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Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
January 01 2000
January 01 2000
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Abstract
<p class="first" id="d7902004e57">The pathophysiological characteristics of schizophrenia
appear to involve altered
synaptic connectivity in the dorsolateral prefrontal cortex. Given the central role
that layer 3 pyramidal neurons play in corticocortical and thalamocortical connectivity,
we hypothesized that the excitatory inputs to these neurons are altered in subjects
with schizophrenia.
</p>