A single‐question screen for rapid eye movement sleep behavior disorder: A multicenter validation study

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Background:

Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia that is an important risk factor for Parkinson's disease (PD) and Lewy body dementia. Its prevalence is unknown. One barrier to determining prevalence is that current screening tools are too long for large‐scale epidemiologic surveys. Therefore, we designed the REM Sleep Behavior Disorder Single‐Question Screen (RBD1Q), a screening question for dream enactment with a simple yes/no response.

Methods:

Four hundred and eighty‐four sleep‐clinic–based participants (242 idiopathic RBD patients and 242 controls) completed the screen during a multicenter case‐control study. All participants underwent a polysomnogram to define gold‐standard diagnosis according to standard criteria.

Results:

We found a sensitivity of 93.8% and a specificity of 87.2%. Sensitivity and specificity were similar in healthy volunteers, compared to controls or patients with other sleep diagnoses.

Conclusions:

Related collections

Most cited references 16

Record: found
Abstract: not found
Article: not found

“Mini-mental state”

Marshal Folstein, Susan Folstein, Paul McHugh (1975)

0 comments Cited 2580 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Article: not found

Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.

A J Hughes, S Daniel, L Kilford … (1992)

0 comments Cited 613 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

The REM sleep behavior disorder screening questionnaire--a new diagnostic instrument.

Karin Stiasny-Kolster, Geert Mayer, Sylvia Schäfer … (2007)

Many patients with assumed idiopathic REM sleep behavior disorder (RBD) may actually represent an early clinical manifestation of an evolving neurodegenerative disorder, such as the alpha-synucleinopathies, Parkinson's disease or multiple system atrophy. Early detection of these patients is clinically relevant for long-term prospective as well as future neuroprotective studies. For this purpose, we validated a 10-item patient self-rating questionnaire (maximum total score 13 points) covering the clinical features of RBD. The RBD screening questionnaire (RBDSQ) was applied to 54 patients with polysomnographically confirmed RBD (29 men; mean age 53.7 +/- 15.8 years), 160 control subjects (81 men; mean age 50.8 +/- 15.5 years) in whom RBD was excluded by history and polysomnography (PSG, control group 1) and 133 unselected healthy subjects (58 men; mean age 46.9 +/- 12.3 years; no PSG, control group 2). In most subjects (n = 153) of control group 1, other sleep-wake disturbances were present. The mean RBDSQ score in the RBD group was 9.5 +/- 2.8 points compared with 4.6 +/- 3.0 points in control group 1 (P < 0.0001). Considering an RBDSQ score of five points as a positive test result, we found a sensitivity of 0.96 and a specificity of 0.56. The RBDSQ poorly discriminated patients with the most challenging differential diagnoses such as sleepwalking or epilepsy. In control group 2, the mean RBDSQ score (2.02 +/- 1.78) was significantly lower than in the RBD group (P < 0.0005), revealing a specificity of 0.92. Due to its high sensitivity, the RBDSQ appears to be particularly useful as a screening tool. 2007 Movement Disorder Society