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      Hydrogel Actuators and Sensors for Biomedical Soft Robots: Brief Overview with Impending Challenges

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          Abstract

          There are numerous developments taking place in the field of biorobotics, and one such recent breakthrough is the implementation of soft robots—a pathway to mimic nature’s organic parts for research purposes and in minimally invasive surgeries as a result of their shape-morphing and adaptable features. Hydrogels (biocompatible, biodegradable materials that are used in designing soft robots and sensor integration), have come into demand because of their beneficial properties, such as high water content, flexibility, and multi-faceted advantages particularly in targeted drug delivery, surgery and biorobotics. We illustrate in this review article the different types of biomedical sensors and actuators for which a hydrogel acts as an active primary material, and we elucidate their limitations and the future scope of this material in the nexus of similar biomedical avenues.

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          Most cited references291

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          Hydrogels for tissue engineering.

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            Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology

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              Hydrogels in regenerative medicine.

              Hydrogels, due to their unique biocompatibility, flexible methods of synthesis, range of constituents, and desirable physical characteristics, have been the material of choice for many applications in regenerative medicine. They can serve as scaffolds that provide structural integrity to tissue constructs, control drug and protein delivery to tissues and cultures, and serve as adhesives or barriers between tissue and material surfaces. In this work, the properties of hydrogels that are important for tissue engineering applications and the inherent material design constraints and challenges are discussed. Recent research involving several different hydrogels polymerized from a variety of synthetic and natural monomers using typical and novel synthetic methods are highlighted. Finally, special attention is given to the microfabrication techniques that are currently resulting in important advances in the field.
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                Author and article information

                Journal
                Biomimetics (Basel)
                Biomimetics (Basel)
                biomimetics
                Biomimetics
                MDPI
                2313-7673
                10 July 2018
                September 2018
                : 3
                : 3
                : 15
                Affiliations
                [1 ]Department of Biomedical Engineering, Faculty of Engineering, 4 Engineering Drive 3, National University of Singapore, Singapore 117583, Singapore; biehb@ 123456nus.edu.sg (H.B.); msuhail1997@ 123456gmail.com (M.S.)
                [2 ]Singapore Institute for Neurotechnology (SINAPSE), Centre for Life Sciences, National University of Singapore, 28 Medical Drive, #05-COR, Singapore 117456, Singapore
                [3 ]Department of Mechancial Engineering, National Institute of Technology, Tiruchirappalli, Tamil Nadu 620015, India
                [4 ]National University of Singapore (Suzhou) Research Institute (NUSRI), 377 Lin Quan Street, Suzhou Industrial Park, Suzhou 215123, China
                Author notes
                [* ]Correspondence: ren@ 123456nus.edu.sg ; Tel.: +65-6601-2802
                [†]

                These authors contributed equally to this work.

                Author information
                https://orcid.org/0000-0003-2939-646X
                https://orcid.org/0000-0002-6488-1551
                Article
                biomimetics-03-00015
                10.3390/biomimetics3030015
                6352708
                31105237
                94160c0a-0e5b-4b17-8844-874690821c76
                © 2018 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 30 April 2018
                : 25 June 2018
                Categories
                Review

                hydrogel robots,biomedical sensors,soft actuators,stimuli-responsive hydrogels

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