Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma

Choueiri, Toni K.; Tomczak, Piotr; Park, Se Hoon; Venugopal, Balaji; Ferguson, Tom; Symeonides, Stefan N.; Hájek, Jaroslav; Chang, Yen-Hwa; Lee, Jae-Lyun; Sarwar, Naveed; Haas, Naomi B; Gurney, Howard; Sawrycki, Piotr; Mahave, Mauricio; Gross-Goupil, Marine; Zhang, Tian Tian; Burke, John M.; Doshi, Gurjyot K.; Melichar, Bohuslav; Kopyltsov, Evgeniy; Alva, Ajjai Shivaram; Oudard, Stéphane; Topart, Delphine; Hammers, Hans; Kitamura, Hiroshi; McDermott, David F; Silva, Adriano Z.; Winquist, Eric; Cornell, Jerry; Elfiky, Aymen; Burgents, Joseph E; Perini, Rodolfo F.; Powles, Thomas

doi:10.1056/NEJMoa2312695

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Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma

Author(s): Toni K. Choueiri ¹ , Piotr Tomczak ¹ , Se Hoon Park ¹ , Balaji Venugopal ¹ , Tom Ferguson ¹ , Stefan N. Symeonides ¹ , Jaroslav Hajek ¹ , Yen-Hwa Chang ¹ , Jae-Lyun Lee ¹ , Naveed Sarwar ¹ , Naomi B. Haas ¹ , Howard Gurney ¹ , Piotr Sawrycki ¹ , Mauricio Mahave ¹ , Marine Gross-Goupil ¹ , Tian Zhang ¹ , John M. Burke ¹ , Gurjyot Doshi ¹ , Bohuslav Melichar ¹ , Evgeniy Kopyltsov ¹ , Ajjai Alva ¹ , Stephane Oudard ¹ , Delphine Topart ¹ , Hans Hammers ¹ , Hiroshi Kitamura ¹ , David F. McDermott ¹ , Adriano Silva ¹ , Eric Winquist ¹ , Jerry Cornell ¹ , Aymen Elfiky ¹ , Joseph E. Burgents ¹ , Rodolfo F. Perini ¹ , Thomas Powles ¹

Publication date Created: April 18 2024

Publication date (Print): April 18 2024

Journal: New England Journal of Medicine

Publisher: Massachusetts Medical Society

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Most cited references 31

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Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma

Megan Wind-Rotolo, Sergio Bracarda, Howard Gurney … (2018)

Nivolumab plus ipilimumab produced objective responses in patients with advanced renal-cell carcinoma in a pilot study. This phase 3 trial compared nivolumab plus ipilimumab with sunitinib for previously untreated clear-cell advanced renal-cell carcinoma.

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Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma

Brian Rini, Elizabeth R Plimack, Viktor P Stus … (2019)

The combination of pembrolizumab and axitinib showed antitumor activity in a phase 1b trial involving patients with previously untreated advanced renal-cell carcinoma. Whether pembrolizumab plus axitinib would result in better outcomes than sunitinib in such patients was unclear.

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Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma

Robert Motzer, Boris V. Alekseev, Sun-Young Rha … (2021)

Lenvatinib in combination with pembrolizumab or everolimus has activity against advanced renal cell carcinoma. The efficacy of these regimens as compared with that of sunitinib is unclear.

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Author and article information

Journal

Title: New England Journal of Medicine

Abbreviated Title: N Engl J Med

Publisher: Massachusetts Medical Society

ISSN (Print): 0028-4793

ISSN (Electronic): 1533-4406

Publication date Created: April 18 2024

Publication date (Print): April 18 2024

Volume: 390

Issue: 15

Pages: 1359-1371

Affiliations

[1 ]From Dana–Farber Cancer Institute and Harvard Medical School (T.K.C.) and Beth Israel Deaconess Medical Center (D.F.M.) — all in Boston; Poznan University of Medical Sciences, Poznan (P.T.), and Provincial Hospital in Torun, Torun (P.S.) — both in Poland; Samsung Medical Center, Sungkyunkwan University School of Medicine (S.H.P.), and Asan Medical Center, University of Ulsan College of Medicine (J.-L.L.) — both in Seoul, South Korea; Beatson West of Scotland Cancer Centre and the University of...

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DOI: 10.1056/NEJMoa2312695

PubMed ID: 38631003

SO-VID: 96936b21-0b16-4b17-9015-17b54e8e0c84

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