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      A comprehensive review of Cornus officinalis: health benefits, phytochemistry, and pharmacological effects for functional drug and food development

      systematic-review

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          Abstract

          Introduction

          Cornus officinalis sieb. et zucc, a deciduous tree or shrub, is renowned for its “Cornus flesh” fruit, which is widely acknowledged for its medicinal value when matured and dried. Leveraging C. officinalis as a foundational ingredient opens avenues for the development of environmentally friendly health foods, ranging from beverages and jams to preserves and canned products. Packed with diverse bioactive compounds, this species manifests a spectrum of pharmacological effects, including anti-inflammatory, antioxidant, antidiabetic, immunomodulatory, neuroprotective, and cardiovascular protective properties.

          Methods

          This study employs CiteSpace visual analysis software and a bibliometric analysis platform, drawing upon the Web of Science (WOS) database for literature spanning the last decade. Through a comprehensive analysis of available literature from WOS and Google Scholar, we present a thorough summary of the health benefits, phytochemistry, active compounds, and pharmacological effects of C. officinalis. Particular emphasis is placed on its potential in developing functional drugs and foods.

          Results and Discussion

          While this review enhances our understanding of C. officinalis as a prospective therapeutic agent, its clinical applicability underscores the need for further research and clinical studies to validate findings and establish safe and effective clinical applications.

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          Most cited references147

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          Polyphenols: food sources and bioavailability.

          Polyphenols are abundant micronutrients in our diet, and evidence for their role in the prevention of degenerative diseases such as cancer and cardiovascular diseases is emerging. The health effects of polyphenols depend on the amount consumed and on their bioavailability. In this article, the nature and contents of the various polyphenols present in food sources and the influence of agricultural practices and industrial processes are reviewed. Estimates of dietary intakes are given for each class of polyphenols. The bioavailability of polyphenols is also reviewed, with particular focus on intestinal absorption and the influence of chemical structure (eg, glycosylation, esterification, and polymerization), food matrix, and excretion back into the intestinal lumen. Information on the role of microflora in the catabolism of polyphenols and the production of some active metabolites is presented. Mechanisms of intestinal and hepatic conjugation (methylation, glucuronidation, sulfation), plasma transport, and elimination in bile and urine are also described. Pharmacokinetic data for the various polyphenols are compared. Studies on the identification of circulating metabolites, cellular uptake, intracellular metabolism with possible deconjugation, biological properties of the conjugated metabolites, and specific accumulation in some target tissues are discussed. Finally, bioavailability appears to differ greatly between the various polyphenols, and the most abundant polyphenols in our diet are not necessarily those that have the best bioavailability profile. A thorough knowledge of the bioavailability of the hundreds of dietary polyphenols will help us to identify those that are most likely to exert protective health effects.
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            Chemical studies of anthocyanins: A review

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              Science Mapping: A Systematic Review of the Literature

              We present a systematic review of the literature concerning major aspects of science mapping to serve two primary purposes: First, to demonstrate the use of a science mapping approach to perform the review so that researchers may apply the procedure to the review of a scientific domain of their own interest, and second, to identify major areas of research activities concerning science mapping, intellectual milestones in the development of key specialties, evolutionary stages of major specialties involved, and the dynamics of transitions from one specialty to another. We first introduce a theoretical framework of the evolution of a scientific specialty. Then we demonstrate a generic search strategy that can be used to construct a representative dataset of bibliographic records of a domain of research. Next, progressively synthesized co-citation networks are constructed and visualized to aid visual analytic studies of the domain’s structural and dynamic patterns and trends. Finally, trajectories of citations made by particular types of authors and articles are presented to illustrate the predictive potential of the analytic approach. The evolution of the science mapping research involves the development of a number of interrelated specialties. Four major specialties are discussed in detail in terms of four evolutionary stages: conceptualization, tool construction, application, and codification. Underlying connections between major specialties are also explored. The predictive analysis demonstrates citations trajectories of potentially transformative contributions. The systematic review is primarily guided by citation patterns in the dataset retrieved from the literature. The scope of the data is limited by the source of the retrieval, i.e. the Web of Science, and the composite query used. An iterative query refinement is possible if one would like to improve the data quality, although the current approach serves our purpose adequately. More in-depth analyses of each specialty would be more revealing by incorporating additional methods such as citation context analysis and studies of other aspects of scholarly publications. The underlying analytic process of science mapping serves many practical needs, notably bibliometric mapping, knowledge domain visualization, and visualization of scientific literature. In order to master such a complex process of science mapping, researchers often need to develop a diverse set of skills and knowledge that may span multiple disciplines. The approach demonstrated in this article provides a generic method for conducting a systematic review. Incorporating the evolutionary stages of a specialty into the visual analytic study of a research domain is innovative. It provides a systematic methodology for researchers to achieve a good understanding of how scientific fields evolve, to recognize potentially insightful patterns from visually encoded signs, and to synthesize various information so as to capture the state of the art of the domain.
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                Author and article information

                Contributors
                Role: Role:
                Role: Role:
                URI : https://loop.frontiersin.org/people/2136460/overviewRole: Role:
                Role:
                URI : https://loop.frontiersin.org/people/1817180/overviewRole: Role:
                URI : https://loop.frontiersin.org/people/2178508/overviewRole: Role:
                URI : https://loop.frontiersin.org/people/1110810/overviewRole: Role: Role:
                Journal
                Front Nutr
                Front Nutr
                Front. Nutr.
                Frontiers in Nutrition
                Frontiers Media S.A.
                2296-861X
                11 January 2024
                2023
                : 10
                : 1309963
                Affiliations
                [1] 1College of Physical Education, Shaanxi University of Technology , Hanzhong, China
                [2] 2Shaanxi Province Key Laboratory of Bioresources, QinLing-Bashan Mountains Bioresources Comprehensive Development C. I. C., Qinba State Key Laboratory of Biological Resources and Ecological Environment, College of Bioscience and Bioengineering, Shaanxi University of Technology , Hanzhong, Shaanxi, China
                [3] 3College of Health Management, Shangluo University , Shangluo, Shaanxi, China
                [4] 4ShaanxiUnion Research Center of University and Enterprise for Health Food Ingredient and Walnut Industry , Shangluo, Shaanxi, China
                [5] 5Pak-Austria Fachhochschule lnstitute of Applied Sciences and Technology , Haripur, Pakistan
                [6] 6Department of Chemical Technology,Faculty of Science, Chulalongkorn University , Bangkok, Thailand
                [7] 7Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University , Giza, Egypt
                [8] 8Department of Medical Pharmacology, Faculty of Medicine, Atatürk University , Erzurum, Türkiye
                Author notes

                Edited by: Ding-Tao Wu, Chengdu University, China

                Reviewed by: Hong-Yan Liu, Chinese Academy of Agricultural Sciences, China; Hui Teng, Guangdong Ocean University, China

                *Correspondence: Wenhui Deng, dengwh55555@ 123456163.com

                These authors share first authorship

                Article
                10.3389/fnut.2023.1309963
                10809406
                38274211
                89827196-0020-4273-b8f6-9bf4ad3a3aa9
                Copyright © 2024 Deng, Liu, Guo, Chen, Abdu, Khan, Palanisamy, Pei and Abd El-Aty.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 24 October 2023
                : 04 December 2023
                Page count
                Figures: 8, Tables: 4, Equations: 0, References: 148, Pages: 16, Words: 12071
                Funding
                The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was funded by the Key Basic Research Project of Shaanxi Provincial Department of Science and Technology (2023-JC-ZD-13), the Special Support Plan for High-Level Talents in Shaanxi Province (for JP), the Foreign Expert Project of the Ministry of Science and Technology, and the Project for Scientific and Technological Innovation Team in Shangluo City of Shaanxi Province (SK2019-72).
                Categories
                Nutrition
                Systematic Review
                Custom metadata
                Nutrition and Food Science Technology

                cornus officinalis,health characteristics,biological activity,pharmacological effects,cornaceae

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