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A serological assay to detect SARS-CoV-2 seroconversion in humans
Fatima Amanat ,
Daniel Stadlbauer ,
Shirin Strohmeier ,
Thi H. O. Nguyen ,
Veronika Chromikova ,
Meagan McMahon ,
Kaijun Jiang ,
Guha Asthagiri Arunkumar ,
Denise Jurczyszak ,
Jose Polanco ,
Maria Bermudez-Gonzalez ,
Giulio Kleiner ,
Teresa Aydillo ,
Lisa Miorin ,
Daniel S. Fierer ,
Luz Amarilis Lugo ,
Erna Milunka Kojic ,
Jonathan Stoever ,
Sean T. H. Liu ,
Charlotte Cunningham-Rundles ,
Philip L. Felgner ,
Thomas Moran ,
Adolfo García-Sastre ,
Daniel Caplivski ,
Allen C. Cheng ,
Katherine Kedzierska ,
Olli Vapalahti ,
Jussi M. Hepojoki ,
Viviana Simon ,
Florian Krammer
May 12 2020
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Abstract
<p class="first" id="d36246427e491">Here, we describe a serological enzyme-linked
immunosorbent assay for the screening
and identification of human SARS-CoV-2 seroconverters. This assay does not require
the handling of infectious virus, can be adjusted to detect different antibody types
in serum and plasma and is amenable to scaling. Serological assays are of critical
importance to help define previous exposure to SARS-CoV-2 in populations, identify
highly reactive human donors for convalescent plasma therapy and investigate correlates
of protection.
</p>