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      Mechanisms for doped PEDOT:PSS electrical conductivity improvement

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          Abstract

          Due to their good electrical conductivity and versatility, conductive polymers like poly(3,4-ethylene dioxythiophene) (PEDOT):poly(styrene sulphonate) (PSS), have recently attracted considerable research interest in bioelectronics applications.

          Abstract

          Due to their good electrical conductivity and versatility, conductive polymers (CPs), in particular, poly(3,4-ethylene dioxythiophene) (PEDOT):poly(styrene sulphonate) (PSS), have recently attracted considerable research interest in bioelectronics applications. This study provides insight into the mechanisms in PEDOT:PSS for increasing electrical conductivity. As such, the preparation of doped PEDOT:PSS using distinctive approaches, such as undergoing treatment and using secondary dopants is focused primarily on improving its electrical efficiency. It also systematically addresses various primary parameters that have significant effects on its conductivity. We present the potential of doped PEDOT:PSS for many promising applications in fields such as bioelectronics, through an in-depth analysis of the most remarkable studies recorded by various research groups over the past decade. Therefore, this review is expected to be significantly helpful in promoting further studies, as well as paving the way for increased qualification and productivity for future revolutions of organic CP materials.

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          Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

          Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify intraflagellar transport 20 (IFT20) as a new target of this signaling in tumors that lack primary cilia, and find that IFT20 mediates the ability of Ror2 signaling to induce the invasiveness of these tumors. We also find that IFT20 regulates the nucleation of Golgi-derived microtubules by affecting the GM130-AKAP450 complex, which promotes Golgi ribbon formation in achieving polarized secretion for cell migration and invasion. Furthermore, IFT20 promotes the efficiency of transport through the Golgi complex. These findings shed new insights into how Ror2 signaling promotes tumor invasiveness, and also advance the understanding of how Golgi structure and transport can be regulated.
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            Conductive polymers: towards a smart biomaterial for tissue engineering.

            Developing stimulus-responsive biomaterials with easy-to-tailor properties is a highly desired goal of the tissue engineering community. A novel type of electroactive biomaterial, the conductive polymer, promises to become one such material. Conductive polymers are already used in fuel cells, computer displays and microsurgical tools, and are now finding applications in the field of biomaterials. These versatile polymers can be synthesised alone, as hydrogels, combined into composites or electrospun into microfibres. They can be created to be biocompatible and biodegradable. Their physical properties can easily be optimized for a specific application through binding biologically important molecules into the polymer using one of the many available methods for their functionalization. Their conductive nature allows cells or tissue cultured upon them to be stimulated, the polymers' own physical properties to be influenced post-synthesis and the drugs bound in them released, through the application of an electrical signal. It is thus little wonder that these polymers are becoming very important materials for biosensors, neural implants, drug delivery devices and tissue engineering scaffolds. Focusing mainly on polypyrrole, polyaniline and poly(3,4-ethylenedioxythiophene), we review conductive polymers from the perspective of tissue engineering. The basic properties of conductive polymers, their chemical and electrochemical synthesis, the phenomena underlying their conductivity and the ways to tailor their properties (functionalization, composites, etc.) are discussed.
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              On the mechanism of conductivity enhancement in poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) film through solvent treatment

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                Author and article information

                Contributors
                (View ORCID Profile)
                Journal
                MAADC9
                Materials Advances
                Mater. Adv.
                Royal Society of Chemistry (RSC)
                2633-5409
                November 15 2021
                2021
                : 2
                : 22
                : 7118-7138
                Affiliations
                [1 ]Department of Manufacturing and Materials Engineering, Kulliyyah of Engineering, International Islamic University Malaysia, 53100 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
                [2 ]Department of Electrical and Computer Engineering, Kulliyyah of Engineering, International Islamic University Malaysia, 53100 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
                [3 ]Department of Mechanical Engineering, Faculty of Industrial Technology, Universitas Pertamina, 12220 Jakarta, Indonesia
                Article
                10.1039/D1MA00290B
                90196dbb-7ecb-436d-9ba1-c5177a8d8852
                © 2021

                http://creativecommons.org/licenses/by-nc/3.0/

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