Auffällige CT-Befunde des Schädels nach präventiver ZNS-Behandlung akuter Leukämien bei Kindern

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Abstract

Bei 15 Kindern, die im Rahmen der Leukämiebehandlung eine Sch-ädelbestrahlung und i.th. Methotrexatgaben erhielten, wurden com-putertomographische Untersuchungen des Hirnschädels angefertigt. Überraschend fanden sich bei 10 der 15 Kinder von der Norm abweichende CT-Befunde. Nur 2 der 10 »CT-positiven« Kinder wa-ren klinisch-neurologisch auffällig. Die im CT sichtbaren Verän-derungen der Hirnstruktur scheinen starker und häufiger zu sein, je länger die ZNS-Behandlung zurückliegt. Kinder bis zum 5. Lebens-jahr zeigten die schwersten Pathologika im CT und waren auch durch Krampfanfälle und Entwicklungsverzögerung aufgefallen.

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Author and article information

Journal

Journal ID (publisher-id): ONK

Journal ID (nlm-ta): Oncol Res Treat

Journal ID (doi): 10.1159/issn.2296-5270

Title: Oncology Research and Treatment

Publisher: S. Karger AG

ISSN (Print): 2296-5270

ISSN (Electronic): 2296-5262

Publication date Subscription-year: 1979

Publication date (Print): 1979

Publication date (Electronic): 17 April 2009

Volume: 2

Issue: 2

Pages: 83-86

Affiliations

Abteilung für Hämatologie der Universitäts-Kinderklinik Tübingen (Ärztlicher Direktor: Prof. Dr. D. Niethammer) und Strahleninstitut der Universität Tübingen (Direktor: Prof. Dr. Frommhold)

Article

Publisher ID: 214477 Other ID: Onkologie 1979;2:83–86

DOI: 10.1159/000214477

PubMed ID: 118413

SO-VID: 90b6c914-fbcc-4b0c-b43e-3041b4aeb7e5

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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Pages: 4

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