The current, so-called "Millennial" generation of learners is frequently characterized as having deep understanding of, and appreciation for, technology and social connectedness. This generation of learners has also been molded by a unique set of cultural influences that are essential for medical educators to consider in all aspects of their teaching, including curriculum design, student assessment, and interactions between faculty and learners. The following tips outline an approach to facilitating learning of our current generation of medical trainees. The method is based on the available literature and the authors' experiences with Millennial Learners in medical training. The 12 tips provide detailed approaches and specific strategies for understanding and engaging Millennial Learners and enhancing their learning. With an increased understanding of the characteristics of the current generation of medical trainees, faculty will be better able to facilitate learning and optimize interactions with Millennial Learners.