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      Vickybot, a Chatbot for Anxiety-Depressive Symptoms and Work-Related Burnout in Primary Care and Health Care Professionals: Development, Feasibility, and Potential Effectiveness Studies

      research-article
      , MD 1 , 2 , 3 , 4 , 5 , , PsyD, PhD 1 , 2 , 3 , 4 , 5 , , PsyD 1 , , PsyD 1 , , MD, PhD 1 , 2 , 3 , 4 , 5 , , PsyD 1 , 2 , 4 , , MD, PhD 1 , 2 , 3 , 4 , 5 , , RNC 1 , 2 , , PsyD 1 , 2 , 3 , 4 , 5 , , PsyD 1 , , PsyD 1 , , PsyD 1 , , PsyD 1 , , PsyD, PhD 1 , , PsyD 1 , , PsyD 1 , , PsyD 1 , , PsyD 1 , , PsyD 1 , , PsyD 1 , , MSc, PhD 3 , 6 , , MD, PhD 3 , 6 , 7 , 8 , , MD 9 , , MD 9 , , MD 10 , , MD, PhD 10 , , MD, PhD 11 , , MD, PhD 12 , , MD, PhD 1 , 2 , 3 , 4 , 13 , , MSc, PsyD 1 , 14 , 15 , , MD, PhD 1 , 14 , 15 , , PsyD, PhD 1 , , MD 16 , , PsyD 16 , , RNC 16 , , PsyD, PhD 1 , 2 , 3 , 4 , 5 , , PsyD, PhD 1 , 2 , 3 , 4 , 5 , , PsyD, PhD 1 , 2 , 3 , 4 , 5 , , PsyD, PhD 1 , 2 , 3 , 4 , 5 , , MD, PhD 1 , 2 , 3 , 4 , 5 , , MD, PhD 1 , 2 , 3 , 4 , 5 , , MD 1 , 2 , 3 , 4 , 5 , , MD 1 , 2 , 3 , 4 , 5 , , MD 1 , 2 , 3 , 4 , 5 , , PsyD, PhD 1 , 2 , 3 , 4 , 5 , , MSc 17 , , MSc 17 , , MSc, PhD 17 , , MD, PhD 1 , 2 , 3 , 4 , 5 , , MD, PhD 1 , 2 , 3 , 4 , 5 ,
      (Reviewer), (Reviewer)
      Journal of Medical Internet Research
      JMIR Publications
      primary care, health care workers, depression, anxiety, symptom, burnout, digital, smartphone, chatbot, primary care digital support tool in mental health, PRESTO

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          Abstract

          Background

          Many people attending primary care (PC) have anxiety-depressive symptoms and work-related burnout compounded by a lack of resources to meet their needs. The COVID-19 pandemic has exacerbated this problem, and digital tools have been proposed as a solution.

          Objective

          We aimed to present the development, feasibility, and potential effectiveness of Vickybot, a chatbot aimed at screening, monitoring, and reducing anxiety-depressive symptoms and work-related burnout, and detecting suicide risk in patients from PC and health care workers.

          Methods

          Healthy controls (HCs) tested Vickybot for reliability. For the simulation study, HCs used Vickybot for 2 weeks to simulate different clinical situations. For feasibility and effectiveness study, people consulting PC or health care workers with mental health problems used Vickybot for 1 month. Self-assessments for anxiety (Generalized Anxiety Disorder 7-item) and depression (Patient Health Questionnaire-9) symptoms and work-related burnout (based on the Maslach Burnout Inventory) were administered at baseline and every 2 weeks. Feasibility was determined from both subjective and objective user-engagement indicators (UEIs). Potential effectiveness was measured using paired 2-tailed t tests or Wilcoxon signed-rank test for changes in self-assessment scores.

          Results

          Overall, 40 HCs tested Vickybot simultaneously, and the data were reliably transmitted and registered. For simulation, 17 HCs (n=13, 76% female; mean age 36.5, SD 9.7 years) received 98.8% of the expected modules. Suicidal alerts were received correctly. For the feasibility and potential effectiveness study, 34 patients (15 from PC and 19 health care workers; 76% [26/34] female; mean age 35.3, SD 10.1 years) completed the first self-assessments, with 100% (34/34) presenting anxiety symptoms, 94% (32/34) depressive symptoms, and 65% (22/34) work-related burnout. In addition, 27% (9/34) of patients completed the second self-assessment after 2 weeks of use. No significant differences were found between the first and second self-assessments for anxiety ( t 8=1.000; P=.34) or depressive ( t 8=0.40; P=.70) symptoms. However, work-related burnout scores were moderately reduced ( z=−2.07, P=.04, r=0.32). There was a nonsignificant trend toward a greater reduction in anxiety-depressive symptoms and work-related burnout with greater use of the chatbot. Furthermore, 9% (3/34) of patients activated the suicide alert, and the research team promptly intervened with successful outcomes. Vickybot showed high subjective UEI (acceptability, usability, and satisfaction), but low objective UEI (completion, adherence, compliance, and engagement). Vickybot was moderately feasible.

          Conclusions

          The chatbot was useful in screening for the presence and severity of anxiety and depressive symptoms, and for detecting suicidal risk. Potential effectiveness was shown to reduce work-related burnout but not anxiety or depressive symptoms. Subjective perceptions of use contrasted with low objective-use metrics. Our results are promising but suggest the need to adapt and enhance the smartphone-based solution to improve engagement. A consensus on how to report UEIs and validate digital solutions, particularly for chatbots, is required.

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          A brief measure for assessing generalized anxiety disorder: the GAD-7.

          Generalized anxiety disorder (GAD) is one of the most common mental disorders; however, there is no brief clinical measure for assessing GAD. The objective of this study was to develop a brief self-report scale to identify probable cases of GAD and evaluate its reliability and validity. A criterion-standard study was performed in 15 primary care clinics in the United States from November 2004 through June 2005. Of a total of 2740 adult patients completing a study questionnaire, 965 patients had a telephone interview with a mental health professional within 1 week. For criterion and construct validity, GAD self-report scale diagnoses were compared with independent diagnoses made by mental health professionals; functional status measures; disability days; and health care use. A 7-item anxiety scale (GAD-7) had good reliability, as well as criterion, construct, factorial, and procedural validity. A cut point was identified that optimized sensitivity (89%) and specificity (82%). Increasing scores on the scale were strongly associated with multiple domains of functional impairment (all 6 Medical Outcomes Study Short-Form General Health Survey scales and disability days). Although GAD and depression symptoms frequently co-occurred, factor analysis confirmed them as distinct dimensions. Moreover, GAD and depression symptoms had differing but independent effects on functional impairment and disability. There was good agreement between self-report and interviewer-administered versions of the scale. The GAD-7 is a valid and efficient tool for screening for GAD and assessing its severity in clinical practice and research.
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            The PHQ-9: validity of a brief depression severity measure.

            While considerable attention has focused on improving the detection of depression, assessment of severity is also important in guiding treatment decisions. Therefore, we examined the validity of a brief, new measure of depression severity. The Patient Health Questionnaire (PHQ) is a self-administered version of the PRIME-MD diagnostic instrument for common mental disorders. The PHQ-9 is the depression module, which scores each of the 9 DSM-IV criteria as "0" (not at all) to "3" (nearly every day). The PHQ-9 was completed by 6,000 patients in 8 primary care clinics and 7 obstetrics-gynecology clinics. Construct validity was assessed using the 20-item Short-Form General Health Survey, self-reported sick days and clinic visits, and symptom-related difficulty. Criterion validity was assessed against an independent structured mental health professional (MHP) interview in a sample of 580 patients. As PHQ-9 depression severity increased, there was a substantial decrease in functional status on all 6 SF-20 subscales. Also, symptom-related difficulty, sick days, and health care utilization increased. Using the MHP reinterview as the criterion standard, a PHQ-9 score > or =10 had a sensitivity of 88% and a specificity of 88% for major depression. PHQ-9 scores of 5, 10, 15, and 20 represented mild, moderate, moderately severe, and severe depression, respectively. Results were similar in the primary care and obstetrics-gynecology samples. In addition to making criteria-based diagnoses of depressive disorders, the PHQ-9 is also a reliable and valid measure of depression severity. These characteristics plus its brevity make the PHQ-9 a useful clinical and research tool.
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              Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019

              Key Points Question What factors are associated with mental health outcomes among health care workers in China who are treating patients with coronavirus disease 2019 (COVID-19)? Findings In this cross-sectional study of 1257 health care workers in 34 hospitals equipped with fever clinics or wards for patients with COVID-19 in multiple regions of China, a considerable proportion of health care workers reported experiencing symptoms of depression, anxiety, insomnia, and distress, especially women, nurses, those in Wuhan, and front-line health care workers directly engaged in diagnosing, treating, or providing nursing care to patients with suspected or confirmed COVID-19. Meaning These findings suggest that, among Chinese health care workers exposed to COVID-19, women, nurses, those in Wuhan, and front-line health care workers have a high risk of developing unfavorable mental health outcomes and may need psychological support or interventions.
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                Author and article information

                Contributors
                Journal
                J Med Internet Res
                J Med Internet Res
                JMIR
                Journal of Medical Internet Research
                JMIR Publications (Toronto, Canada )
                1439-4456
                1438-8871
                2023
                3 April 2023
                : 25
                : e43293
                Affiliations
                [1 ] Department of Psychiatry and Psychology Institute of Neuroscience Hospital Clínic de Barcelona Barcelona Spain
                [2 ] Bipolar and Depressive Disorders Unit Digital Innovation Group Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Barcelona Spain
                [3 ] Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM) Instituto de Salud Carlos III Madrid Spain
                [4 ] Department of Medicine School of Medicine and Health Sciences University of Barcelona (UB) Barcelona Spain
                [5 ] Institute of Neurosciences (UBNeuro) Barcelona Spain
                [6 ] Imaging of Mood- and Anxiety-Related Disorders group (IMARD) Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Barcelona Spain
                [7 ] Early Psychosis: Interventions & Clinical-detection (EPIC) Lab, Department of Psychosis Studies Institute of Psychiatry Psychology and Neuroscience King's College London London United Kingdom
                [8 ] Center for Psychiatry Research Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden
                [9 ] CAP Casanova, Consorci d'Atenció Primaria de Salut Barcelona Esquerra (CAPSBE) Barcelona Spain
                [10 ] CAP Borrell, Consorci d'Atenció Primaria de Salut Barcelona Esquerra (CAPSBE) Barcelona Spain
                [11 ] Centre for Affective Disorders Institute of Psychiatry, Psychology & Neuroscience King's College London London United Kingdom
                [12 ] Abi Global Health Dublin Ireland
                [13 ] European Association of Psychosomatic Medicine Oregon, OR United States
                [14 ] Grup de Recerca en Addicions Clínic Department of Psychiatry Addiction Unit Hospital Clínic of Barcelona Barcelona Spain
                [15 ] Red de Investigación en Atención Primaria de Adicciones (RIAPAD) Barcelona Spain
                [16 ] Occupational Health Department, Hospital Clínic de Barcelona Barcelona Spain
                [17 ] Barcelona Supercomputing Center (BSC) Text Mining Technologies in the Health Domain Barcelona Spain
                Author notes
                Corresponding Author: Diego Hidalgo-Mazzei dahidalg@ 123456clinic.cat
                Author information
                https://orcid.org/0000-0002-6798-4054
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                https://orcid.org/0000-0002-9029-8933
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                https://orcid.org/0000-0003-1489-6760
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                https://orcid.org/0000-0001-5550-8272
                https://orcid.org/0000-0002-1818-4974
                https://orcid.org/0000-0002-3538-0838
                https://orcid.org/0000-0002-2491-200X
                https://orcid.org/0000-0003-1240-5438
                https://orcid.org/0000-0002-7098-5146
                https://orcid.org/0000-0002-0767-1507
                https://orcid.org/0000-0003-1072-4435
                https://orcid.org/0000-0002-1394-4508
                https://orcid.org/0000-0003-2291-6952
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                https://orcid.org/0000-0003-2597-8454
                https://orcid.org/0000-0003-4361-6422
                https://orcid.org/0000-0002-3850-8374
                https://orcid.org/0000-0001-8104-5291
                https://orcid.org/0000-0002-2015-4678
                https://orcid.org/0000-0003-1089-4047
                https://orcid.org/0009-0004-9091-2624
                https://orcid.org/0000-0003-1673-8248
                https://orcid.org/0000-0003-0335-582X
                https://orcid.org/0000-0002-0623-6263
                https://orcid.org/0000-0002-4787-2557
                https://orcid.org/0000-0002-6999-7510
                https://orcid.org/0000-0001-6320-4420
                https://orcid.org/0000-0003-1785-7126
                https://orcid.org/0000-0003-3503-8626
                https://orcid.org/0000-0002-5961-6032
                https://orcid.org/0000-0001-6017-2734
                https://orcid.org/0000-0002-3531-8620
                https://orcid.org/0000-0001-7855-2946
                https://orcid.org/0000-0003-0711-0029
                https://orcid.org/0000-0002-0548-0053
                https://orcid.org/0000-0002-2693-6849
                Article
                v25i1e43293
                10.2196/43293
                10131622
                36719325
                97cc959b-a871-43ca-b604-548884c1149b
                ©Gerard Anmella, Miriam Sanabra, Mireia Primé-Tous, Xavier Segú, Myriam Cavero, Ivette Morilla, Iria Grande, Victoria Ruiz, Ariadna Mas, Inés Martín-Villalba, Alejandro Caballo, Julia-Parisad Esteva, Arturo Rodríguez-Rey, Flavia Piazza, Francisco José Valdesoiro, Claudia Rodriguez-Torrella, Marta Espinosa, Giulia Virgili, Carlota Sorroche, Alicia Ruiz, Aleix Solanes, Joaquim Radua, María Antonieta Also, Elisenda Sant, Sandra Murgui, Mireia Sans-Corrales, Allan H Young, Victor Vicens, Jordi Blanch, Elsa Caballeria, Hugo López-Pelayo, Clara López, Victoria Olivé, Laura Pujol, Sebastiana Quesada, Brisa Solé, Carla Torrent, Anabel Martínez-Aran, Joana Guarch, Ricard Navinés, Andrea Murru, Giovanna Fico, Michele de Prisco, Vicenzo Oliva, Silvia Amoretti, Casimiro Pio-Carrino, María Fernández-Canseco, Marta Villegas, Eduard Vieta, Diego Hidalgo-Mazzei. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 03.04.2023.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.

                History
                : 7 October 2022
                : 8 December 2022
                : 19 December 2022
                : 31 January 2023
                Categories
                Original Paper
                Original Paper

                Medicine
                primary care,health care workers,depression,anxiety,symptom,burnout,digital,smartphone,chatbot,primary care digital support tool in mental health,presto

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