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      Analysis and identification of phenolic compounds with antiproliferative activity from Chinese olive ( Canarium album L.) fruit extract by HPLC-DAD-SPE-TT-NMR

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          Abstract

          Chinese olives ( Canarium album L.) are rich in phenolic compounds, exhibiting a broad spectrum of potential clinical applications. This study is the first report on the isolation and elucidation of bioactive compounds with high antiproliferative activity from the ethyl acetate fraction of a Chinese olive fruit methanolic extract (CO-EtOAc). We used the WST-1 assay to determine which subfractions of CO-EtOAc had significant antiproliferative activity using the murine colon cancer cell line CT26. Subsequently, the functional compounds were characterized by the hyphenated technique and high-performance liquid chromatography-diode array detector-solid phase extraction-transfer tube-nuclear magnetic resonance (HPLC-DAD-SPE-TT-NMR). Thirteen phenolic constituents were identified from the antiproliferation-enhancing subfractions of CO-EtOAc, including two new compounds, 2,4-didehydrochebulic acid 1,7-dimethyl ester (5) and 1-hydroxybrevifolin (7), which were further purified and found to exhibit marked antiproliferative activity. Chebulic acid dimethyl ester (2), which was isolated from C. album for the first time, also possessed antiproliferative activity.

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          Colorectal cancer statistics, 2020

          Rebecca Siegel, Kimberly D Miller, Ann Goding Sauer … (2020)
          Colorectal cancer (CRC) is the second most common cause of cancer death in the United States. Every 3 years, the American Cancer Society provides an update of CRC occurrence based on incidence data (available through 2016) from population-based cancer registries and mortality data (through 2017) from the National Center for Health Statistics. In 2020, approximately 147,950 individuals will be diagnosed with CRC and 53,200 will die from the disease, including 17,930 cases and 3,640 deaths in individuals aged younger than 50 years. The incidence rate during 2012 through 2016 ranged from 30 (per 100,000 persons) in Asian/Pacific Islanders to 45.7 in blacks and 89 in Alaska Natives. Rapid declines in incidence among screening-aged individuals during the 2000s continued during 2011 through 2016 in those aged 65 years and older (by 3.3% annually) but reversed in those aged 50 to 64 years, among whom rates increased by 1% annually. Among individuals aged younger than 50 years, the incidence rate increased by approximately 2% annually for tumors in the proximal and distal colon, as well as the rectum, driven by trends in non-Hispanic whites. CRC death rates during 2008 through 2017 declined by 3% annually in individuals aged 65 years and older and by 0.6% annually in individuals aged 50 to 64 years while increasing by 1.3% annually in those aged younger than 50 years. Mortality declines among individuals aged 50 years and older were steepest among blacks, who also had the only decreasing trend among those aged younger than 50 years, and excluded American Indians/Alaska Natives, among whom rates remained stable. Progress against CRC can be accelerated by increasing access to guideline-recommended screening and high-quality treatment, particularly among Alaska Natives, and elucidating causes for rising incidence in young and middle-aged adults.
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            Global patterns and trends in colorectal cancer incidence and mortality.

            Melina Arnold, Mónica S Sierra, Mathieu Laversanne … (2016)
            The global burden of colorectal cancer (CRC) is expected to increase by 60% to more than 2.2 million new cases and 1.1 million deaths by 2030. In this study, we aim to describe the recent CRC incidence and mortality patterns and trends linking the findings to the prospects of reducing the burden through cancer prevention and care.
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              Polyphenols contents and antioxidant capacity of 68 Chinese herbals suitable for medical or food uses

              Haiying Liu, Nongxue Qiu, Huihuang Ding … (2008)
              Article 0 comments Cited 61 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Yu-Te Yeh: Role: MethodologyRole: Formal analysisRole: InvestigationRole: ResourcesRole: Writing – original draftRole: Visualization
                Chien-Kuang Chen: Role: ConceptualizationRole: SoftwareRole: Formal analysisRole: InvestigationRole: Writing – original draftRole: Writing – review & editingRole: Visualization
                Yi-Chun Liao: Role: ValidationRole: InvestigationRole: Data curationRole: Writing – original draftRole: Writing – review & editingRole: Funding acquisition
                Shoei-Sheng Lee: Role: ConceptualizationRole: SoftwareRole: InvestigationRole: Supervision
                Shu-Chen Hsieh: Role: ValidationRole: Data curationRole: Writing – original draftRole: Writing – review & editingRole: SupervisionRole: Project administrationRole: Funding acquisition
                Journal
                Journal ID (nlm-ta): J Food Drug Anal
                Journal ID (iso-abbrev): J Food Drug Anal
                Title: Journal of Food and Drug Analysis
                Publisher: Taiwan Food and Drug Administration
                ISSN (Print): 1021-9498
                ISSN (Electronic): 2224-6614
                Publication date (Electronic, collection): 2023
                Publication date (Electronic, pub): 15 December 2023
                Volume: 31
                Issue: 4
                Pages: 639-648
                Affiliations
                [a ]Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan
                [b ]Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
                [c ]School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan
                [d ]Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan
                Author notes
                [* ]Corresponding author at: Institute of Food Science and Technology National Taiwan University NO. 1, Section 4, Roosevelt Road., Taipei 10617, Taiwan, ROC. E-mail address: schsieh@ 123456ntu.edu.tw (S.-C. Hsieh).
                [1]

                These authors contributed equally to this work.

                Article
                Publisher ID: jfda-31-04-639
                DOI: 10.38212/2224-6614.3481
                PMC ID: 10962664
                PubMed ID: 38526815
                SO-VID: 88635a01-a0c8-41f1-b6d6-8cf192be8992
                Copyright © © 2023 Taiwan Food and Drug Administration
                License:

                This is an open access article under the CC-BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 16 July 2023
                Date accepted : 11 October 2023
                Funding
                Funded by: National Science and Technology Council, Taiwan
                Award ID: MOST 104-2320-B-002-039
                Award ID: MOST 110-2811-B-002-268
                Award ID: MOST 108-2320-B-002-068
                This research was funded by the National Science and Technology Council, Taiwan (MOST 104-2320-B-002-039, MOST 110-2811-B-002-268, and MOST 108-2320-B-002-068).
                Categories
                Subject: Original Article

                Keywords: antiproliferation,chebulic acid 1,7-dimethyl ester,chinese olive (canarium album l.),hplc-dad-spe-ttnmr,1-hydroxybrevifolin,2,4-didehydrochebulic acid 1
                Data availability:
                Keywords: antiproliferation, chebulic acid 1, 7-dimethyl ester, chinese olive (canarium album l.), hplc-dad-spe-ttnmr, 1-hydroxybrevifolin, 2, 4-didehydrochebulic acid 1

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