Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis.

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Abstract

In sepsis, prolonged, sympathetic overstimulation may lead to vasopressor-refractory hypotension. We therefore examined the effects of the α2-adrenergic agonist clonidine on mean arterial pressure, renal sympathetic nerve activity, and pressor responsiveness to phenylephrine and angiotensin II during hypotensive sepsis in conscious sheep.

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Journal

Journal ID (iso-abbrev): Crit Care Med

Title: Critical care medicine

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1530-0293

ISSN (Print): 0090-3493

Publication date (Electronic): Jul 2015

Volume: 43

Issue: 7

Affiliations

[1 ] 1Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia. 2Department of Physiology, Monash University, VIC, Australia. 3Department of Physiology, University of Lyon, Lyon, France. 4Department of Intensive Care, Austin Health, Heidelberg, VIC, Australia. 5Department of Medicine, Austin Health, Heidelberg, VIC, Australia. 6The Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.

Article

DOI: 10.1097/CCM.0000000000000963

PubMed ID: 25860204

SO-VID: 881b66be-b637-49a6-8c2a-1c93b2fee1e6

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