铁死亡的分子机制及其对膀胱癌的影响 Translated title: Molecular mechanisms of ferroptosis and its effects on bladder cancer

Abstract

膀胱癌(bladder cancer，BC)是泌尿系统三大常见恶性肿瘤之一，具有发病率高、易转移、治疗效果不佳、预后较差的特点，严重威胁着全人类的健康。肿瘤细胞表现出强烈的需铁现象，而铁超载会诱导细胞发生铁死亡，即一种由脂质过氧化和细胞膜损伤引起的铁依赖性细胞死亡。因此，铁死亡具有很强的抗肿瘤潜力。铁死亡的分子机制与细胞磷脂代谢异常、铁代谢异常、抗氧化和非抗氧化系统Xc ^-/谷胱甘肽(glutathione，GSH)/谷胱甘肽过氧化物酶4(glutathione peroxidase 4，GPX4)的失调有关。铁死亡相关分子在BC的发生和发展、转移、耐药及免疫反应等方面发挥着重要的作用，有望成为治疗BC的靶点。

Translated abstract

Bladder cancer (BC) is one of the 3 common malignant tumors in the urinary system, with high incidence, easy metastasis, poor therapeutic efficacy, and poor prognosis, which seriously threatens the health of human. Tumor cells exhibit a strong demand for iron, and iron overload can induce ferroptosis, which is an iron dependent cell death caused by lipid peroxidation and cell membrane damage. Therefore, ferroptosis has strong anti-tumor potential. The molecular mechanisms of ferroptosis is associated with abnormalities in cellular phospholipid metabolism and iron metabolism, and dysregulation of antioxidant and non-antioxidant systems Xc ^-/glutathione (GSH)/glutathione peroxidase 4 (GPX4). Ferroptosis relevant molecules play important roles in the occurrence and development, metastasis, drug resistance, and immune response of BC, and are expected to become targets for the treatment of BC.