: in vitro metabolism study combined with a physiologically-based pharmacokinetic modelling approach.

Read this article at

Abstract

Related collections

Network and Systems Medicine

Author and article information

Journal

Affiliations

Article

History

Comments

Comment on this article

Cited by 2