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A case of subependymal giant cell astrocytoma without tuberous sclerosis complex and review of the literature.
Michael O'Rawe
1 ,
Arjun S Chandran
2
,
3 ,
Stuti Joshi
4 ,
Alexandre Simonin
1 ,
Jason M Dyke
5 ,
Sharon Lee
1
,
6
Apr 2021
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Abstract
Subependymal giant cell astrocytoma (SEGA) is a World Health Organization (WHO) grade I tumor most commonly seen in the context of the underlying tuberous sclerosis complex (TSC). SEGA in the absence of TSC is exceedingly rare. We report the youngest known case of SEGA in the absence of genetic or phenotypic evidence of TSC with a 10-year follow-up. We discuss the literature surrounding isolated SEGA including an approach to diagnosis, management, and prognosis.