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      Contact Lens Materials: A Materials Science Perspective

      review-article
      1 , 1 , 2 , *
      Materials
      MDPI
      contact lens, materials, biomedical implant

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          Abstract

          More is demanded from ophthalmic treatments using contact lenses, which are currently used by over 125 million people around the world. Improving the material of contact lenses (CLs) is a now rapidly evolving discipline. These materials are developing alongside the advances made in related biomaterials for applications such as drug delivery. Contact lens materials are typically based on polymer- or silicone-hydrogel, with additional manufacturing technologies employed to produce the final lens. These processes are simply not enough to meet the increasing demands from CLs and the ever-increasing number of contact lens (CL) users. This review provides an advanced perspective on contact lens materials, with an emphasis on materials science employed in developing new CLs. The future trends for CL materials are to graft, incapsulate, or modify the classic CL material structure to provide new or improved functionality. In this paper, we discuss some of the fundamental material properties, present an outlook from related emerging biomaterials, and provide viewpoints of precision manufacturing in CL development.

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          Most cited references210

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          Scaffolds for Bone Tissue Engineering: State of the art and new perspectives.

          This review is intended to give a state of the art description of scaffold-based strategies utilized in Bone Tissue Engineering. Numerous scaffolds have been tested in the orthopedic field with the aim of improving cell viability, attachment, proliferation and homing, osteogenic differentiation, vascularization, host integration and load bearing. The main traits that characterize a scaffold suitable for bone regeneration concerning its biological requirements, structural features, composition, and types of fabrication are described in detail. Attention is then focused on conventional and Rapid Prototyping scaffold manufacturing techniques. Conventional manufacturing approaches are subtractive methods where parts of the material are removed from an initial block to achieve the desired shape. Rapid Prototyping techniques, introduced to overcome standard techniques limitations, are additive fabrication processes that manufacture the final three-dimensional object via deposition of overlying layers. An important improvement is the possibility to create custom-made products by means of computer assisted technologies, starting from patient's medical images. As a conclusion, it is highlighted that, despite its encouraging results, the clinical approach of Bone Tissue Engineering has not taken place on a large scale yet, due to the need of more in depth studies, its high manufacturing costs and the difficulty to obtain regulatory approval. PUBMED search terms utilized to write this review were: "Bone Tissue Engineering", "regenerative medicine", "bioactive scaffolds", "biomimetic scaffolds", "3D printing", "3D bioprinting", "vascularization" and "dentistry".
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            Surface hydration: Principles and applications toward low-fouling/nonfouling biomaterials

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              Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics

              Wearable contact lenses which can monitor physiological parameters have attracted substantial interests due to the capability of direct detection of biomarkers contained in body fluids. However, previously reported contact lens sensors can only monitor a single analyte at a time. Furthermore, such ocular contact lenses generally obstruct the field of vision of the subject. Here, we developed a multifunctional contact lens sensor that alleviates some of these limitations since it was developed on an actual ocular contact lens. It was also designed to monitor glucose within tears, as well as intraocular pressure using the resistance and capacitance of the electronic device. Furthermore, in-vivo and in-vitro tests using a live rabbit and bovine eyeball demonstrated its reliable operation. Our developed contact lens sensor can measure the glucose level in tear fluid and intraocular pressure simultaneously but yet independently based on different electrical responses.
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                Author and article information

                Journal
                Materials (Basel)
                Materials (Basel)
                materials
                Materials
                MDPI
                1996-1944
                14 January 2019
                January 2019
                : 12
                : 2
                : 261
                Affiliations
                [1 ]Centre of MicroNano Manufacturing Technology (MNMT-Dublin), University College Dublin, D14 YH57 Dublin, Ireland; christopher.musgrave@ 123456ucd.ie
                [2 ]State Key Laboratory of Precision Measuring Technology and Instruments, Centre of MicroNano Manufacturing Technology (MNMT), Tianjin University, Tianjin 300072, China
                Author notes
                [* ]Correspondence: fengzhou.fang@ 123456ucd.ie ; Tel.: +353-1-716-1810
                Author information
                https://orcid.org/0000-0002-8301-447X
                https://orcid.org/0000-0002-8716-5988
                Article
                materials-12-00261
                10.3390/ma12020261
                6356913
                30646633
                97b74d12-16d4-44c6-9614-0ddba1518f53
                © 2019 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 20 December 2018
                : 07 January 2019
                Categories
                Review

                contact lens,materials,biomedical implant
                contact lens, materials, biomedical implant

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