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      Gastrointestinal tolerability of organic infant formula compared to traditional ‎infant formula: A systematic review

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          Abstract

          BACKGROUND

          Infants' nutrition significantly influences their growth, development, and overall well-being. With the increasing demand for organic infant formula driven by the perception of health benefits and growing awareness of natural feeding options, it is crucial to conduct a comparative analysis of the gastrointestinal tolerability between organic and traditional infant formulas.

          AIM

          To provide a concise and precise analysis of the gastrointestinal tolerability of organic infant formula compared to traditional infant formula. Due to limited direct comparisons, the review synthesizes available literature on each formula type, presenting insights into their potential effects on infants' digestive health.

          METHODS

          An extensive literature search was conducted, compiling studies on organic and traditional infant formulas, their compositions, and reported effects on gastrointestinal tolerability. We searched academic databases such as PubMed and Google Scholar and specialized ‎nutrition, paediatrics, and infant health journals using relevant keywords till October 1, 2023. ‎

          RESULTS

          Although specific comparative studies are scarce and formula heterogeneity is a significant limitation, this systematic review provides an in-depth understanding of organic infant formulas' composition and potential benefits. While scientific evidence directly comparing gastrointestinal tolerability is limited, organic formulas strive to use carefully selected organic ingredients to imitate breast milk composition. Potential benefits include improved lipid profiles, higher methionine content, and decreased antibiotic-resistant bacteria levels. Understanding the gastrointestinal tolerability of organic and traditional infant formulas is crucial for parents and healthcare providers to make informed decisions.

          CONCLUSION

          Despite limitations in direct comparisons, this systematic review provides insights into the composition and potential benefits of organic infant formulas. It emphasizes the need for further research to elucidate their gastrointestinal effects comprehensively.

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          Most cited references74

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          Maternal and child undernutrition: global and regional exposures and health consequences.

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            Review of Infant Feeding: Key Features of Breast Milk and Infant Formula

            Mothers’ own milk is the best source of nutrition for nearly all infants. Beyond somatic growth, breast milk as a biologic fluid has a variety of other benefits, including modulation of postnatal intestinal function, immune ontogeny, and brain development. Although breastfeeding is highly recommended, breastfeeding may not always be possible, suitable or solely adequate. Infant formula is an industrially produced substitute for infant consumption. Infant formula attempts to mimic the nutritional composition of breast milk as closely as possible, and is based on cow’s milk or soymilk. A number of alternatives to cow’s milk-based formula also exist. In this article, we review the nutritional information of breast milk and infant formulas for better understanding of the importance of breastfeeding and the uses of infant formula from birth to 12 months of age when a substitute form of nutrition is required.
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              Breast- v. formula-feeding: impacts on the digestive tract and immediate and long-term health effects.

              The health benefits of breast-feeding have been recognised for a long time. In particular, breast-feeding is associated with lower incidence of necrotising enterocolitis and diarrhoea during the early period of life and with lower incidence of inflammatory bowel diseases, type 2 diabetes and obesity later in life. The higher nutritional and protective degree of human milk is related to its nutritional composition that changes over the lactation period and to the biological activities of specific components while lower growth rate of breast-fed infants may be attributed to their self-regulation of milk intake at a lower level than formula-fed infants. Many results now suggest that the developmental changes in intestinal and pancreatic function that occur postnatally are modulated by the diet. Indeed, formula-feeding induces intestinal hypertrophy and accelerates maturation of hydrolysis capacities; it increases intestinal permeability and bacterial translocation, but does not induce evident differences in microbiota composition. Whether these changes would be beneficial for enhancing absorptive capacities and for educating the gut-associated immune system remains to be further studied. Moreover, it is evident that formula-feeding increases basal blood glucose and decreases plasma ketone body concentrations, while discrepancies on postprandial glycaemia, insulin and incretin responses in both human studies and experimental studies are inconclusive. Manipulating the composition of formula, by reducing protein content, adding prebiotics, growth factors or secretory IgA can modulate intestinal and pancreatic function development, and thereby may reduce the differential responses between breast-fed and formula-fed neonates. However, the developmental responses of the digestive tract to different feeding strategies must be elucidated in terms of sensitivity to developing diseases, taking into account the major role of the intestinal microbiota.
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                Author and article information

                Contributors
                Journal
                World J Clin Pediatr
                WJCP
                World Journal of Clinical Pediatrics
                Baishideng Publishing Group Inc
                2219-2808
                9 March 2024
                9 March 2024
                : 13
                : 1
                : 88783
                Affiliations
                Department of Pediatric, Faculty of Medicine, Tanta University, Tanta 31511, Alghrabia, Egypt
                Department of Pediatric, University Medical Center, King Abdulla Medical City, Arabian Gulf University, Dr. Sulaiman Al Habib ‎Medical ‎‎Group, Manama 26671, Manama, Bahrain. mbelrem@ 123456hotmail.com
                Medical Microbiology Section, Department of Pathology, Salmaniya Medical Complex, ‎Ministry of Health, Kingdom of Bahrain, Manama 12, Manama, Bahrain
                Medical Microbiology Section, Department of Pathology, Irish Royal College of Surgeon, Busaiteen 15503‎, Muharraq, Bahrain
                Department of Pulmonology, Faculty of Medicine, Tanta University, Tanta ‎‎ 31527, Alghrabia, Egypt
                Department of Pulmonology, University Medical Center, King Abdulla Medical City, ‎‎Arabian Gulf University, Dr. ‎Sulaiman Al Habib Medical Group, Manama‎ 26671, Manama, Bahrain
                Department of Medicine, The Royal College of Surgeons in Ireland - Bahrain, ‎Busiateen 15503, Muharraq, Bahrain
                Department of Pediatric, Faculty of Medicine, Tanta ‎University, Tanta ‎ 31511‎, Algahrbia, Egypt
                Author notes

                Author contributions: Al-Biltagi M developed the idea, collected data, and wrote and revised the manuscript; Saeed NK collected the data and revised the manuscript from the laboratory aspect; Elbeltagi R collected the data, wrote the method section and revised the manuscript; Bediwy AS collected the data and revised the manuscript; Hamza MB collected the data and revised the manuscript.

                Corresponding author: Mohammed Al-Beltagi, MBChB, MD, PhD, Academic Editor, Chairman, Professor, Research Scientist, Department of Pediatrics, Faculty of Medicine, Tanta University, Al-Bahr Street, The Medical Complex, Tanta ‎31511‎, Alghrabia, Egypt. mbelrem@ 123456hotmail.com

                Article
                jWJCP.v13.i1.eid88783 88783
                10.5409/wjcp.v13.i1.88783
                11000068
                38596433
                8ec016ad-b221-41a4-9e81-769ee7e1d1ea
                ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

                This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

                History
                : 9 October 2023
                : 13 December 2023
                : 4 January 2024
                Categories
                Systematic Reviews

                organic infant formula,traditional infant formula,gastrointestinal tolerability,‎formula ingredients,digestive health,infant nutrition,organic farming

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