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Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH.
J Gregory Cairncross
1 ,
Meihua Wang ,
Robert B Jenkins ,
Edward G Shaw ,
Caterina Giannini ,
David G Brachman ,
Jan C Buckner ,
Karen L Fink ,
Luis Souhami ,
Normand J Laperriere ,
Jason T Huse ,
Minesh P Mehta ,
Walter J Curran
Mar 10 2014
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Abstract
Patients with 1p/19q codeleted anaplastic oligodendroglial tumors who participated in RTOG (Radiation Therapy Oncology Group) 9402 lived much longer after chemoradiotherapy (CRT) than radiation therapy (RT) alone. However, some patients with noncodeleted tumors also benefited from CRT; survival curves separated after the median had been reached, and significantly more patients lived ≥ 10 years after CRT than RT. Thus, 1p/19q status may not identify all responders to CRT.