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      Pediatric Pleomorphic Adenoma of the Parotid: Case Report, Review of Literature and Novel Therapeutic Targets

      case-report

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          Abstract

          Salivary gland tumors are extremely rare and encompass a diverse group of histologies. Less than 5% of the affected population is pediatric. We present a case of 6-year-old child with pleomorphic adenoma of the parotid. The patient underwent a superficial parotidectomy. Recurrence was not observed in the six months of follow-up. Surgery is the mainstay of the management of benign salivary gland tumors. Although novel molecular agents are being explored, personalized therapy would be a challenge due to the rarity and vast genetic/histologic variations of salivary gland tumors.

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          Masses of the salivary gland region in children.

          J Maddalozzo, J Lüdemann, Brandon Bentz … (2000)
          Noninflammatory masses of the salivary gland region in children are extremely rare. Therefore, very few published individual and institution-based experiences exist. Retrospective chart review from 1990 through 1997. University-based children's hospital. Patients 18 years of age or younger with a tumor in the salivary gland region. Masses of infectious origin were excluded. Hemangiomas and lymphangiomas were tallied for relative incidences only. Three hundred twenty-four consecutive cases of salivary gland masses were found: 192 hemangiomas (59.2%), 89 lymphangiomas (27.5%), and 43 (13.3%) solid masses. No significant difference was found between the age at presentation of the patients with benign solid tumors and the patients with malignant solid tumors (mean + SEM age, 7.2 + 0.7 years). Sixty-one percent of the masses were found in the parotid region; 18% were localized to the submandibular gland region; and the remaining 21% were located in a minor salivary gland site. The most common benign perisalivary masses were pilomatrixomas (20.9%), followed by pleomorphic adenomas (11.6%). The most common malignant masses were mucoepidermoid carcinomas (9.3%), followed by rhabdomyosarcomas (7.0%). Treatment was individualized to the disease. Twenty-two patients had adequate data for follow-up analysis (mean + SEM follow-up, 30.0 + 8.4 months). Four patients (18.2%) experienced recurrent or residual disease and were alive with disease at last follow-up, and 100% of our population demonstrated disease-specific survival at last follow-up. Vascular lesions outnumber solid tumors of the salivary gland region. The most common salivary tumors were pleomorphic adenomas, followed by mucoepidermoid carcinomas. Although certain solid salivary masses may demonstrate locally aggressive behavior, the overall prognosis is favorable. Arch Otolaryngol Head Neck Surg. 2000;126:1435-1439
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            Primary epithelial salivary gland tumours in children and adolescents

            M. Gontarz, J. Zapała, G. Wyszyńska-Pawelec (2018)
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              Pediatric salivary gland carcinomas: Diagnostic and therapeutic management.

              Céleste Rebours, Vincent Couloigner, Louise Galmiche … (2017)
              To analyze clinical presentations, treatment modalities, and evolution of pediatric cases of salivary gland carcinomas to standardize care for these rare diseases.
              Article 0 comments Cited 9 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Children (Basel)
                Journal ID (iso-abbrev): Children (Basel)
                Journal ID (publisher-id): children
                Title: Children
                Publisher: MDPI
                ISSN (Electronic): 2227-9067
                Publication date (Electronic): 18 September 2018
                Publication date Collection: September 2018
                Volume: 5
                Issue: 9
                Electronic Location Identifier: 127
                Affiliations
                [1 ]Department of Pharmacology, Postgraduate Institute of Medical Education and Research and Dr. Ram Manohar Lohia Hospital, New Delhi 110001, India
                [2 ]Department of Radiology, The University of Texas Health Science Centre, San Antonio, TX 78229, USA; neerajkaur99@ 123456gmail.com
                [3 ]Department of Paediatrics, Richmond University Medical Centre, Staten Island, NY 10310, USA; kanwaljeetsinghhura@ 123456gmail.com
                Author notes
                [* ]Correspondence: drgirish23@ 123456yahoo.co.in ; Tel.: +91-837-6010-560
                Author information
                https://orcid.org/0000-0003-1499-9970
                Article
                Publisher ID: children-05-00127
                DOI: 10.3390/children5090127
                PMC ID: 6162389
                PubMed ID: 30231590
                SO-VID: 94a37890-a58c-4c17-92b6-d207d5d62bc1
                Copyright © © 2018 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 18 August 2018
                Date accepted : 17 September 2018
                Categories
                Subject: Case Report

                Keywords: pleomorphic adenoma of parotid,salivary gland tumors,parotidectomy
                Data availability:
                Keywords: pleomorphic adenoma of parotid, salivary gland tumors, parotidectomy

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