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      KeratoDetect: Keratoconus Detection Algorithm Using Convolutional Neural Networks

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      Computational Intelligence and Neuroscience
      Hindawi

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          Abstract

          Keratoconus (KTC) is a noninflammatory disorder characterized by progressive thinning, corneal deformation, and scarring of the cornea. The pathological mechanisms of this condition have been investigated for a long time. In recent years, this disease has come to the attention of many research centers because the number of people diagnosed with keratoconus is on the rise. In this context, solutions that facilitate both the diagnostic and treatment options are quickly needed. The main contribution of this paper is the implementation of an algorithm that is able to determine whether an eye is affected or not by keratoconus. The KeratoDetect algorithm analyzes the corneal topography of the eye using a convolutional neural network (CNN) that is able to extract and learn the features of a keratoconus eye. The results show that the KeratoDetect algorithm ensures a high level of performance, obtaining an accuracy of 99.33% on the data test set. KeratoDetect can assist the ophthalmologist in rapid screening of its patients, thus reducing diagnostic errors and facilitating treatment.

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          An introduction to decision tree modeling

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            Keratoconus: an inflammatory disorder?

            Keratoconus has been classically defined as a progressive, non-inflammatory condition, which produces a thinning and steepening of the cornea. Its pathophysiological mechanisms have been investigated for a long time. Both genetic and environmental factors have been associated with the disease. Recent studies have shown a significant role of proteolytic enzymes, cytokines, and free radicals; therefore, although keratoconus does not meet all the classic criteria for an inflammatory disease, the lack of inflammation has been questioned. The majority of studies in the tears of patients with keratoconus have found increased levels of interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α), and matrix metalloproteinase (MMP)-9. Eye rubbing, a proven risk factor for keratoconus, has been also shown recently to increase the tear levels of MMP-13, IL-6, and TNF-α. In the tear fluid of patients with ocular rosacea, IL-1α and MMP-9 have been reported to be significantly elevated, and cases of inferior corneal thinning, resembling keratoconus, have been reported. We performed a literature review of published biochemical changes in keratoconus that would support that this could be, at least in part, an inflammatory condition.
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              Use of a support vector machine for keratoconus and subclinical keratoconus detection by topographic and tomographic data.

              To define a new classification method for the diagnosis of keratoconus based on corneal measurements provided by a Scheimpflug camera combined with Placido corneal topography (Sirius, CSO, Florence, Italy).
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                Author and article information

                Contributors
                Journal
                Comput Intell Neurosci
                Comput Intell Neurosci
                CIN
                Computational Intelligence and Neuroscience
                Hindawi
                1687-5265
                1687-5273
                2019
                23 January 2019
                : 2019
                : 8162567
                Affiliations
                Computers, Electronics and Automation Department, Stefan cel Mare University of Suceava, Suceava 720229, Romania
                Author notes

                Guest Editor: Vlado Delic

                Author information
                http://orcid.org/0000-0001-7734-4854
                Article
                10.1155/2019/8162567
                6364125
                30809255
                95461086-0e73-4548-8a76-aa52000104c4
                Copyright © 2019 Alexandru Lavric and Popa Valentin.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 25 October 2018
                : 19 November 2018
                : 24 December 2018
                Funding
                Funded by: Romanian Ministry of Research and Innovation
                Award ID: PN-III-P1-1.2-PCCDI-2017-0776
                Award ID: 36 PCCDI/15.03.2018
                Categories
                Research Article

                Neurosciences
                Neurosciences

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