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      Barriers and Enablers of Healthcare Providers to Deprescribe Cardiometabolic Medication in Older Patients: A Focus Group Study

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          Abstract

          Introduction

          Benefits and risks of preventive medication change over time for ageing patients and deprescribing of medication may be needed. Deprescribing of cardiovascular and antidiabetic drugs can be challenging and is not widely implemented in daily practice.

          Objective

          The aim of this study was to identify barriers and enablers of deprescribing cardiometabolic medication as seen by healthcare providers (HCPs) of different disciplines, and to explore their views on their specific roles in the process of deprescribing.

          Methods

          Three focus groups with five general practitioners, eight pharmacists, three nurse practitioners, two geriatricians, and two elder care physicians were conducted in three cities in The Netherlands. Interviews were recorded and transcribed verbatim. Directed content analysis was performed on the basis of the Theoretical Domains Framework. Two researchers independently coded the data.

          Results

          Most HCPs agreed that deprescribing of cardiometabolic medication is relevant but that barriers include lack of evidence and expertise, negative beliefs and fears, poor communication and collaboration between HCPs, and lack of resources. Having a guideline was considered an enabler for the process of deprescribing of cardiometabolic medication. Some HCPs feared the consequences of discontinuing cardiovascular or antidiabetic medication, while others were not motivated to deprescribe when the patients experienced no problems with their medication. HCPs of all disciplines stated that adequate patient communication and involving the patients and relatives in the decision making enables deprescribing. Barriers to deprescribing included the use of medication initiated by specialists, the poor exchange of information, and the amount of time it takes to deprescribe cardiometabolic medication. The HCPs were uncertain about each other’s roles and responsibilities. A multidisciplinary approach including the pharmacist and nurse practitioner was seen as the best way to support the process of deprescribing and address barriers related to resources.

          Conclusion

          HCPs recognized the importance of deprescribing cardiometabolic medication as a medical decision that can only be made in close cooperation with the patient. To successfully accomplish the process of deprescribing they strongly recommended a multidisciplinary approach.

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          Most cited references43

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          A guide to using the Theoretical Domains Framework of behaviour change to investigate implementation problems.

          Implementing new practices requires changes in the behaviour of relevant actors, and this is facilitated by understanding of the determinants of current and desired behaviours. The Theoretical Domains Framework (TDF) was developed by a collaboration of behavioural scientists and implementation researchers who identified theories relevant to implementation and grouped constructs from these theories into domains. The collaboration aimed to provide a comprehensive, theory-informed approach to identify determinants of behaviour. The first version was published in 2005, and a subsequent version following a validation exercise was published in 2012. This guide offers practical guidance for those who wish to apply the TDF to assess implementation problems and support intervention design. It presents a brief rationale for using a theoretical approach to investigate and address implementation problems, summarises the TDF and its development, and describes how to apply the TDF to achieve implementation objectives. Examples from the implementation research literature are presented to illustrate relevant methods and practical considerations.
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            Clinical consequences of polypharmacy in elderly.

            Polypharmacy, defined as the use of multiple drugs or more than are medically necessary, is a growing concern for older adults. MEDLINE and EMBASE databases were searched from January 1, 1986 to June 30, 2013) to identify relevant articles in people aged > 65 years. We present information about: i) prevalence of polypharmacy and unnecessary medication use; ii) negative consequences of polypharmacy; and iii) interventions to improve polypharmacy. International research shows that polypharmacy is common in older adults with the highest number of drugs taken by those residing in nursing homes. Nearly 50% of older adults take one or more medications that are not medically necessary. Research has clearly established a strong relationship between polypharmacy and negative clinical consequences. Moreover, well-designed interprofessional (often including clinical pharmacist) intervention studies that focus on enrolling high-risk older patients with polypharmacy have shown that they can be effective in reducing aspects of unnecessary prescribing with mixed results on distal health outcomes.
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              Reducing inappropriate polypharmacy: the process of deprescribing.

              Inappropriate polypharmacy, especially in older people, imposes a substantial burden of adverse drug events, ill health, disability, hospitalization, and even death. The single most important predictor of inappropriate prescribing and risk of adverse drug events in older patients is the number of prescribed drugs. Deprescribing is the process of tapering or stopping drugs, aimed at minimizing polypharmacy and improving patient outcomes. Evidence of efficacy for deprescribing is emerging from randomized trials and observational studies. A deprescribing protocol is proposed comprising 5 steps: (1) ascertain all drugs the patient is currently taking and the reasons for each one; (2) consider overall risk of drug-induced harm in individual patients in determining the required intensity of deprescribing intervention; (3) assess each drug in regard to its current or future benefit potential compared with current or future harm or burden potential; (4) prioritize drugs for discontinuation that have the lowest benefit-harm ratio and lowest likelihood of adverse withdrawal reactions or disease rebound syndromes; and (5) implement a discontinuation regimen and monitor patients closely for improvement in outcomes or onset of adverse effects. Whereas patient and prescriber barriers to deprescribing exist, resources and strategies are available that facilitate deliberate yet judicious deprescribing and deserve wider application.
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                Author and article information

                Contributors
                j.abou@amsterdamumc.nl
                Journal
                Drugs Aging
                Drugs Aging
                Drugs & Aging
                Springer International Publishing (Cham )
                1170-229X
                1179-1969
                21 February 2022
                21 February 2022
                2022
                : 39
                : 3
                : 209-221
                Affiliations
                [1 ]GRID grid.16872.3a, ISNI 0000 0004 0435 165X, Department of Clinical Pharmacology and Pharmacy, , Amsterdam UMC, Location VUmc, ; Amsterdam, The Netherlands
                [2 ]GRID grid.4830.f, ISNI 0000 0004 0407 1981, Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, , University of Groningen, ; Groningen, The Netherlands
                [3 ]GRID grid.491413.a, ISNI 0000 0004 0626 420X, SIR Institute for Pharmacy Practice and Policy, ; Theda Mansholtstraat 5B, 2331 JE Leiden, The Netherlands
                [4 ]GRID grid.5477.1, ISNI 0000000120346234, Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, , Utrecht University, ; Utrecht, The Netherlands
                [5 ]GRID grid.16872.3a, ISNI 0000 0004 0435 165X, Department of Elderly Care Medicine, , Amsterdam Public Health Research Institute, ; Amsterdam UMC (location VUmc), The Netherlands
                [6 ]GRID grid.413508.b, ISNI 0000 0004 0501 9798, Geriatric Department and Center for Clinical Pharmacology, , Jeroen Bosch Hospital, ; ‘s-Hertogenbosch, The Netherlands
                [7 ]GRID grid.16872.3a, ISNI 0000 0004 0435 165X, Department of General Practice, Amsterdam UMC, location VU, , Amsterdam Public Health research institute, ; Amsterdam, The Netherlands
                [8 ]GRID grid.4830.f, ISNI 0000 0004 0407 1981, Unit of PharmacoTherapy, Epidemiology and Economics, Groningen Research Institute of Pharmacy, , University of Groningen, ; Groningen, The Netherlands
                Author information
                http://orcid.org/0000-0002-6521-6203
                Article
                918
                10.1007/s40266-021-00918-7
                8934783
                35187614
                92701fcb-82af-464c-bdcb-7dfa587869d9
                © The Author(s) 2022

                Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

                History
                : 19 December 2021
                Funding
                Funded by: knmp
                Categories
                Original Research Article
                Custom metadata
                © Springer Nature Switzerland AG 2022

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